Patents by Inventor Hung-Chieh Chou
Hung-Chieh Chou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250038073Abstract: A package structure and a method for forming the same are provided. The package structure includes a first package structure and a second package structure. The first package structure includes a first device formed over a first substrate. The first device includes a first conductive plug connected to a through substrate via (TSV) structure formed in the first substrate. A buffer layer surrounds the first substrate. A first bonding layer is formed over the first substrate and the buffer layer. The second package structure includes a second device formed over a second substrate. A second bonding layer is formed over the second device. A hybrid bonding structure is between the first package structure and the second package structure by bonding the first bonding layer to the second bonding layer.Type: ApplicationFiled: July 27, 2023Publication date: January 30, 2025Applicant: Taiwan Semiconductor Manufacturing Company, Ltd.Inventors: Ke-Han SHEN, Chih-Yuan CHEN, Jiung WU, Hung-Yi Kuo, Chung-Ju LEE, Tung-He CHOU, Ji CUI, Kuo-Chung YEE, Chen-Hua YU, Cheng-Chieh HSIEH, Yu-Jen LIEN, Yian-Liang KUO, Shih-Hao TSENG, Jen Yu WANG, Tzu-Chieh Chou
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Publication number: 20230391838Abstract: ?-RgIA4 peptide analogs, compositions therewith, and methods for their treatment and use are disclosed and described. For example, an ?-RgIA4 peptide analog can comprise a recognition finger region configured to bind to an ?9?10 nicotinic acetylcholine receptor, and a side chain bonding configuration that protects an inter-cysteine sulfur linkage.Type: ApplicationFiled: June 3, 2021Publication date: December 7, 2023Inventors: Joseph Michael McIntosh, Nan Zheng, Hung-Chieh Chou
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Publication number: 20230381329Abstract: Disclosed herein, are Zwitterion polymer conjugates. The conjugate comprises a Zwitterion polymer, a linker, and a therapeutic polypeptide. Also described herein, are compositions comprising the conjugates, methods of their preparation, methods of treating diseases with the conjugates or their compositions, and method of preventing aggregation of therapeutic proteins.Type: ApplicationFiled: May 26, 2023Publication date: November 30, 2023Inventors: Jessica Kramer, Danny Hung-Chieh Chou
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Publication number: 20220389073Abstract: Disclosed are peptides comprising an insulin A chain peptide and an insulin B chain peptide, wherein the B chain peptide comprises a substitution at amino acid 10 and amino acid 20. Disclosed are methods of increasing insulin receptor activation in a subject comprising administering a therapeutically effective amount of a disclosed peptide. Disclosed are methods of lowering the blood sugar in a subject comprising administering a therapeutically effective amount of a disclosed peptide. Disclosed are methods of treating type 1 diabetes in a subject comprising administering a therapeutically effective amount of a disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: October 23, 2020Publication date: December 8, 2022Inventors: Danny Hung-Chieh Chou, Helena Safavi-Hemami
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Publication number: 20220340636Abstract: The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.Type: ApplicationFiled: January 4, 2022Publication date: October 27, 2022Inventors: John Gerbrandt Tasman MENTING, Brian SMITH, Danny Hung-Chieh CHOU, Helena SAFAVI-HEMAMI, Michael Colin LAWRENCE, Baldomero M. OLIVERA
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Patent number: 11248034Abstract: The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.Type: GrantFiled: July 21, 2017Date of Patent: February 15, 2022Assignees: University of Utah Research Foundation, The Walter and Eliza Hall Institute of Medical ResearchInventors: John Gerbrandt Tasman Menting, Brian Smith, Danny Hung-Chieh Chou, Helena Safavi-Hemami, Michael Colin Lawrence, Baldomero M. Olivera
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Patent number: 11155577Abstract: In one aspect, the invention relates to compositions comprising stapled peptides, methods of making same, pharmaceutical compositions comprising same, and methods of treating various diseases, including, but not limited to, metabolic disorders such as diabetes, and cancers. The disclosed compounds comprise stapled peptides, including, but not limited to, stapled glucagon, axin, and p53 peptide homologues, which are useful as therapeutic agents for a variety of diseases as disclosed herein. The disclosed methods are useful in the preparation of a variety of stapled peptides, including stapled peptide homologues of glucagon, axin, and p53. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: June 22, 2016Date of Patent: October 26, 2021Assignee: University of Utah Research FoundationInventors: Danny Hung-Chieh Chou, Yuanxiang Wang
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Publication number: 20210214412Abstract: The present disclosure is concerned with insulin-based peptides, methods of making the peptides, and methods of treating diabetes using these peptides. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: April 15, 2019Publication date: July 15, 2021Inventor: Danny Hung-Chieh Chou
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Patent number: 11034720Abstract: In one aspect, the invention relates to compositions comprising stapled peptides, methods of making same, pharmaceutical compositions comprising same, and methods of treating various diseases, including, but not limited to, metabolic disorders such as diabetes, and cancers. The disclosed compounds comprise stapled peptides, including, but not limited to, stapled glucagon, axin, and p53 peptide homologues, which are useful as therapeutic agents for a variety of diseases as disclosed herein. The disclosed methods are useful in the preparation of a variety of stapled peptides, including stapled peptide homologues of glucagon, axin, and p53. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: July 17, 2017Date of Patent: June 15, 2021Assignee: University of Utah Research FoundationInventors: Danny Hung-Chieh Chou, Yuanxiang Wang
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Publication number: 20190292218Abstract: In one aspect, the invention relates to compositions comprising stapled peptides, methods of making same, pharmaceutical compositions comprising same, and methods of treating various diseases, including, but not limited to, metabolic disorders such as diabetes, and cancers. The disclosed compounds comprise stapled peptides, including, but not limited to, stapled glucagon, axin, and p53 peptide homologues, which are useful as therapeutic agents for a variety of diseases as disclosed herein. The disclosed methods are useful in the preparation of a variety of stapled peptides, including stapled peptide homologues of glucagon, axin, and p53. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: July 17, 2017Publication date: September 26, 2019Inventors: Danny Hung-Chieh Chou, Yuanxiang Wang
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Publication number: 20190241640Abstract: The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.Type: ApplicationFiled: July 21, 2017Publication date: August 8, 2019Inventors: John Gerbrandt Tasman MENTING, Brian SMITH, Danny Hung-Chieh CHOU, Helena SAFAVI-HEMAMI, Michael Colin LAWRENCE, Olivera M. BALDOMERO
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Publication number: 20190092810Abstract: In one aspect, the invention relates to compositions comprising stapled peptides, methods of making same, pharmaceutical compositions comprising same, and methods of treating various diseases, including, but not limited to, metabolic disorders such as diabetes, and cancers. The disclosed compounds comprise stapled peptides, including, but not limited to, stapled glucagon, axin, and p53 peptide homologues, which are useful as therapeutic agents for a variety of diseases as disclosed herein. The disclosed methods are useful in the preparation of a variety of stapled peptides, including stapled peptide homologues of glucagon, axin, and p53. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: June 22, 2016Publication date: March 28, 2019Inventors: Danny Hung-Chieh Chou, Yuanxiang Wang
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Patent number: 9867869Abstract: Compounds, compositions, and methods for “smart” delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.Type: GrantFiled: December 12, 2013Date of Patent: January 16, 2018Assignees: Massachusetts Institute of Technology, The Children's Medical Center CorporationInventors: Daniel G. Anderson, Hung-Chieh Chou, Michael J. Webber, Benjamin C. Tang, Yair Levi, Yunlong Zhang, Rosemary Lynn Kanasty, Arturo Jose Vegas, Robert S. Langer
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Publication number: 20150320837Abstract: Compounds, compositions, and methods for “smart” delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.Type: ApplicationFiled: December 12, 2013Publication date: November 12, 2015Inventors: Daniel G. Anderson, Hung-Chieh Chou, Matthew J. Webber, Benjamin C. Tang, Yair Levi, Yunlong Zhang, Rosemary Lynn Kanasty, Arturo Jose Vegas, Robert A. Langer
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Patent number: 8741905Abstract: The invention relates to a compound of Formula I:Type: GrantFiled: May 6, 2013Date of Patent: June 3, 2014Assignees: The Broad Institute, Inc., President and Fellows of Harvard CollegeInventors: Bridget Wagner, Jeremy Duvall, Danny Hung-Chieh Chou