Patents by Inventor Hugh S. Mason
Hugh S. Mason has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10080799Abstract: Disclosed herein are compositions and methods for eliciting immune responses against HCV antigens. In particular embodiments, the compounds and methods elicit immune responses against all or a segment of HCV glycoprotein E1 and/or HCV glycoprotein E2.Type: GrantFiled: February 11, 2011Date of Patent: September 25, 2018Assignee: Arizona Board of Regents on Behalf of Arizona State UniversityInventors: Hugh S. Mason, Seong Hee Bhoo, Sun Hee Rosenthal, Charles J. Arntzen
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Patent number: 9506079Abstract: Plant viral vectors have great potential in rapid production of proteins, but no simple Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.Type: GrantFiled: July 17, 2013Date of Patent: November 29, 2016Assignee: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Hugh S Mason, Zhong Huang, Qiang Chen, Charles J Arntzen, Shuo Yuan, Brooke Hjelm
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Publication number: 20140141515Abstract: Plant viral vectors have great potential in rapid production of proteins, but no simple Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.Type: ApplicationFiled: July 17, 2013Publication date: May 22, 2014Applicant: Arizona Board of Regents for and on behalf of Arizona State UniversityInventors: Hugh S. Mason, Zhong Huang, Qiang Chen, Charles J. Arntzen, Shuo Yuan, Brooke Hjelm
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Publication number: 20140127749Abstract: The invention provides methods for making a target protein in a plant cell, and compositions thereof, wherein the target protein is a recombinant viral glycoprotein.Type: ApplicationFiled: April 23, 2012Publication date: May 8, 2014Applicant: ARIZONA BORAD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZOInventors: Hugh S. Mason, Fan Hong, George Bjorklund
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Patent number: 8513397Abstract: Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.Type: GrantFiled: August 27, 2009Date of Patent: August 20, 2013Assignee: The Arizona Board of Regents for and on behalf of Arizona State UniversityInventors: Hugh S. Mason, Zhong Huang, Qiang Chen, Charles J. Arntzen, Shuo Yuan, Brooke Hjelm
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Publication number: 20130045205Abstract: Disclosed herein are compositions and methods for eliciting immune responses against HCV antigens. In particular embodiments, the compounds and methods elicit immune responses against all or a segment of HCV glycoprotein E1 and/or HCV glycoprotein E2.Type: ApplicationFiled: February 11, 2011Publication date: February 21, 2013Inventors: Hugh S. Mason, Seong Hee Bhoo, Sun Hee Rosenthal, Charles J. Arntzen
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Publication number: 20110262966Abstract: Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.Type: ApplicationFiled: August 27, 2009Publication date: October 27, 2011Applicant: Arizona Board of Regents for and on Behalf of Arizona State UniversityInventors: Hugh S. Mason, Zhong Huang, Qiang Chen, Charles J. Arntzen, Shuo Yuan, Brooke Hjelm
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Patent number: 7879338Abstract: The present invention relates to a synthetic plant-optimized nucleic acid molecule having a Norwalk virus capsid protein coding nucleotide sequence, and nucleic acid constructs, host cells, expression systems, and plants having the plant-optimized Norwalk virus nucleic acid molecule. The present invention also relates to a method of producing Norwalk virus capsid protein virus-like particles in a transgenic plant or transgenic plant seed transformed with a plant-optimized nucleic acid molecule encoding Norwalk virus capsid protein. The plant or a component thereof can be administered to a subject under conditions effective to immunize the subject against disease resulting from infection by a Norovirus, including Norwalk virus. An oral vaccine for immunization of a subject against Norwalk virus infection is also disclosed.Type: GrantFiled: July 21, 2004Date of Patent: February 1, 2011Assignee: Boyce Thompson Institute for Plant ResearchInventors: William D.O. Hamilton, Koen Hellendoorn, Timothy D. Jones, Dwayne D. Kirk, Hugh S. Mason, Xiuren Zhang, Charles J. Arntzen
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Patent number: 7572466Abstract: A method for obtaining an immune response to a non-enteric pathogen antigen (NEPA) such as hepatitis B surface antigen (HBsAg) by feeding the antigen in a plant material to an animal that is immunoreceptive to the NEPA. It has now been discovered that the animal may be made immunoreceptive to the NEPA such as HBsAg by administering the plant material containing the NEPA in conjunction with a suitable adjuvant. The plant material is a substance comprising a physiologically acceptable plant material, especially potatoes, containing the NEPA, e.g. hepatitis B surface antigen (HBsAg). The NEPA, e.g. HBsAg in the plant results from expression by the plant of the NEPA due to genetic alteration.Type: GrantFiled: December 16, 1999Date of Patent: August 11, 2009Assignees: Health Research, Inc., Boyce Thompson Institute for Plant Research, Inc.Inventors: Yasmin Thanavala, Charles Joel Arntzen, Hugh S. Mason
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Patent number: 7527810Abstract: A method for obtaining an immune response to hepatitis B surface antigen (HBsAg) by feeding the antigen in a plant material to an animal that is immunoreceptive to the HBsAg. It has now been discovered that the animal may be made immunoreceptive to HBsAg either by administering the plant material containing HBsAg in conjunction with a suitable adjuvant or by prior primary immunization. When the animal is made immunoreceptive by a prior, e.g. primary, immunization, an immune response to HBsAg may be boosted in the animal by feeding the animal the plant material containing the HBsAg. For example, an animal, e.g. a human, that previously had a positive response to primary immunization against hepatitis B, can have a booster response to HBsAg by feeding the animal the antigen in a plant material. The plant material is a substance comprising a physiologically acceptable plant material, especially potatoes, containing hepatitis B surface antigen (HBsAg).Type: GrantFiled: October 19, 1999Date of Patent: May 5, 2009Assignees: Health Research, Inc., Boyce Thompson Institute for Plant Research, IncInventors: Yasmin Thanavala, Charles Joel Arntzen, Hugh S. Mason
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Patent number: 6770799Abstract: Briefly stated, the invention includes a method of making a transgenic plant that is capable of expressing a physiologically active human acetylcholinesterase, comprising the steps of introducing into at least one plant cell a polynucleotide that encodes a human acetylcholinesterase, and regenerating from the plant cell a transgenic plant that is capable of expressing a physiologically active human acetylcholinesterase in at least one tissue type of the transgenic plant.Type: GrantFiled: March 16, 2001Date of Patent: August 3, 2004Inventors: Tsafrir S. Mor, Hermona Soreq, Charles J. Arntzen, Hugh S. Mason
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Publication number: 20040148657Abstract: Briefly stated, the invention includes a method of making a transgenic plant that is capable of expressing a physiologically active human acetylcholinesterase, comprising the steps of introducing into at least one plant cell a polynucleotide that encodes a human acetylcholinesterase, and regenerating from the plant cell a transgenic plant that is capable of expressing a physiologically active human acetylcholinesterase in at least one tissue type of the transgenic plant.Type: ApplicationFiled: March 3, 2004Publication date: July 29, 2004Inventors: Tsafrir S. Mor, Hermona Soreq, Charles J. Arntzen, Hugh S. Mason
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Publication number: 20040086530Abstract: Plant expression vectors comprising at least two expression cassettes are provided which function to reduce transcriptional silencing of polynucleotide expression. Further, novel plant expression vectors for expression of immunogenic polypeptides, including HBsAg, are provided. The plant expression vectors can be used to produce immunogenic polypeptides, including HBsAg, in edible plant tissues. The edible plant tissues can be used to elicit an immune response in humans and animals when the plant tissues are consumed.Type: ApplicationFiled: January 2, 2003Publication date: May 6, 2004Applicant: Boyce Thompson InstituteInventors: Hugh S. Mason, Yasmin Thanavala, Charles Joel Arntzen, Lizabeth Ritcher
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Publication number: 20030226175Abstract: The present invention provides isolated and purified genes which are differentially expressed during banana fruit development, and the protein products of these genes. The present invention further provides DNA regulatory elements which are differentially expressed during banana fruit development, chimeric genes comprising these DNA regulatory elements operably linked to heterologous DNA molecules, and plants transformed with said chimeric genes, providing for controlled expression of said heterologous DNA molecules during the development and ripening of the fruit of said plants, or in response to exogenous ethylene signals in said plants. The present invention also provides a method for expression of a heterologous protein in fruit comprising transforming fruiting plants with one or more chimeric genes according to the present invention, exposing said fruit to an endogenous or exogenous ethylene signal, and harvesting fruit containing said heterologous protein.Type: ApplicationFiled: June 28, 2001Publication date: December 4, 2003Inventors: Gregory D. May, Stephanie K. Clendennen, Hugh S. Mason, Miguel A. Gomez Lim, Charles J. Arntzen
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Publication number: 20030176653Abstract: The invention provides mutant Escherichia coli heat labile (LT) and Vibrio cholerae toxin (CT) polypeptides and the polynucleotides that encode them. The mutant LT and CT polypeptides can be readily produced in plants and can be used to treat or prevent diseases caused by E. coli and V. cholera. The polypeptides are also useful as adjuvants.Type: ApplicationFiled: December 30, 2002Publication date: September 18, 2003Applicant: Boyce Thompson InstituteInventors: Hugh S. Mason, Charles J. Arntzen
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Patent number: 6551820Abstract: Plant expression vectors comprising at least two expression cassettes are provided which function to reduce transcriptional silencing of polynucleotide expression. Further, novel plant expression vectors for expression of immunogenic polypeptides, including HBsAg, are provided. The plant expression vectors can be used to produce immunogenic polypeptides, including HBsAg, in edible plant tissues. The edible plant tissues can be used to elicit an immune response in humans and animals when the plant tissues are consumed.Type: GrantFiled: December 23, 1999Date of Patent: April 22, 2003Assignee: Boyce Thompson Institute for Plant ResearchInventors: Hugh S. Mason, Yasmin Thanavala, Charles Joel Arntzen, Elizabeth Richter
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Publication number: 20020162140Abstract: Briefly stated, the invention includes a method of making a transgenic plant that is capable of expressing a physiologically active human acetylcholinesterase, comprising the steps of introducing into at least one plant cell a polynucleotide that encodes a human acetylcholinesterase, and regenerating from the plant cell a transgenic plant that is capable of expressing a physiologically active human acetylcholinesterase in at least one tissue type of the transgenic plant.Type: ApplicationFiled: March 16, 2001Publication date: October 31, 2002Inventors: Tsafrir S. Mor, Hermona Soreq, Charles J. Arntzen, Hugh S. Mason
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Patent number: 6395964Abstract: The oral antigens and adjuvants of the present invention are produced in transgenic plants and then administered through the consumption of the transgenic plant. DNA sequences both natural and synthetic encoding for the expression of immunogenic agents which are capable of causing an immune response in animals when fed in edible plants, plant tissues, or derived plant materials are constructed, and plants transformed for stable or transient expression in plant cells. The present invention provides the first known functional method for immunizing animals via transgenic plants, where the plants express bacterial antigens that act as both immunogen and adjuvants when the transgenic plant material expressing the antigens is fed to animals.Type: GrantFiled: August 4, 1997Date of Patent: May 28, 2002Assignees: The Texas A&M University System, The Administrators of the Tulane FundInventors: Charles J. Arntzen, Hugh S. Mason, Haq A. Tariq, John D. Clements
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Patent number: 6392121Abstract: A gene amplification system based on plant viral genetic elements dramatically increases foreign protein production in plants. A safer and more economical production system for vaccines and antibodies in recombinant plants grown using agricultural practice is described. The high-level expression system uses the replicative process of a plant mastrevirus, exemplified by bean yellow dwarf virus (BeYDV). The expression system is preferably inducible to avoid interference with plant growth and development. Developmental cues, such as fruit ripening, are employed to trigger expression of the foreign protein using a tissue-specific promoter. A single, stably integrated expression cassette for foreign protein is replicated extrachromosomally in ripening fruit, forming hundreds of transcriptionally competent copies. Preferred plant hosts include tomato as a model system and soybean for production of large quantities of protein at high total protein levels.Type: GrantFiled: October 7, 1999Date of Patent: May 21, 2002Assignee: Boyce Thompson Institute for Plant ResearchInventors: Hugh S. Mason, Kenneth E. Palmer, Kathleen L. Hefferon, Tsafrir S. Mor, Charles Arntzen
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Patent number: 6194560Abstract: The oral vaccines and oral vaccine adjuvants of the present invention are produced in transgenic plants and then administered through the consumption of the transgenic plant. DNA sequences both natural and synthetic encoding for the expression of immunogenic agents which are capable of causing an immune response in animals when fed in edible plants, plant tissues, or derived plant materials are constructed and plants transformed for stable or transient expression in plant cells. The present invention provides the first known functional method for immunizing animals via transgenic plants, where the plants express bacterial antigens that act as both immunogens and adjuvants when the transgenic plant material expressing the antigens is fed to animals.Type: GrantFiled: November 12, 1998Date of Patent: February 27, 2001Assignee: Texas A & M University SystemInventors: Charles J. Arntzen, Hugh S. Mason, Tariq A. Haq