Patents by Inventor Huw M. Nash

Huw M. Nash has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20130072439
    Abstract: Disclosed are peptidomimetic macrocycles comprising a helix, such as an alpha helix, and methods of using such macrocycles for the treatment of disease such as cancer. In other aspects, the peptidomimetic macrocycle comprises an a,a-disubstituted amino acid, or may comprise a crosslinker linking the a-positions of at least two amino acids or at least one of said two amino acids may be an a,a-disubstituted amino acid. Further included is the targeting of components of the Wnt signaling pathway such as the Tcf4-/3-catenin complex.
    Type: Application
    Filed: September 22, 2010
    Publication date: March 21, 2013
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Jia-wen Han, Tomi K. Sawyer, Justin Noehre, Noriyuki Kawahata
  • Peptidomimetic macrocycles
    Patent number: 8399405
    Abstract: Biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides; and methods of making and identifying such improved polypeptides.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: March 19, 2013
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20130023646
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: August 8, 2012
    Publication date: January 24, 2013
    Applicant: AILERON THERAPEUTICS, INC.
    Inventors: Huw M. NASH, Rosana KAPELLER-LIBERMANN, Tomi K. SAWYER, Noriyuki KAWAHATA, Vincent GUERLAVAIS, Matthew IADANZA
  • METHODS FOR PREPARING PURIFIED POLYPEPTIDE COMPOSITIONS
    Publication number: 20120264674
    Abstract: The present invention relates to purified peptidomimetic macrocycles. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: January 13, 2012
    Publication date: October 18, 2012
    Applicant: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, Matthew Iadanza, Christopher Leitheiser, Noriyuki Kawahata
  • TRIAZOLE MACROCYCLE SYSTEMS
    Publication number: 20120190818
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production.
    Type: Application
    Filed: February 9, 2012
    Publication date: July 26, 2012
    Applicant: Aileron Therapeutics, Inc.
    Inventor: Huw M. Nash
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120178700
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: September 22, 2009
    Publication date: July 12, 2012
    Applicant: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Jiawen Han, Tomi K. Sawyer, Justin Noehre
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120172311
    Abstract: The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides.
    Type: Application
    Filed: February 3, 2012
    Publication date: July 5, 2012
    Applicant: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • THERAPEUTIC PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120149648
    Abstract: The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
    Type: Application
    Filed: January 17, 2012
    Publication date: June 14, 2012
    Applicant: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Jiawen Han
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120115793
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: September 22, 2009
    Publication date: May 10, 2012
    Applicant: Alleron Therapeutics, Inc
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Jiawen Han, Tomi K. Sawyer, Justin Noehre
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120115783
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: September 22, 2009
    Publication date: May 10, 2012
    Applicant: Alleron therapeutics, Inc
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Jiawen Han, Tomi K. Sawyer, Justin Noehre
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120101047
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: September 22, 2009
    Publication date: April 26, 2012
    Applicant: Aileron Therapetics Inc.
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Jiawen Han, Tomi K. Sawyer, Justin Noehre
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120040889
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of viral disease.
    Type: Application
    Filed: January 14, 2010
    Publication date: February 16, 2012
    Applicant: Aileron Therapeutics Inc.
    Inventors: Huw M. Nash, David Allen Annis
  • TRIAZOLE MACROCYCLE SYSTEMS
    Publication number: 20110263815
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production.
    Type: Application
    Filed: April 29, 2011
    Publication date: October 27, 2011
    Applicant: Aileron Therapeutics, Inc., a Delaware Corporation
    Inventor: Huw M. Nash
  • COMPOSITIONS AND METHODS FOR ENHANCING CELLULAR TRANSPORT OF BIOMOLECULES
    Publication number: 20110250685
    Abstract: The present invention discloses compositions and methods for delivery of biomolecules into cells. Compositions comprise peptidomimetic macrocycles complexed or conjugated to biomolecules such as nucleic acids.
    Type: Application
    Filed: June 3, 2009
    Publication date: October 13, 2011
    Inventor: Huw M. Nash
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20110223149
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties, such as protease resistance, relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: October 14, 2010
    Publication date: September 15, 2011
    Applicant: AILERON THERAPEUTICS, INC.
    Inventors: Huw M. NASH, David Allen ANNIS, Vincent GUERLAVAIS, Lawrence LICKLIDER
  • Bis-sulfhydryl macrocyclization systems
    Patent number: 7981998
    Abstract: Peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production, are provided.
    Type: Grant
    Filed: June 16, 2008
    Date of Patent: July 19, 2011
    Assignee: Aileron Therapeutics, Inc.
    Inventor: Huw M. Nash
  • Triazole macrocycle systems
    Patent number: 7981999
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production. In various embodiments, the peptidomimetic macrocycles are of Formula I: The linker L includes a triazole moiety. Peptidomimetic macrocycles according to the invention may exhibit increased ?-helical or beta sheet structure in aqueous solution compared to a corresponding non-macrocyclic polypeptide.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: July 19, 2011
    Assignee: Aileron Therapeutics, Inc.
    Inventor: Huw M. Nash
  • Biologically Active Peptidomimetic Macrocycles
    Publication number: 20110144303
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: October 13, 2009
    Publication date: June 16, 2011
    Applicant: AILERON Therapeutics, Inc.
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Vincent Guerlavais, Matthew Iadanza
  • Bis-sulfhydryl macrocyclization systems
    Patent number: 7960506
    Abstract: Peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production, are provided.
    Type: Grant
    Filed: December 14, 2007
    Date of Patent: June 14, 2011
    Assignee: Aileron Therapeutics, Inc.
    Inventor: Huw M. Nash
  • PEPTIDOMIMETIC MACROCYCLES WITH IMPROVED PROPERTIES
    Publication number: 20100298201
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: November 24, 2009
    Publication date: November 25, 2010
    Applicant: AILERON Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata