Abstract: A new and improved method and apparatus for determining cerebral oxygenation. In one basic aspect, a new processing methodology for oxygenation determination, in particular cerebral oxygenation, is provided based on the apprehension and discovery that time-based photon quantity determinations of the wavelength-specific light leaving the head of the patient may be significantly improved, and simplified, by determining the quantity of returning photons in at least one set of two different but closely spaced points in time following the instant of injection, and then taking the ratio of the determinations in each set, to thereby cancel and remove several important sources of error.

Abstract: An brain scanning apparatus having a scanner device and a host computer. The scanner radiation detectors detect radiation emitted from a desired portion, or slice, of a brain source. The scanner device contains microprocessors and code which control the movement of the radiation detectors and performs the data acquisition over a number of slices and transmits this data to the host computer. The host computer initiates a scan by sending desired setup parameters to the scanner device and instructing the scanner to begin collecting data. During the scan, acquired data is sent to the host computer and spooled to a hard disk. The computer can be instructed to perform a slice by slice reconstruction of the source brain while the scan is taking place in order to produce a 2-dimensional reconstruction of the mapped brain. A complete 3-dimensional reconstruction of all the compiled slices is performed and visually displayed after acquisition of all the required slices.

Abstract: An brain scanning apparatus having a scanner device and a host computer. The scanner radiation detectors detect radiation emitted from a desired portion, or slice, of a brain source. The scanner device contains microprocessors and code which control the movement of the radiation detectors and performs the data acquisition over a number of slices and transmits this data to the host computer. The host computer initiates a scan by sending desired setup parameters to the scanner device and instructing the scanner to begin collecting data. During the scan, acquired data is sent to the host computer and spooled to a hard disk. The computer can be instructed to perform a slice by slice reconstruction of the source brain while the scan is taking place in order to produce a 2-dimensional reconstruction of the mapped brain. A complete 3-dimensional reconstruction of all the compiled slices is performed and visually displayed after acquisition of all the required slices.

Abstract: An brain scanning apparatus having a scanner device and a host computer. The scanner radiation detectors detect radiation emitted from a desired portion, or slice, of a brain source. The scanner device contains microprocessors and code which control the movement of the radiation detectors and performs the data acquisition over a number of slices and transmits this data to the host computer. The host computer initiates a scan by sending desired setup parameters to the scanner device and instructing the scanner to begin collecting data. During the scan, acquired data is sent to the host computer and spooled to a hard disk. The computer can be instructed to perform a slice by slice reconstruction of the source brain while the scan is taking place in order to produce a 2-dimensional reconstruction of the mapped brain. A complete 3-dimensional reconstruction of all the compiled slices is performed and visually displayed after acquisition of all the required slices.

Abstract: Spectrophotometric apparatus and related methodology, including a sensor having a source and at least two receivers of electromagnetic radiation such as red and/or near-infrared light, which is applied non-invasively to the outer periphery of a patient or other animate test subject to examine a particular internal region to which is disposed beyond a peripheral extremity of specifically indeterminant thickness lying immediately inwardly of the outer periphery of the test subject.

Abstract: Methodology and apparatus for the clinical evaluation of biological matter, in particular human anatomy, examined in situ and in vivo, by selective spectral light transmissivity. An optical probe introduces selected light spectra into the examination subject at a first position and resulting light intensity at a second position located some distance from the infusion point is measured; also, light reception preferably occurs at at least one other location, and the effective distances between these locations and the infusion point are determined.

Abstract: An examination instrument for optical apparatus, including a pair of optical heads mounted for relative movement toward and away from one another upon an elongated support, and having means (e.g., an electrical transducer) for producing an electrical signal which is specifically representative of the distance between the optical heads at various positions of relative movement therebetween, for use in analyzing test data obtained by the optical heads. The instrument also includes a test sequence actuation switch disposed in a position where the operator may readily initiate a test sequence without changing his grip upon the instrument as it is held in place on the test subject. The optical heads are mounted on stand-off members which position the heads in spaced relation alongside the elongated support and at an angle relative to one another, to facilitate use on the human breast.

Abstract: Methodology and apparatus for the clinical evaluation of biological matter, in particular human anatomy, examined in situ and in vivo, by selective spectral light transmissivity. An optical probe introduces selected light spectra into the examination subject at a first position and resulting light intensity at a second position located some distance from the infusion point is measured; also, light reception preferably occurs at at least one other location, and the effective distances between these locations and the infusion point are determined.

Abstract: The internal physiological compositional state of an individual examination subject for example a human breast is assessed by transmission of selected light energy spectra into the interior of such subject, detecting the selected spectra after transversal of a distance within the object, quantifying the detected light energy at selected wavelengths, conditioning the obtained value sequence on the basis of distance, determining at least one composite averaged value from the conditioned value, and using such as a characterizing value in comparison with analogously obtained values representative for example of a norm in order to asses the internal state of the subject.

Abstract: The specification discloses a method for determining the nature (e.g., physiological and compositional state) of internal tissue or other such biological material within a human organ or extremity, or other such individual examination subject, by use of selected light energy spectra. The selected light energy is applied to infuse the light throughout the interior of the area to be examined and the relative intensities of the infused light spectra are detected after having traversed the interior of the examination area. The detected intensities are computer-analyzed in a manner which conditions the raw magnitudes initially detected on the basis of the internal distance traversed by the infused light energy and also on the basis of broad averages of such conditioned wavelength-specific detection data representative of a number of comparable examination subjects.

Abstract: The specification discloses apparatus and methodology for calibrating optical-response tissue-examination apparatus of the type having an optical probe with at least one light-sending terminal portion adapted for introducing light into a test subject and a terminal portion for receiving resulting light from such subject. The calibration apparatus includes a body having outer walls which enclose an internal area and define an inlet aperture and an outlet aperture adapted to receive the terminal portions of the optical probe in a manner to substantially preclude entry or exit of ambient light. Means are included within said body for conveying inlet light from the test probe along a tortuous path communicating with the outlet aperture.

Abstract: Methodology and apparatus for the clinical evaluation of biological matter, in particular the human breast, in situ and in vivo, by spectral light transmissivity. An optical probe introduces selected light spectra into the examination subject at a first position and resulting light is detected at a second position located some distance from the infusion point; also, reception preferably occurs at another location, and the distances of these locations from the infusion point are determined. The light energy received at the distant points is quantified and conditioned by use of the determined distances from the infusion point and also by contrasting the data from the two differently-located reception points, such that the resulting data is compensated or normalized to characterize intrinsic internal tissue characteristics in an absolute sense, devoid of individual characteristics such as skin pigmentation, breast thickness, etc.

Abstract: Transverse radionuclide scan field imaging apparatus and method using highly focused collimators in an array surrounding the scan field.

Abstract: A transverse radionuclide scan field imaging apparatus comprises a plurality of highly focused, closely laterally adjacent collimators inwardly focused in a rotatable array which surrounds a scan field, with each collimator being movable relative to its adjacent collimator. For each scan position, the focal point of each collimator uniformly samples at least one half of the scan field.

Abstract: A novel apparatus for and method of measuring product mass is described in which products are sequentially conveyed to an inspection station where the entire bulk of each product is substantially instantaneously irradiated with a beam of radiation. Scattered radiation from the product thus irradiated is detected to provide an electrical signal whose magnitude is representative of the mass of the product. The products can be sorted in accordance with their measured mass.

Abstract: A whole body imaging system rapidly forms a quality image of the bony structure, soft tissue or specific organs of a patient who has been injected with a suitable radioactive tracer chemical. A radiation detector head assembly includes a number of detector subassemblies, each having a lead collimator with tapered holes for admitting gamma radiation from a small area of the patient to a scintillation crystal that converts the gamma rays admitted by the collimator into visible or ultraviolet energy pulses. A photomultiplier converts these pulses into electrical pulses. A row of equally spaced detector subassemblies reciprocate within a nonreciprocating lead shield along the long axis of the array over a distance substantially equal to the separation between adjacent ones of the small areas.