Patents by Inventor Huihe Zhu

Huihe Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the manufacture of oligonucleotides
    Patent number: 8513404
    Abstract: A process for manufacturing an oligonucleotide which comprises removing ?-eliminating phosphorus-protecting groups, in particular ?-cyanoethyl protective groups from a protected oligonucleotide, wherein said removing comprises contacting the protected oligonucleotide with an amine solution in a solvent which preferably does not consist of pyridine, wherein the conjugate acid of the amine has preferably a pKa of greater than 11.5, and wherein the concentration of the amine in the solution is less than 0.5 mole/liters.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: August 20, 2013
    Assignee: Nitto Denko Avecia, Inc.
    Inventors: Tadeusz Krzysztof Wyrzykiewicz, Hagen Cramer, Huihe Zhu, Kevin James Finn
  • Process for the manufacture of oligonucleotides
    Publication number: 20110087014
    Abstract: A process for manufacturing an oligonucleotide which comprises removing ?-eliminating phosphorus-protecting groups, in particular ?-cyanoethyl protective groups from a protected oligonucleotide, wherein said removing comprises contacting the protected oligonucleotide with an amine solution in a solvent which preferably does not consist of pyridine, wherein the conjugate acid of the amine has preferably a pKa of greater than 11.5, and wherein the concentration of the amine in the solution is less than 0.5 mole/liters.
    Type: Application
    Filed: April 24, 2009
    Publication date: April 14, 2011
    Applicant: GIRINDUS AMERICA, INC.
    Inventors: Tadeusz Krzysztof Wyrzykiewicz, Hagen Cramer, Huihe Zhu, Kevin James Finn