Abstract: A domain adaptation device for longitudinal data includes a first module that generates first transformation data using a projection matrix for domain transformation and a graph matrix for data filtering, a second module that determines a domain of the first transformation data, and a third module that determines a label of the first transformation data.

Abstract: A prospective classification device for predicting dementia that predicts a risk of a patient with mild cognitive impairment being converted to a dementia patient based on the characteristics of prognostic brain imaging data converted from a diagnostic brain imaging data and a method of operating the same are disclosed. The prospective classification device is configured to convert features of the diagnostic brain imaging data obtained at the time of diagnosis of a patient with mild cognitive impairment into features of prognostic brain imaging data corresponding to the prognostic time after the time of diagnosis using a prospective classification model.

Abstract: Disclosed is a learning method and device for alzheimer prediction model based on domain adaptation performed by at least one processor including extracting a point related to an object in a learning image from the learning image for a 3D reconstruction model, obtaining a gradient map including surrounding context information in three dimensions of the point from a 3D model of the object, determining a weight of the point based on the learning image and the gradient map, and learning the 3D reconstruction model by using the weight such that the 3D model of the object is output from the 3D reconstruction model into which the learning image is input.