Patents by Inventor Hugo Gramajo

Hugo Gramajo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineering polyketide synthase in cyanobacteria
    Patent number: 11274324
    Abstract: Provided herein, inter alia, is a modular-functional technology for the expression of a functional heterologous polyketide synthases (PKS) system in a photosynthetic cyanobacteria.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: March 15, 2022
    Assignee: The Regents of the University of California
    Inventors: Michael D. Burkart, Jeffrey Mindrebo, James Golden, Arnaud Taton, Julia Roulet, Hugo Gramajo, Ana Arabolaza
  • ENGINEERING POLYKETIDE SYNTHASE IN CYANOBACTERIA
    Publication number: 20200332324
    Abstract: Provided herein, inter alia, is a modular-functional technology for the expression of a functional heterologous polyketide synthases (PKS) system in a photosynthetic cyanobacteria.
    Type: Application
    Filed: March 27, 2020
    Publication date: October 22, 2020
    Inventors: Michael D. Burkart, James Golden, Amaud Taton, Julia Roulet, Hugo Gramajo, Ana Arabolaza
  • Engineered organisms for production of novel lipids
    Patent number: 10119145
    Abstract: The present disclosure provides engineered microorganisms, engineered biosynthetic pathways, methods of producing lipid compounds using genetically engineered microorganisms, and the products synthesized by those organisms. In particular, the disclosure provides genetically engineered microorganisms for the production of multi-methyl branched fatty acids (MMBFAs) and MMBFA esters (wax esters) derived from these fatty acids. In addition, the disclosure provides methods for producing acylglycerols with one of more of their acyl substituents being an MMBFA, and methods for producing alcohols derived from MMBFAs (fatty alcohols).
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 6, 2018
    Assignee: CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET)
    Inventors: Hugo Gramajo, Ana Arabolaza, Santiago Comba, Simón Menendez-Bravo, Héctor Álvarez
  • Engineered Organisms for Production of Novel Lipids
    Publication number: 20160053271
    Abstract: The present disclosure provides engineered microorganisms, engineered biosynthetic pathways, methods of producing lipid compounds using genetically engineered microorganisms, and the products synthesized by those organisms. In particular, the disclosure provides genetically engineered microorganisms for the production of multi-methyl branched fatty acids (MMBFAs) and MMBFA esters (wax esters) derived from these fatty acids. In addition, the disclosure provides methods for producing acylglycerols with one of more of their acyl substituents being an MMBFA, and methods for producing alcohols derived from MMBFAs (fatty alcohols).
    Type: Application
    Filed: March 14, 2014
    Publication date: February 25, 2016
    Inventors: Hugo GRAMAJO, Ana ARABOLAZA, Santiago COMBA, Simón MENENDEZ- BRAVO, Héctor ÁLVAREZ
  • Recombinant genes for polyketide modifying enzymes
    Patent number: 7427493
    Abstract: Materials and methods to produce modified polyketides are disclosed. The biosynthesis, transfer and regulator genes for various sugars to effectuate polyketide modification are disclosed.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: September 23, 2008
    Assignee: Kosan Biosciences Incorporated
    Inventors: C. Richard Hutchinson, Leonard Katz, Ralph Reid, Zhihao Hu, Hugo Gramajo
  • Production of glycosylated macrolides in E. coli
    Publication number: 20050287587
    Abstract: Methods and materials are provided for E. coli host cells containing an expression system for producing NDP 6-deoxy-sugar, which may also comprise an expression system for expressing 6-deoxyglycosyl transferase and/or an expression system for producing a polyketide and/or polyketide oxidation enzymes.
    Type: Application
    Filed: August 12, 2005
    Publication date: December 29, 2005
    Inventors: Chaitan Khosla, Hugo Gramajo, Kinya Hotta, Seiji Kobayashi
  • Production of glycosylated macrolides in E. coli
    Publication number: 20040214276
    Abstract: Methods and materials are provided for E. coli host cells containing an expression system for producing NDP 6-deoxy-sugar, which may also comprise an expression system for expressing 6-deoxyglycosyl transferase and/or an expression system for producing a polyketide and/or polyketide oxidation enzymes.
    Type: Application
    Filed: July 31, 2003
    Publication date: October 28, 2004
    Inventors: Chaitan Khosla, Hugo Gramajo, Kinya Hotta, Seiji Kobayashi
  • Recombinant genes for polyketide modifying enzymes
    Publication number: 20040203015
    Abstract: Materials and methods to produce modified polyketides are disclosed. The biosynthesis, transfer and regulator genes for various sugars to effectuate polyketide modification are disclosed.
    Type: Application
    Filed: June 30, 2003
    Publication date: October 14, 2004
    Inventors: C. Richard Hutchinson, Leonard Katz, Ralph Reid, Zhihao Hu, Hugo Gramajo