Patents by Inventor Hung-Chieh Chou

Hung-Chieh Chou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250038073
    Abstract: A package structure and a method for forming the same are provided. The package structure includes a first package structure and a second package structure. The first package structure includes a first device formed over a first substrate. The first device includes a first conductive plug connected to a through substrate via (TSV) structure formed in the first substrate. A buffer layer surrounds the first substrate. A first bonding layer is formed over the first substrate and the buffer layer. The second package structure includes a second device formed over a second substrate. A second bonding layer is formed over the second device. A hybrid bonding structure is between the first package structure and the second package structure by bonding the first bonding layer to the second bonding layer.
    Type: Application
    Filed: July 27, 2023
    Publication date: January 30, 2025
    Applicant: Taiwan Semiconductor Manufacturing Company, Ltd.
    Inventors: Ke-Han SHEN, Chih-Yuan CHEN, Jiung WU, Hung-Yi Kuo, Chung-Ju LEE, Tung-He CHOU, Ji CUI, Kuo-Chung YEE, Chen-Hua YU, Cheng-Chieh HSIEH, Yu-Jen LIEN, Yian-Liang KUO, Shih-Hao TSENG, Jen Yu WANG, Tzu-Chieh Chou
  • Publication number: 20230391838
    Abstract: ?-RgIA4 peptide analogs, compositions therewith, and methods for their treatment and use are disclosed and described. For example, an ?-RgIA4 peptide analog can comprise a recognition finger region configured to bind to an ?9?10 nicotinic acetylcholine receptor, and a side chain bonding configuration that protects an inter-cysteine sulfur linkage.
    Type: Application
    Filed: June 3, 2021
    Publication date: December 7, 2023
    Inventors: Joseph Michael McIntosh, Nan Zheng, Hung-Chieh Chou
  • Publication number: 20230381329
    Abstract: Disclosed herein, are Zwitterion polymer conjugates. The conjugate comprises a Zwitterion polymer, a linker, and a therapeutic polypeptide. Also described herein, are compositions comprising the conjugates, methods of their preparation, methods of treating diseases with the conjugates or their compositions, and method of preventing aggregation of therapeutic proteins.
    Type: Application
    Filed: May 26, 2023
    Publication date: November 30, 2023
    Inventors: Jessica Kramer, Danny Hung-Chieh Chou
  • Publication number: 20220389073
    Abstract: Disclosed are peptides comprising an insulin A chain peptide and an insulin B chain peptide, wherein the B chain peptide comprises a substitution at amino acid 10 and amino acid 20. Disclosed are methods of increasing insulin receptor activation in a subject comprising administering a therapeutically effective amount of a disclosed peptide. Disclosed are methods of lowering the blood sugar in a subject comprising administering a therapeutically effective amount of a disclosed peptide. Disclosed are methods of treating type 1 diabetes in a subject comprising administering a therapeutically effective amount of a disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: October 23, 2020
    Publication date: December 8, 2022
    Inventors: Danny Hung-Chieh Chou, Helena Safavi-Hemami
  • Publication number: 20220340636
    Abstract: The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.
    Type: Application
    Filed: January 4, 2022
    Publication date: October 27, 2022
    Inventors: John Gerbrandt Tasman MENTING, Brian SMITH, Danny Hung-Chieh CHOU, Helena SAFAVI-HEMAMI, Michael Colin LAWRENCE, Baldomero M. OLIVERA
  • Patent number: 11248034
    Abstract: The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: February 15, 2022
    Assignees: University of Utah Research Foundation, The Walter and Eliza Hall Institute of Medical Research
    Inventors: John Gerbrandt Tasman Menting, Brian Smith, Danny Hung-Chieh Chou, Helena Safavi-Hemami, Michael Colin Lawrence, Baldomero M. Olivera
  • Patent number: 11155577
    Abstract: In one aspect, the invention relates to compositions comprising stapled peptides, methods of making same, pharmaceutical compositions comprising same, and methods of treating various diseases, including, but not limited to, metabolic disorders such as diabetes, and cancers. The disclosed compounds comprise stapled peptides, including, but not limited to, stapled glucagon, axin, and p53 peptide homologues, which are useful as therapeutic agents for a variety of diseases as disclosed herein. The disclosed methods are useful in the preparation of a variety of stapled peptides, including stapled peptide homologues of glucagon, axin, and p53. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: October 26, 2021
    Assignee: University of Utah Research Foundation
    Inventors: Danny Hung-Chieh Chou, Yuanxiang Wang
  • Publication number: 20210214412
    Abstract: The present disclosure is concerned with insulin-based peptides, methods of making the peptides, and methods of treating diabetes using these peptides. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: April 15, 2019
    Publication date: July 15, 2021
    Inventor: Danny Hung-Chieh Chou
  • Patent number: 11034720
    Abstract: In one aspect, the invention relates to compositions comprising stapled peptides, methods of making same, pharmaceutical compositions comprising same, and methods of treating various diseases, including, but not limited to, metabolic disorders such as diabetes, and cancers. The disclosed compounds comprise stapled peptides, including, but not limited to, stapled glucagon, axin, and p53 peptide homologues, which are useful as therapeutic agents for a variety of diseases as disclosed herein. The disclosed methods are useful in the preparation of a variety of stapled peptides, including stapled peptide homologues of glucagon, axin, and p53. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: June 15, 2021
    Assignee: University of Utah Research Foundation
    Inventors: Danny Hung-Chieh Chou, Yuanxiang Wang
  • Publication number: 20190292218
    Abstract: In one aspect, the invention relates to compositions comprising stapled peptides, methods of making same, pharmaceutical compositions comprising same, and methods of treating various diseases, including, but not limited to, metabolic disorders such as diabetes, and cancers. The disclosed compounds comprise stapled peptides, including, but not limited to, stapled glucagon, axin, and p53 peptide homologues, which are useful as therapeutic agents for a variety of diseases as disclosed herein. The disclosed methods are useful in the preparation of a variety of stapled peptides, including stapled peptide homologues of glucagon, axin, and p53. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: July 17, 2017
    Publication date: September 26, 2019
    Inventors: Danny Hung-Chieh Chou, Yuanxiang Wang
  • Publication number: 20190241640
    Abstract: The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.
    Type: Application
    Filed: July 21, 2017
    Publication date: August 8, 2019
    Inventors: John Gerbrandt Tasman MENTING, Brian SMITH, Danny Hung-Chieh CHOU, Helena SAFAVI-HEMAMI, Michael Colin LAWRENCE, Olivera M. BALDOMERO
  • Publication number: 20190092810
    Abstract: In one aspect, the invention relates to compositions comprising stapled peptides, methods of making same, pharmaceutical compositions comprising same, and methods of treating various diseases, including, but not limited to, metabolic disorders such as diabetes, and cancers. The disclosed compounds comprise stapled peptides, including, but not limited to, stapled glucagon, axin, and p53 peptide homologues, which are useful as therapeutic agents for a variety of diseases as disclosed herein. The disclosed methods are useful in the preparation of a variety of stapled peptides, including stapled peptide homologues of glucagon, axin, and p53. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: June 22, 2016
    Publication date: March 28, 2019
    Inventors: Danny Hung-Chieh Chou, Yuanxiang Wang
  • Patent number: 9867869
    Abstract: Compounds, compositions, and methods for “smart” delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: January 16, 2018
    Assignees: Massachusetts Institute of Technology, The Children's Medical Center Corporation
    Inventors: Daniel G. Anderson, Hung-Chieh Chou, Michael J. Webber, Benjamin C. Tang, Yair Levi, Yunlong Zhang, Rosemary Lynn Kanasty, Arturo Jose Vegas, Robert S. Langer
  • Publication number: 20150320837
    Abstract: Compounds, compositions, and methods for “smart” delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.
    Type: Application
    Filed: December 12, 2013
    Publication date: November 12, 2015
    Inventors: Daniel G. Anderson, Hung-Chieh Chou, Matthew J. Webber, Benjamin C. Tang, Yair Levi, Yunlong Zhang, Rosemary Lynn Kanasty, Arturo Jose Vegas, Robert A. Langer
  • Patent number: 8741905
    Abstract: The invention relates to a compound of Formula I:
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: June 3, 2014
    Assignees: The Broad Institute, Inc., President and Fellows of Harvard College
    Inventors: Bridget Wagner, Jeremy Duvall, Danny Hung-Chieh Chou