Abstract: The present invention pertains to cannabinoid (CB) receptor inverse agonists and neutral antagonists, and especially CB1 and CB2 inverse agonists and neutral antagonists; such as, for example, certain pyrazole compounds; their use in the inhibition of osteoclasts (for example, the inhibition of the survival, formation, and/or activity of osteoclasts), and/or in the inhibition of bone resorption; their use in connection with treatment of bone disorders, such as conditions mediated by osteoclasts (e.g., increased osteoclast activity) and/or characterised by (e.g., increased) bone resorption, such as osteoporosis (e.g., osteoporosis not associated with inflammation; e.g., osteoporosis associated with a genetic predisposition, sex hormone deficiency, or ageing), cancer associated bone disease, and Paget's disease of bone.

Abstract: A unit price setting arrangement for differently priced products available from a remotely located dispenser for example, grades of fuel, from a pump, consists of a central transmitter and a receiver in each dispenser. The transmitter forms a series of fixed length binary words, one for each product, and transmits them in sequence repetitively. Each receiver counts words of the sequence received and compares them with the position of a selected product in the sequence to determine which word relates to the product of interest. That word only is used and is applied to a comparator with a corresponding word stored from a previous transmission to detect a change in the word. A shift register having a stored bit responds to an unsuccessful comparison to shift the bit through one location and a shift through a predetermined number of locations by successive unsuccessful comparisons, if the change is permanent, causes a controller to replace the stored value with the newly received one.