Patents by Inventor Hwei-Ru Tsou

Hwei-Ru Tsou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein tyrosine kinase enzyme inhibitors
    Patent number: 7982043
    Abstract: This invention provides compounds of formula 1, having the structure wherein R1, R2, R3, R4, and R5 are described within the specification.
    Type: Grant
    Filed: June 10, 2008
    Date of Patent: July 19, 2011
    Assignee: Wyeth LLC
    Inventors: Allan Wissner, Sridhar Krishna Rabindran, Hwei-Ru Tsou
  • Substituted isoquinoline-1,3(2,4)-diones, 1-thioxo,1,4-dihydro-2-isoquinoline-3-ones and 1,4-dihyro-3 (2)-isoquinolones and methods of use thereof
    Patent number: 7713994
    Abstract: This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L1, Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: May 11, 2010
    Assignee: Wyeth LLC
    Inventors: Hwei-Ru Tsou, Semiramis Ayral-Kaloustian, Gary Harold Birnberg, Middleton Brawner Floyd, Joshua Kaplan, Kristina M. Kutterer, Xiaoxiang Liu, Ramaswamy Nilakantan, Mercy Adufa Otteng, Zhilian Tang, Arie Zask, Tritin Tran, Scott Christian Mayer, Annette L. Banker, Marvin Reich
  • 4-ARYLOXYQUINOLIN-2(1H)-ONES AS MTOR KINASE AND PI3 KINASE INHIBITORS, FOR USE AS ANTI-CANCER AGENTS
    Publication number: 20100068204
    Abstract: Compounds of the formula I and pharmaceutically acceptable salts thereof, wherein A, B, R1, R2, R3, R4, R5, R6, and R7 are defined as set forth herein are disclosed. Also disclosed are pharmaceutical compositions comprising the compounds of the invention and a pharmaceutically acceptable carrier, methods of making the compounds of the invention and methods of using the compounds for inhibiting mTOR and PI3 kinases and for treating cancers.
    Type: Application
    Filed: September 14, 2009
    Publication date: March 18, 2010
    Applicant: Wyeth
    Inventors: Hwei-Ru Tsou, Gary Harold Birnberg, Gloria Jean MacEwan, Mercy Adufa Otteng, Pawel Wojciech Nowak, Semiramis Ayral-Kaloustian, Tarek Suhayl Mansour, Arie Zask, Ker Yu
  • 3-SUBSTITUTED-1H-INDOLE, 3-SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE AND 3-SUBSTITUTED-1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES
    Publication number: 20100061982
    Abstract: The invention relates to 3-substituted-1H-indole, 3-substituted-1H-pyrrolo[2,3-b]pyridine, and 3-substituted-1H-pyrrolo[3,2-b]pyridine compounds of the Formula 1: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
    Type: Application
    Filed: September 10, 2009
    Publication date: March 11, 2010
    Applicant: Wyeth
    Inventors: Semiramis Ayral-Kaloustian, Tarek Suhayl Mansour, Hwei-Ru Tsou, Nan Zhang, Aranapakam Mudumbai Venkatesan, Li Di, Edward Harvel Kerns
  • 3-SUBSTITUTED-1H-INDOLE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES
    Publication number: 20090311217
    Abstract: The invention relates to 3-substituted-1H-indole compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
    Type: Application
    Filed: May 28, 2009
    Publication date: December 17, 2009
    Applicant: Wyeth
    Inventors: Matthew Gregory Bursavich, Nan Zhang, Semiramis Ayral-Kaloustian, James Thomas Anderson, Thai Hiep Nguyen, Sabrina Lombardi, David Malwitz, Natasja Brooijmans, Derek Cecil Cole, Adam Matthew Gilbert, Pawel Wojciech Nowak, Kaapjoo Park, Sasmita Das, Hwei-Ru Tsou, Aranapakam Mudumbai Venkatesan, Mercy Adufa Otteng, Gary Harold Birnberg, Gloria Jean MacEwan
  • 3-SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE AND 3-SUBSTITUTED-1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES
    Publication number: 20090298820
    Abstract: The invention relates to 3-substituted-1H-pyrrolo[2,3-b]pyridine, and 3-substituted-1H-pyrrolo[3,2-b]pyridine compounds of the Formula 1: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
    Type: Application
    Filed: May 28, 2009
    Publication date: December 3, 2009
    Applicant: Wyeth
    Inventors: Hwei-Ru Tsou, Gary Harold Birnberg, Gloria Jean MacEwan, Semiramis Ayral-Kaloustian, Matthew Gregory Bursavich, Sabrina Lombardi, Nan Zhang, Adam Matthew Gilbert, George Theordore Grosu, Natasja Brooijmans, Thai Hiep Nguyen
  • 2-Aryl- and 2-Heteroarylthiazolyl Compounds, Methods for Their Preparation and Use Thereof
    Publication number: 20090270363
    Abstract: The present invention discloses fused bicyclic 2-aryl- or 2-heteroarylthiazolyl compounds and their pharmaceutically acceptable salts and esters thereof, which are useful for inhibiting the growth of cancerous cells, inhibiting human breast carcinoma tumor growth in particular and to treat diseases or disorders associated with securin, including elevated securin levels.
    Type: Application
    Filed: March 27, 2009
    Publication date: October 29, 2009
    Applicant: Wyeth
    Inventors: Nan Zhang, Semiramis Ayral-Kaloustian, Tarek Suhayl Mansour, Thai Hiep Nguyen, Chuansheng Niu, Edward Christian Rosfjord, Ronald Suayan, Hwei-Ru Tsou
  • PROTEIN TYROSINE KINASE ENZYME INHIBITORS
    Publication number: 20080319011
    Abstract: This invention provides compounds of formula 1, having the structure wherein R1, R2, R3, R4, and R5 are described within the specification.
    Type: Application
    Filed: June 10, 2008
    Publication date: December 25, 2008
    Applicant: Wyeth
    Inventors: Allan Wissner, Sridhar Krishna Rabindran, Hwei-Ru Tsou
  • Protein tyrosine kinase enzyme inhibitors
    Patent number: 7399865
    Abstract: This invention provides compounds of formula 1, having the structure wherein R1, R2, R3, R4, and R5 are described within the specification.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: July 15, 2008
    Assignee: Wyeth
    Inventors: Allan Wissner, Sridhar Krishna Rabindran, Hwei-Ru Tsou
  • Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3 (2H)-isoquinolones and methods of use thereof
    Publication number: 20080085890
    Abstract: This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L1, Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.
    Type: Application
    Filed: March 26, 2007
    Publication date: April 10, 2008
    Applicant: Wyeth
    Inventors: Hwei-Ru Tsou, Semiramis Ayral-Kaloustian, Gary Birnberg, Middleton Floyd, Joshua Kaplan, Kristina Kutterer, Xiaoxiang Liu, Ramaswamy Nilakantan, Mercy Otteng, Zhilian Tang, Arie Zask, Tritin Tran, Scott Mayer, Annette Banker, Marvin Reich
  • Tricyclic protein kinase inhibitors
    Publication number: 20060247217
    Abstract: This invention provides compounds of formula 1, having the structure which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.
    Type: Application
    Filed: June 29, 2006
    Publication date: November 2, 2006
    Inventors: Dan Berger, Minu Dutia, Frenel DeMorin, Diane Boschelli, Dennis Powell, Hwei-Ru Tsou, Allan Wissner, Nan Zhang, Fei Ye, Biqi Wu
  • Tricyclic protein kinase inhibitors
    Patent number: 7105531
    Abstract: This invention provides compounds of formula 1, having the structure which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: September 12, 2006
    Assignee: WYETH
    Inventors: Dan M. Berger, Minu D. Dutia, Frenel F. DeMorin, Diane H. Boschelli, Dennis W. Powell, Hwei-Ru Tsou, Allan Wissner, Nan Zhang, Fei Ye, Biqi Wu
  • Substituted pyrazolo[1,5-a] pyrimidines and process for making same
    Publication number: 20060063785
    Abstract: This invention relates to novel pyrazolo[1,5-a]pyrimidine compounds and the therapeutically acceptable salts thereof. These compounds are useful as anti-proliferative agents in mammals, including humans.
    Type: Application
    Filed: September 9, 2005
    Publication date: March 23, 2006
    Inventors: Yanong Wang, Ariamala Gopalsamy, Dennis Powell, Hwei-Ru Tsou, Nan Zhang
  • Method of using substituted pyrazolo [1,5-a] pyrimidines
    Publication number: 20060063784
    Abstract: This invention relates to novel methods of use of certain pyrazolo[1,5-a]pyrimidine compounds and the therapeutically acceptable salts thereof. This invention also relates to novel methods of using these compounds as anti-proliferative agents in mammals, including humans.
    Type: Application
    Filed: September 9, 2005
    Publication date: March 23, 2006
    Inventors: Yanong Wang, Ariamala Gopalsamy, Erick Honores, Lee Jennings, Steven Johnson, Dennis Powell, Fuk-Wah Sum, Hwei-Ru Tsou, Biqi Wu, Nan Zhang
  • Protein tyrosine kinase enzyme inhibitors
    Publication number: 20050059678
    Abstract: This invention provides compounds of formula 1, having the structure wherein R1, R2, R3, R4, and R5 are described within the specification.
    Type: Application
    Filed: September 10, 2004
    Publication date: March 17, 2005
    Applicant: Wyeth
    Inventors: Allan Wissner, Sridhar Rabindran, Hwei-Ru Tsou
  • 3-cyanoquinolines as inhibitors of EGF-R and HER2 kinases
    Patent number: 6821988
    Abstract: This invention provides compounds of Formula (I), represented by the structure wherein G1, G2, G3, G4, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: November 23, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Allan Wissner, Hwei-Ru Tsou, Middleton Brawner Floyd, Jr., Bernard D. Johnson, Elsebe Geraldine Overbeek-Klumpers
  • 3-Cyanoquinolines,3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
    Publication number: 20040176602
    Abstract: This invention provides compounds of Formula (I), having the structure 1
    Type: Application
    Filed: January 9, 2004
    Publication date: September 9, 2004
    Applicant: Wyeth
    Inventors: Diane Harris Boschelli, Yanong Wang, Frank Charles Boschelli, Dan Maarten Berger, Nan Zhang, Dennis William Powell, Fei Ye, Ayako Yamashita, Frenel Fils DeMorin, Biqi Wu, Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
  • Tricyclic protein kinase inhibitors
    Publication number: 20040110762
    Abstract: This invention provides compounds of formula 1, having the structure 1
    Type: Application
    Filed: July 10, 2003
    Publication date: June 10, 2004
    Applicant: WYETH
    Inventors: Dan M. Berger, Minu D. Dutia, Frenel F. DeMorin, Diane H. Boschelli, Dennis W. Powell, Hwei-Ru Tsou, Allan Wissner, Nan Zhang, Fei Ye, Biqi Wu
  • 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
    Patent number: 6689772
    Abstract: This invention provides compounds of Formula (I), having the structure where T, Z, X, A, R1, R2a, R2b, R2c, R3, R4, and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: February 10, 2004
    Assignee: Wyeth
    Inventors: Diane Harris Boschelli, Yanong Wang, Frank Charles Boschelli, Dan Maarten Berger, Nan Zhang, Dennis William Powell, Fei Ye, Ayako Yamashita, Frenel Fils DeMorin, Biqi Wu, Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
  • Substituted 3-cyanoquinolines
    Patent number: RE42376
    Abstract: This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: May 17, 2011
    Assignee: Wyeth Holdings Corporation
    Inventors: Allan Wissner, Hwei-Ru Tsou, Dan M. Berger, Middleton B. Floyd, Jr., Philip R. Hamann, Nan Zhang, Philip Frost