Abstract: Disclosed herein are compositions and methods for using modified liposomes comprising (i) an encapsulated hydrophilic acridinium ester (AE), and (ii) a first agent encapsulated by the liposomes and/or (iii) a second agent on the surface of the liposomes. Specifically, the disclosed methods provide methods of labeling a target of interest, assaying a biological sample for a target antigen, and detecting a target antigen in a biological sample. Further disclosed herein are methods for increasing the strength of a signal detected by an imaging modality.

Abstract: Disclosed herein are methods for using modified liposomes or carrier proteins comprising (i) an acridinium ester (AE), and (ii) a first agent encapsulated by the liposomes and/or (iii) a second agent on the surface of the liposomes or the carrier proteins. Specifically, the disclosed methods provide methods of labeling a target of interest, assaying a biological sample for a target antigen, and detecting a target antigen in a biological sample. Further disclosed herein are methods for increasing the strength of a signal detected by an imaging modality.

Abstract: Disclosed herein are compositions and methods for removing interfering substances from biological samples, biochemical assays, or reagents used in biological samples using porous liposomes that capture and in some instances enrich said interfering substances within the liposomes.

Abstract: The present disclosure provides dry powder antibiotic compositions that are effective in the treatment of bacterial infections and associated conditions. Moreover, the present disclosure provides dry powder antibiotic compositions for the treatment of bacterial infections, by multi-drug resistant bacteria, resulting in the subsequent reduction in the prevalent rates of drug resistance.

Abstract: The present disclosure provides dry powder antibiotic compositions that are effective in the treatment of bacterial infections and associated conditions. Moreover, the present disclosure provides dry powder antibiotic compositions for the treatment of bacterial infections, by multi-drug resistant bacteria, resulting in the subsequent reduction in the prevalent rates of drug resistance.

Abstract: The present disclosure provides dry powder antibiotic compositions that are effective in the treatment of bacterial infections and associated conditions. Moreover, the present disclosure provides dry powder antibiotic compositions for the treatment of bacterial infections, by multi-drug resistant bacteria, resulting in the subsequent reduction in the prevalent rates of drug resistance.

Abstract: A dry powder formulation comprising a combination of at least a first pharmaceutically active quinolone and a second pharmaceutically active quinolone.

Abstract: The present invention relates to a glass breaking cap for a flashlight or baton, which has a bottom portion corresponding in configuration to and connectable with an end of the flashlight or baton, a top portion tapering upward such that the cap has a cross section whose two adjacent upper sides form a first included angle greater than 140 degrees, and a striking portion extending upward from a central area of the top portion. The striking portion is conical and has a cross section whose two adjacent upper sides form a second included angle less than 100 degrees. Thus, when the cap is connected to the end of the flashlight or baton and struck against a glass barrier, the striking portion creates a breaking point on the glass barrier, thus allowing the top portion to further crush the internal cohesion of the glass barrier and thereby break the glass barrier.

Abstract: An asset securing and tracking system (30) operates in conjunction with a wireless communication network (65) for tracking a portable asset (35). The system (30) includes a tracking device (31) adapted to be attached to the portable asset (35) and communicate with the wireless communication network (65). The tracking device (31) determines the location of the asset (35) using signals from GPS satellites (55) and the terrestrial wireless communication network (65). A monitoring station (32) receives and processes a location signal regarding the geographic location of the portable asset (35) from tracking device (31) via the wireless communication network (65).

Abstract: A damascene structure for semiconductor devices is provided. In an embodiment, the damascene structure includes trenches formed over vias that electrically couple the trenches to an underlying conductive layer such that the trenches have varying widths. The vias are lined with a first barrier layer. The first barrier layers along the bottom of vias are removed such that a recess formed in the underlying conductive layer. The recesses formed along the bottom of vias are such that the recess below narrower trenches is greater than the recess formed below wider trenches. In another embodiment, a second barrier layer may then be formed over the first barrier layer. In this embodiment, a portion of the conductive layer may be interposed between the first barrier layer and the second barrier layer.

Abstract: A new method is provided for monitoring silicon quality, the new method is applied at the time of pre-salicidation of the silicon substrate. The optical refractive index of the pre-salicide substrate is monitored, this monitoring provides insight into the quality of the silicon substrate at that time of a substrate processing cycle.

Abstract: This invention provides a design for the uninterruptible power supply system to make it more compact in size, more intelligent in handling primary power source and other power source failure, more efficient and reliable. This 600 to 1000 watt power system is capable of taking AC, DC and battery power inputs and distributes to multiple loads after conversion. Its power sentry monitors and controls all power inputs and outputs, and capable of switching power inputs without affecting the outputs in case of power source failure. The power sentry also controls the speeds of the cooling fans, charges the batteries, communicates with the operator, displays status, manages power consumption, prepares the substitute power source before switching power source, and shuts down the whole system incase of emergencies.

Abstract: This invention relates to a D-amino acid oxidase of the genus Rhodosporidium and a gene encoding it.

Abstract: A method of screening for a given enzyme in colony-forming cells using a substrate of the enzyme that has low solubility. Use of such a method leads to the discovery of glutaryl-7-aminocephalosporanic acid (GL-7-ACA) acylase of Pseudomonas nitroreducens. Also disclosed is a method of obtaining GL-7-ACA acylase from Pseudomonas cells.

Abstract: A method of converting cephalosporin C to glutaryl-7-aminocephalosporanic acid. The method including obtaining a cell preparation from a microorganism which produces D-amino acid oxidase, the preparation being a cell-free extract or a suspension of permeated cells; adding a D-.alpha.-amino acid to the preparation; after the adding step, heating the preparation at 50.degree.-75.degree. C. for 5-60 minutes; and incubating cephalosporin C in the preparation. Also disclosed are a method of converting cephalosporin C to glutaryl-7-aminocephalosporanic acid in the absence of exogenous H.sub.2 O.sub.2, and a method of screening for a D-amino acid oxidase-producing microorganism.