Patents by Inventor Hussain Mansur Ghawas

Hussain Mansur Ghawas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9822128
    Abstract: The substituted spirooxindoles are MDM2-p53 inhibitors bearing a benzylidine (styryl) arm and have a complex fused ring system ideally suited for binding to the MDM2 protein, thereby interrupting its protein-protein interaction (PPI). Sixteen compounds, designated 4a-4p, were synthesized in a simple smooth method using an asymmetric 1,3-dipolar reaction as the key step. Testing showed that the compounds exhibit anti-cancer activity against various forms of cancer cells affecting humans.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: November 21, 2017
    Inventors: Assem Barakat, Mohammad Shahidul Islam, Abdullah Mohammed Al Majid, Hussain Mansur Ghawas, Fardous F. El-Senduny, Farid A. Badria, Yaseen Ali Mosa Mohamed Elshaier, Hazem A. Ghabbour