Patents by Inventor Hugh D. Burns

Hugh D. Burns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Radiolabeled farnesyl-protein transferase inhibitors
    Patent number: 6060038
    Abstract: The present invention is directed toward radiolabeled farnesyl-protein transferase inhibitor compounds which are useful to label FPTase in assays, whether cell-based, tissue-based or in whole animal. The tracers can also be used in competitive binding assays to obtain information on the interaction of unlabeled FTIs with FPTase.
    Type: Grant
    Filed: May 7, 1998
    Date of Patent: May 9, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Hugh D. Burns, Wai-Si Eng, Raymond E. Gibson
  • Thiolactone bifunctional chelating agents for diagnostic and therapeutic products
    Patent number: 5196515
    Abstract: A bifunctional ligand to compositions produced by reaction of the ligand with compounds containing an amino, thiolate or alcholate group, especially proteins, to chelates produced by complexing ligands with metal such as technetium and rhenium and to diagnostic and therapeutic uses of the complexes.
    Type: Grant
    Filed: September 6, 1991
    Date of Patent: March 23, 1993
    Assignee: The Johns Hopkins University
    Inventors: Susan Z. Lever, Kwamena E. Baidoo, Alfred V. Kramer, Hugh D. Burns
  • Thiolactone bifunctional chelating agents for diagnostic and therapeutic products
    Patent number: 5095111
    Abstract: A bifunctional ligand to compositions produced by reaction of those ligand with compounds containing an amino, thiolate or alcholate group, especially proteins, to chelates produced by complexing ligand with metals such as technetium and rhenium and to diagnostic and therapeutic uses of said complexes.
    Type: Grant
    Filed: March 17, 1989
    Date of Patent: March 10, 1992
    Assignee: The John Hopkins University
    Inventors: Susan Z. Lever, Kwamena E. Baidoo, Alfred V. Kramer, Hugh D. Burns
  • Selective acetylcholinesterase inhibitors and methods of making and using same
    Patent number: 5082964
    Abstract: A new group of alpha substituted cresol choline carbonate salts, that act as site-specific, irreversible inhibitors of acetylcholinesterase. A halomethylation method and a halogenation method for producing said alpha substituted cresol choline carbonate salts and analogs thereof. Methods of using the inhibitors as anticholinergic insecticides and to reduce acetylcholinesterase activity levels in organisms with excessive levels of acetylcholinesterase.
    Type: Grant
    Filed: June 10, 1986
    Date of Patent: January 21, 1992
    Assignee: Lehigh University
    Inventors: Ned D. Heindel, Miguel Turizo, Hugh D. Burns, Venkataraman Balasubramanian
  • Brain imaging radiopharmaceuticals
    Patent number: 4638051
    Abstract: The present invention relates to coordination compounds of technetium-99m and chelating agents (ligands) for synthesizing them. The technetium compounds are useful as diagnostic brain imaging radiopharmaceuticals.
    Type: Grant
    Filed: April 17, 1985
    Date of Patent: January 20, 1987
    Assignee: The Johns Hopkins University
    Inventors: Hugh D. Burns, Susan E. Zemyan, Leon A. Epps, Alfred V. Kramer, Robert F. Dannals