Abstract: The invention provides a method for detecting KRAS mutations at one or more of codons, said method comprising the steps of: (a) extracting DNA from a biological sample; (b) assaying the DNA via PCR for KRAS mutations at one or more of codons with at least one set of oligonucleotides, wherein the at least one set of oligonucleotides comprises an allele specific forward primer, a reverse primer, a probe and a xenonucleic acid clamp to block amplification of wild type DNA. The xenonucleic acid clamps have aza-aza, thio-aza and oxy-aza chemical functionality.

Abstract: An osteotomy calibration method, calibration device, and an orthopedic surgery system are provided by present application. Firstly using the osteotomy calibration device to obtain the calculated position information of the current osteotomy plane, and then determining a position error between the calculated position information and a predetermined position information of a planned osteotomy plane, and if the position error exceeds a preset value, calculating and transmitting a relocation information to a robotic arm to control and relocate the robotic arm. By comparing and identifying the position error between the current osteotomy plane formed by the first osteotomy and the planned predetermined osteotomy plane, relocating the robotic arm, and performing a secondary correction of the osteotomy plane. In addition, by relocating the robotic arm and secondary correction of the osteotomy plane, additional bone nails which is to fix the navigation tool to the bone can be avoided.

Abstract: In the present disclosure, methods, apparatuses, devices and media are provided for generating a video in a text mode in an information sharing application. In a method, a request is received for generating the video from a user of the information sharing application. An initial page is displayed for generating the video in the information sharing application, the initial page comprising an indication for entering text. Text input is obtained from the user in response to detection of a touch by the user in an area where the initial page locates. A video to be published in the application is generated based on the text input. In some examples, within the information sharing application, the user may directly generate a corresponding video based on a text input. In this way, a complexity of user operation may be reduced, and the user may be provided with richer publishing content.

Abstract: A method for controlling a traffic light, a method and apparatus for navigating an unmanned vehicle and a method and apparatus for training a model are provided. An implementation comprises: generating a reinforced traffic light state parameter according to vehicle state representation information of an unmanned vehicle currently contained in a preset area of a target traffic light and a current traffic light state parameter of the target traffic light; and generating a traffic light control action according to the reinforced traffic light state parameter; where the reinforced traffic light state parameter is used to cause an unmanned vehicle navigation end to generate a reinforced vehicle state parameter according to a reinforced traffic light state and a current vehicle state parameter of a target unmanned vehicle, and generate an unmanned vehicle navigation action according to the reinforced vehicle state parameter.

Abstract: A disclosed database system and enhanced methods implement enhanced mini-plans and dynamically changing a query mini-plan with trustworthy Artificial Intelligence (AI) to improve query execution performance in a database system. An AI cost model evaluates candidate mini-plans for executing a query. AI truth monitors evaluate the execution of the mini-plans, such as predicted input factors and adjusted mini-plans of one or more AI running data models. The AI truth monitors provide feedback to adjust the AI cost model based on evaluating the execution of the mini-plans. The AI truth monitors validate adjusted mini-plans, provide feedback to the AI cost model with improved overall prediction accuracy, and enhanced mini-plans to gain query performance.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: An embodiment includes generating a partition schema for a distributed database based on historical usage data indicative of usage of the distributed database, where the generating of the partition schema comprises determining a partition range of a partition of the partition schema. The embodiment also includes generating a node identifier for the partition using a hash function and a first weight value assigned to the partition. The embodiment also includes monitoring performance data indicative of a performance of the distributed database, the monitoring comprising detecting a failure of the performance to satisfy a performance threshold. The embodiment also includes initiating, responsive to detecting the failure, a redistribution procedure by changing the node identifier of the partition by replacing the first weight value with a second weight value.

Abstract: The present disclosure relates to a video sharing method and apparatus, a device, and a medium. The video sharing method includes: displaying a target object in a target interactive interface, the target object comprising at least one among a target video to be shared or a sharing control of a target video, wherein the target video is a historically posted video; when a first trigger operation on the target object is detected, displaying a preset playing interface, a composite video used for sharing the target video being displayed within the preset play interface, the composite video comprising the target video and visual material, and the visualization material being generated according to the target video.

Abstract: The present disclosure relates to an audio sharing method and apparatus, a device, and a medium. The audio sharing method comprises: displaying a target object in a target interaction interface, the target object comprising an original video using a target audio to be shared as a background music and/or a sharing control of the target audio, and the target audio being a posted audio; when a first trigger operation on the target object is detected, displaying a preset playing interface, the preset playing interface displaying a target video using the target audio as background music, the target video being used for sharing the target audio, and the target video comprising a visual material generated according to the target audio.

Abstract: The disclosure provides compounds, and compositions, including pharmaceutical compositions, kits that include the compounds, and methods of using (or administering) and making the compounds. The disclosure further provides compounds or compositions thereof for use in a method of modulating PLXDC1 (TEM7) and/or PLXDC2 or killing pathogenic blood vessles. The disclosure further provides compounds or compositions thereof for use in a method of treating a disease, disorder, or condition that is mediated, at least in part, by PEDF receptors or by angiogenesis.

Abstract: The invention relates to methods of increasing sensitivity of an epidermal growth factor receptor (EGFR)-related cancer to EGFR tyrosine kinase inhibitor (TKI) comprising administering a therapeutically effective amount of EGFR isoform D to a subject in need thereof. The invention also relates to methods of treating a subject suffering from an EGFR-related cancer comprising administering to the subject an effective amount of EGFR isoform D and a TKI. In one embodiment, the EGFR-related cancer is head and neck squamous cell carcinoma (HNSCC).

Abstract: A heat flux sensor, comprising: a ceramic heat sink; a sensitive element made of a single-crystal material and fixed to the ceramic heat sink through a thermally conductive and electrically insulative adhesive; a heat absorption layer arranged on an upper surface of the sensitive element; a first metal electrode and a second metal electrode arranged on the upper surface of the sensitive element; a third metal electrode arranged on the upper surface of the sensitive element; a fourth metal electrode arranged on a lower surface of the sensitive element; and a fifth metal electrode arranged on an upper surface of the ceramic heat sink; wherein a voltage signal between the first metal electrode and the second metal element is a transverse voltage Ux, and a voltage signal between the third metal electrode and the fourth metal electrode is a longitudinal voltage Uz.

Abstract: A mapping method for right-turn conflict warning lines at urban road intersections includes: obtaining the conflict data of urban intersections and the driving trajectory information of large vehicles and obtaining the outermost rear wheel trajectory curve and the innermost rear wheel trajectory curve through the driving trajectory information of large vehicles; using the regression model to construct the dynamic model of the right-turn conflict area of large vehicles and obtain the relationship between the parameters of the outermost rear wheel trajectory curve and the innermost rear wheel trajectory curve and the dynamic and static indexes; inputting the dynamic and static indexes of other road intersections into the dynamic model of the right-turn conflict area of large vehicles to obtain the corresponding outermost rear wheel trajectory curve and the innermost rear wheel trajectory curve, and drawing the urban road warning line.

Abstract: Side handle for an electric hand-held power tool, wherein the side handle has a grip region designed to be gripped by a user, and a clamping unit, by which the side handle can be releasably fastened to a machine neck of the hand-held power tool, wherein the clamping unit has an operating element, by which the clamping unit is able to be clamped and unclamped, wherein the operating element, when the clamping unit is in the clamped state, is substantially flush with the surface of the grip region. The operating element is preferably in the form of a clamping lever.

Abstract: A ceramic electronic component includes a body, including a dielectric layer and an internal electrode, and an external electrode disposed on the body and connected to the internal electrode. At least a region of the dielectric layer includes tin (Sn) and a lanthanide rare earth element (RE) including dysprosium (Dy). In the at least a region of the dielectric layer, a molar ratio of tin (Sn) to dysprosium (Dy) is from 0.15 to 0.30.

Abstract: A polyacrylamide-based symmetric branched polymer surfactant and a process for preparing the same and use thereof are provided. The surfactant has an acrylamide structure unit, an anionic monomer structure unit, an optional non-ionic monomer structure unit, a branched structure unit, and an optional cationic monomer structure unit. The branched structure unit has at least one of structures represented by formula (1) or formula (2): The polymer surfactant can realize both the high viscosity of the aqueous solution and the low oil water interfacial tension, and can be used as the oil displacement agent in the tertiary oil recovery.