Patent number: 10590078
Abstract: The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav1.7, a preparation method thereof and use thereof. The compound represented by the Formula 1 or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof can be effectively used in the prevention or treatment of pains, for example, acute pain, chronic pain, pain from nervous disease, postoperative pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, paroxysmal extreme pain disorder (PEPD).
Type:
Grant
Filed:
February 11, 2016
Date of Patent:
March 17, 2020
Assignee:
Daewoong Pharmaceutical Co., Ltd.
Inventors:
Ji Duck Kim, Hyung Geun Lee, Inwoo Kim, Sun Ah Jun, Myunggi Jung, Hyo Shin Kim
Patent number: 9376429
Abstract: The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav1.7, a preparation method thereof and the use thereof. A compound represented by formula 1 according to the invention, or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof may be effectively used for the prevention or treatment of pain, for example, acute pain, chronic pain, neuropathic pain, post-surgery pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, or paroxysmal extreme pain disorder (PEPD).
Type:
Grant
Filed:
October 15, 2013
Date of Patent:
June 28, 2016
Assignee:
Daewoong Pharmaceutical Co., Ltd.
Inventors:
Ha Young Kim, In Woo Kim, Sun Ah Jun, Yun Soo Na, Hyung Geun Lee, Min Jae Cho, Jun Hee Lee, Hyo Shin Kim, Yun Soo Yoon, Kyung Ha Chung, Ji Duck Kim
Publication number: 20150336944
Abstract: The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav1.7, a preparation method thereof and the use thereof. A compound represented by formula 1 according to the invention, or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof may be effectively used for the prevention or treatment of pain, for example, acute pain, chronic pain, neuropathic pain, post-surgery pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, or paroxysmal extreme pain disorder (PEPD).
Type:
Application
Filed:
October 15, 2013
Publication date:
November 26, 2015
Inventors:
Ha Young Kim, In Woo Kim, Sun Ah Jun, Yun Soo Na, Hyung Geun Lee, Min Jae Cho, Jun Hee Lee, Hyo Shin Kim, Yun Soo Yoon, Kyung Ha Chung, Ji Duck Kim