Abstract: The present disclosure belongs to a field of biomedical imaging technology, and in particularly to a non-uniform excitation field-based method and system for performing a magnetic nanoparticle imaging. The present disclosure includes: separating the non-uniform excitation field into independent space and current time functions by a spatialtemporal separation method; calculating a normalized signal peak through the current time function; constructing a reconstruction mathematical model based on the normalized signal peak and an imaging subunit volume; and quantitatively reconstructing a spatial distribution of a nanoparticle by combining the normalized signal peak, a non-uniform spatial function of the excitation field and the reconstruction mathematical model, so as to achieve the magnetic nanoparticle imaging of a to-be-reconstructed object.

Abstract: The present disclosure provides a switching current source circuit and a method for quickly establishing a switching current source. The switching current source circuit includes a first and a second switching current source branches connected in parallel with one end of a load. When the switching enable signal is switched, due to the charge coupling of the first and second switching current source branches, the bias voltage respectively generates bounce in the same direction as and a direction opposite to the transition direction of the switching enable signal. The two bounces cancel each other to make the current source bias voltage recover quickly when a toggle event happens. The present disclosure accelerates the establishment of current through the coupling of charges, and reduces the decoupling capacitance at the same time, thereby reducing the circuit area and saving the costs.

Abstract: A semiconductor device includes: a substrate comprising a magnetic tunneling junction (MTJ) region and a logic region, a MTJ on the MTJ region, a top electrode on the MTJ, a connecting structure on the top electrode, and a first metal interconnection on the logic region. Preferably, the first metal interconnection includes a via conductor on the substrate and a trench conductor, in which a bottom surface of the trench conductor is lower than a bottom surface of the connecting structure.

Abstract: A vulcanizing agent is added during the processing of a polymer, and can form a crosslinking structure network in the polymer, thereby improving the mechanical properties of the material. Furthermore, the crosslinking agent can also de-crosslink the polymer material at a high temperature, and after being cooled, same can be crosslinked again to produce a network structure, thus endowing the polymer material with thermoplasticity for repeated processing.

Abstract: The present invention discloses an SOC PMUT suitable for high-density system integration, an array chip and a manufacturing method thereof. With the SOC PMUT suitable for high-density system integration, vertical stacking and monolithic integration of a SOC PMUT array with CMOS auxiliary circuits is realized by means of direct bonding of active wafers and a vertical multi-channel metal wiring structure; in addition, the extension to the package layer is implemented by means of TSVs, without any bonding mini-pad on the periphery of the array for communication with the CMOS. Thus, the bottleneck of metal interconnections in conventional ultrasonic transducers is overcome, the chip area occupied by metal interconnections in ultrasonic transducers is greatly reduced, the metal wiring length is reduced, thus the resulting adverse effects of an electrical parasitic effect on the performance of the ultrasonic transducer array are reduced.

Abstract: The present disclosure relates to a system and method for locating a target subject associated with an X-ray system. The X-ray system may include an X-ray source, a detection component, an arm, and a platform. The X-ray system may also include a first positioning component, a second positioning component, or a third positioning component. The first positioning component may be configured to determine a target point where a region of interest (ROI) of the target subject locates. The second positioning component may be configured to locate the target subject. The third positioning component may be configured to obtain location information of a target device associated with the target subject in real-time.

Abstract: A manufacturing method of a semiconductor device includes the following steps. A first inter-metal dielectric (IMD) layer is formed on a substrate. A cap layer is formed on the first IMD layer. A connection structure is formed on the substrate and penetrates the cap layer and the first IMD layer. A magnetic tunnel junction (MTJ) stack is formed on the connection structure and the cap layer. A patterning process is performed to the MTJ stack for forming a MTJ structure on the connection structure and removing the cap layer. A spacer is formed on a sidewall of the MTJ structure and a sidewall of the connection structure. A second IMD layer is formed on the first IMD layer and surrounds the MTJ structure. The dielectric constant of the first IMD layer is lower than the dielectric constant of the second IMD layer.

Abstract: The present invention provides piperidin-4-y1 azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Abstract: A semiconductor device includes a magnetic tunneling junction (MTJ) on a substrate, a spacer adjacent to the MTJ, a liner adjacent to the spacer, and a first metal interconnection on the MTJ. Preferably, the first metal interconnection includes protrusions adjacent to two sides of the MTJ and a bottom surface of the protrusions contact the liner directly.

Abstract: The present disclosure includes: transforming a time-domain voltage signal collected by an MPI system device to a frequency domain; calculating a square root of a square sum of a real part and an imaginary part at each frequency point of a frequency domain signal; arranging acquired amplitudes in a descending order, and acquiring a screening threshold by an amplitude ratio method; screening an amplitude through the screening threshold and constructing frequency domain signal data; acquiring a row vector of a system matrix corresponding to each frequency point of the data, so as to construct an update system matrix; and solving, based on the frequency domain signal array and the update system matrix, an inverse problem in a form of a least square based on an L2 constraint to obtain a three-dimensional magnetic particle concentration distribution result, so as to achieve a fast reconstruction of the MPI system.

Abstract: There are provided bivalent compounds and conjugates thereof, the conjugates comprising a bivalent compound, a targeting moiety, and a bioactive agent, as well as pharmaceutical compositions and methods of use of the conjugate for the treatment, inhibition, or prevention of diseases and disorders which are therapeutic targets of the bioactive agent.

Abstract: A method for fabricating a magnetic random access memory (MRAM) device includes the steps of first forming a first magnetic tunneling junction (MTJ) on a substrate, forming a first top electrode on the first MTJ, and then forming a passivation layer around the first MTJ. Preferably, the passivation layer includes a V-shape and a valley point of the V-shape is higher than a top surface of the first top electrode.

Abstract: The present invention discloses a method and system for training a passenger distribution prediction model, and a method and system for guiding passengers. In an embodiment, the passenger distribution is intelligently sensed by means of the characteristics of temperature, humidity and CO2 concentration distribution changes in cars caused by passenger density changes, which avoids the problems of crowd flow and obscuration faced by passenger distribution detection conducted with images, and avoids the difficulty in floor intrusive transformation faced by passenger distribution detection conducted with pressure sensors; the passenger flow is guided by adjusting the brightness of lighting tubes in the cars, for example, the lighting tubes in areas with high passenger density are dimmed, and the lighting tubes in areas with low passenger density are brightened, to guide ordered flow of passengers toward areas with low passenger density. Further details are disclosed herein.

Abstract: A tactile reproduction device, a method for driving the same, and a tactile reproduction apparatus. Tactile reproduction device may simulate textures to implement tactile reproduction. tactile reproduction device includes a plurality of piezoelectric units, includes: first electrode, piezoelectric section, and second electrode which are laminated, wherein the second electrode includes: first comb electrode and second comb electrode; the first comb electrode includes: a plurality of first comb-teeth electrodes and a first comb-shank electrode connecting the plurality of first comb-teeth electrodes; the second comb electrode includes: a plurality of second comb-teeth electrodes and a second comb-shank electrode connecting the plurality of second comb-teeth electrodes; the plurality of first comb-teeth electrodes and the plurality of second comb-teeth electrodes are mutually intersected; the first electrode includes a plurality of electrode units which are not connected to each other.

Abstract: A manufacturing method of a semiconductor device includes the following steps. A first inter-metal dielectric (IMD) layer is formed on a substrate. A cap layer is formed on the first IMD layer. A connection structure is formed on the substrate and penetrates the cap layer and the first IMD layer. A magnetic tunnel junction (MTJ) stack is formed on the connection structure and the cap layer. A patterning process is performed to the MTJ stack for forming a MTJ structure on the connection structure and removing the cap layer. A spacer is formed on a sidewall of the MTJ structure and a sidewall of the connection structure. A second IMD layer is formed on the first IMD layer and surrounds the MTJ structure. The dielectric constant of the first IMD layer is lower than the dielectric constant of the second IMD layer.

Abstract: A method for fabricating semiconductor device includes the steps of: forming a first magnetic tunneling junction (MTJ) on a substrate; forming a first liner on the MTJ; forming a second liner on the first liner; forming an inter-metal dielectric (IMD) layer on the MTJ, and forming a metal interconnection in the IMD layer, the second liner, and the first liner to electrically connect the MTJ. Preferably, the first liner and the second liner are made of different materials.

Abstract: A magnetoresistive random access memory (MRAM) device includes a first array region and a second array region on a substrate, a first magnetic tunneling junction (MTJ) on the first array region, a first top electrode on the first MTJ, a second MTJ on the second array region, and a second top electrode on the second MTJ. Preferably, the first top electrode and the second top electrode include different nitrogen to titanium (N/Ti) ratios.

Abstract: A semiconductor device includes a substrate comprising a MTJ region and a logic region, a magnetic tunneling junction (MTJ) on the MTJ region, and a contact plug on the logic region. Preferably, the MTJ includes a bottom electrode layer having a gradient concentration, a free layer on the bottom electrode layer, and a top electrode layer on the free layer.

Abstract: Methods, computer program products, and/or systems are provided that perform the following operations: obtaining video data; dividing the video data into a plurality of video fragments based, at least in part, on page detection; extracting one or more elements from each of the plurality of video fragments; determining element type data for each of one or more extracted elements; generating element style data for the one or more extracted elements; determining page flow for the plurality of video fragments; and generating one or more pages based, at least in part, on the one or more elements extracted from the plurality of video fragments, the element type data, the element style data, and the page flow.

Abstract: Implementations of the present disclosure provide coloring methods that sort and pre-color nodes of G0-linked networks in a multiple-patterning technology (MPT)-compliant layout design by coordinate. In one embodiment, a method includes identifying target networks in a circuit layout, each target network having two or more linked nodes representing circuit patterns, and each target network being presented in an imaginary X-Y coordinate plane, assigning a first feature to a first node in each target network, the first node is determined using a coordinate-based method, and assigning the first feature and a second feature to remaining nodes in each target network in an alternating manner so that any two immediately adjacent linked nodes in each target network have different features.