Abstract: Provided are a read head and methods for reading a multi-layered optical data storage medium comprising a transparent substrate having layers of voxels embedded therein. The read head comprises an imaging system for capturing images of groups of voxels, wherein the read head is configured to bring the imaging system into focus on variable depths in a multi-layered optical data storage medium; and an autofocus system for identifying depth positions of voxels in the multi-layered optical data storage medium by sampling an area in the optical data storage medium. The autofocus system comprises a light source for illuminating the area; and a detector for detecting light from the light source transmitted through the multi-layered optical data storage medium. A method of reading data from a multi-layered optical storage medium comprises capturing, using an imaging system, images of sectors in a first track.

Abstract: A server system comprising processing devices, disks and a storage fabric, all arranged to operate according to a storage fabric protocol in order to communicate between the processing devices and the storage devices over the storage fabric, wherein the storage fabric is settable with a mapping determining which of the processing devices are allocated to use which of the storage devices in providing said services to the client systems. The system comprises a control function arranged to dynamically adapt the mapping in response to either: (i) failure or other downtime of one of the processing devices, storage devices, a component of the storage fabric or a connection in the storage fabric; or (ii) a current demand for the services from the client systems.

Abstract: A transparent substrate that encodes data therein having optically readable identification indicia corresponding to identifying information regarding the substrate. The optically readable identification indicia may be readable from the transparent substrate by altering the reflectivity of the transparent substrate in indicia portions that may be read by a scanner or reader (e.g., a barcode reader). The optically readable identification indicia may be provided on a common surface with a data zone in which data is encoded in the transparent substrate. Alternatively or additionally, the optically readable identification indicia may be provided on another, different surface than the surface on which the data is encoded in a data zone.

Abstract: A server system comprising processing devices, disks and a storage fabric, all arranged to operate according to a storage fabric protocol in order to communicate between the processing devices and the storage devices over the storage fabric, wherein the storage fabric is settable with a mapping determining which of the processing devices are allocated to use which of the storage devices in providing said services to the client systems. The system comprises a control function arranged to dynamically adapt the mapping in response to either: (i) failure or other downtime of one of the processing devices, storage devices, a component of the storage fabric or a connection in the storage fabric; or (ii) a current demand for the services from the client systems.

Abstract: A transparent substrate that encodes data therein having optically readable identification indicia corresponding to identifying information regarding the substrate. The optically readable identification indicia may be readable from the transparent substrate by altering the reflectivity of the transparent substrate in indicia portions that may be read by a scanner or reader (e.g., a barcode reader). The optically readable identification indicia may be provided on a common surface with a data zone in which data is encoded in the transparent substrate. Alternatively or additionally, the optically readable identification indicia may be provided on another, different surface than the surface on which the data is encoded in a data zone.

Abstract: A method of calibrating a polarized light microscope comprises placing an optical data storage medium in a sample stage of the polarized light microscope, the optical data storage medium comprising a substrate having birefringent voxels embedded therein; measuring a background birefringence of the optical data storage medium; adjusting the polarized light microscope to compensate for the background birefringence. By correcting for background birefringence, image contrast may be improved. Further improvements may be obtained by optimizing swing angles of measurement states after compensating for the background birefringence. Also provided is a method of reading data from a birefringent optical data storage medium, and a system useful for implementing the methods.

Abstract: A storage library system comprises a plurality of slots for storing items, a plurality of rails, and a robot for interacting with said items. The robot has at least two foot arrangements each having a respective gripping mechanism for releasably engaging that foot arrangement with the rails. The robot also has a transfer mechanism for moving the robot, while a first one or more of the foot arrangements remains engaged with a first of the rails, from a first position in which one or more of the foot arrangements is in abutment with a second of the rails to a second position in which one or more of the foot arrangements is in abutment with a third of the rails. The robot also has an end-effector for interacting with the items in the slots.

Abstract: A meter reading system comprises a sensor unit (2) containing a first camera (10) and at least a second camera (10?), the first camera focussed on a first area of a meter display (32) and the said second camera focussed on a second area of the meter display (32), the cameras arranged so that the area consisting of said first and second areas can be captured.

Abstract: Described is a process for producing a mutant bacterium which exhibits improved survival and/or growth under a selected growth condition, the process comprising the steps of: (a) generating a pool of mutant bacteria by transposon mutagenesis with an activating transposon (TnA), wherein the TnA comprises a promoter capable of increasing transcription of a gene at or near its insertion site; (b) growing bacteria from the mutant pool under the selected growth condition and under one or more reference conditions to produce two or more test cultures; and (c) comparing the distribution of TnA insertions between test cultures to identify a first class of genes which are disadvantageous for growth and/or survival under the selected growth condition and a second class of genes which are advantageous for growth and/or survival under the selected growth condition.

Abstract: A transparent substrate that encodes data therein having optically readable identification indicia corresponding to identifying information regarding the substrate. The optically readable identification indicia may be readable from the transparent substrate by altering the reflectivity of the transparent substrate in indicia portions that may be read by a scanner or reader (e.g., a barcode reader). The optically readable identification indicia may be provided on a common surface with a data zone in which data is encoded in the transparent substrate. Alternatively or additionally, the optically readable identification indicia may be provided on another, different surface than the surface on which the data is encoded in a data zone.

Abstract: A transparent substrate that encodes data therein having optically readable identification indicia corresponding to identifying information regarding the substrate. The optically readable identification indicia may be readable from the transparent substrate by altering the reflectivity of the transparent substrate in indicia portions that may be read by a scanner or reader (e.g., a barcode reader). The optically readable identification indicia may be provided on a common surface with a data zone in which data is encoded in the transparent substrate. Alternatively or additionally, the optically readable identification indicia may be provided on another, different surface than the surface on which the data is encoded in a data zone.

Abstract: Disclosed are methods related to identifying an essential gene which serves as an antibiotic target in a bacterium.

Abstract: Disclosed are methods related to identifying an essential gene which serves as an antibiotic target in a bacterium.

Abstract: Described is a method for screening an encoded chemical library, which library comprises a plurality of different chemical structures each releasably linked to an encoding tag, the method comprising the steps of: (a) providing said library of tagged chemical structures; (b) releasing each chemical structure from its tag to produce a plurality of free, tagless chemical structures (TCSs); (c) screening the TCSs by contacting them with a assay system under conditions whereby a spatial association between each TCS and its tag is maintained, to produce a plurality of different screened TCSs each spatially associated with its tag; and (d) identifying a screened TCS by decoding a tag that is spatially associated therewith.

Abstract: A server system comprising storage devices, processing devices and a storage fabric all operating according to a storage fabric protocol. The storage fabric comprises a plurality of individual switches having a modular design from which an overall switch is built, and the individual switches have individual respective configuration settings which determine which processing devices are allocated to use which of the storage devices. The system comprises an API enabling a software control function to configure the overall switch. The API is operable to receive from the control function an overall mapping of the storage devices to the processing devices instead of requiring the individual configuration settings of each of the individual switches to be specified by the control function, the API being configured to convert the overall mapping into the individual configuration settings of the individual switches to produce the overall mapping.

Abstract: Disclosed is an encoded chemical library microbead, which microbead has immobilized thereon and/or therein: (i) an encoding tag; and (ii) a target assay system reporter moiety, wherein the reporter moiety exists in a first state in the absence of activity against the target and in a second state in the presence of said activity, and wherein said microbead further comprises a clonal population of one or more chemical structure(s) releasably linked thereto and encoded by said tag.

Abstract: Methods and apparatus to align and couple aircraft are disclosed. An example apparatus for securing a first aircraft to a second aircraft includes a guide to direct movement of a first wing of the first aircraft relative to a second wing of the second aircraft to align the first wing with the second wing, and a lock configured to couple the first wing to the second wing after the guide aligns the first wing to the second wing.

Abstract: The present invention provides an apparatus for conducting an assay in a microfluidic system comprising magnetic beads, said apparatus comprising: a platform upon which a microfluidic system can be mounted, one or more actuators having a magnet, configured to directly influence movement of magnetic beads housed within a microfluidic system when a microfluidic system is mounted on said platform, and a control means configured to control relative movement of the one or more magnets, and a microfluidic system when mounted, to enable the magnet to trace a desired path across a mounted microfluidic system, said magnet being positionable at any x- and y-coordinates of a mounted microfluidic system, wherein said apparatus further comprises: a) at least one rotary actuator configured to enable magnet movement in an x-axis, and/or b) a means for moving a mounted microfluidic system in a stepwise fashion.

Abstract: A transparent substrate that encodes data therein having optically readable identification indicia corresponding to identifying information regarding the substrate. The optically readable identification indicia may be readable from the transparent substrate by altering the reflectivity of the transparent substrate in indicia portions that may be read by a scanner or reader (e.g., a barcode reader). The optically readable identification indicia may be provided on a common surface with a data zone in which data is encoded in the transparent substrate. Alternatively or additionally, the optically readable identification indicia may be provided on another, different surface than the surface on which the data is encoded in a data zone.

Abstract: A server system comprising storage devices, processing devices and a storage fabric all operating according to a storage fabric protocol. The storage fabric comprises a plurality of individual switches having a modular design from which an overall switch is built, and the individual switches have individual respective configuration settings which determine which processing devices are allocated to use which of the storage devices. The system comprises an API enabling a software control function to configure the overall switch. The API is operable to receive from the control function an overall mapping of the storage devices to the processing devices instead of requiring the individual configuration settings of each of the individual switches to be specified by the control function, the API being configured to convert the overall mapping into the individual configuration settings of the individual switches to produce the overall mapping.