Patents by Inventor Ian G. Fotheringham

Ian G. Fotheringham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6197558
    Abstract: A process for making natural and unnatural amino acids which comprises reacting a first amino acid, a keto acid and a transaminase enzyme under conditions appropriate to produce a second amino acid and pyruvate; reacting the pyruvate with acetolactate synthase under conditions appropriate to produce a compound that does not react with the transaminase enzyme and separating the second amino acid.
    Type: Grant
    Filed: May 19, 1997
    Date of Patent: March 6, 2001
    Assignee: NSC Technologies
    Inventor: Ian G. Fotheringham
  • Patent number: 5834259
    Abstract: A process and composition for preparing D-aspartic acid and .beta.-alanine from D,L-aspartic acid, wherein a solution of D,L-aspartic acid or a salt thereof is contacted with a composition having an L-aspartate-.alpha.-decarboxylase activity of greater than 100 .mu.mol L-aspartate used per hour per gram of cells, under appropriate conditions to produce D-aspartic acid and .beta.-alanine.
    Type: Grant
    Filed: October 28, 1996
    Date of Patent: November 10, 1998
    Assignee: Monsanto Company
    Inventors: David P. Pantaleone, Ian G. Fotheringham, Jennifer L. Ton
  • Patent number: 5728555
    Abstract: The present invention relates to materials and methods for production of natural and unnatural D-amino acids. In particular, the present invention relates to a fermentation method for the production of D-amino acids using recombinant host cells.Specifically, the invention relates to a method for producing a D-amino acid in a cell, comprising:(a) incorporating into the cell a D-aminotransferase gene and a L-aminodeaminase gene;(b) culturing the cell in a cell culture medium; and(c) isolating the D-amino acid from the cell culture medium.The invention also relates to a method for producing D-phenylalanine in a cell, comprising:(a) incorporating into the cell a D-aminotransferase gene, a L-aminodeaminase gene and means for increasing production of phenylpyruvate;(b) culturing the cell in a cell culture medium; and(c) isolating the D-phenylalanine from the cell culture medium.The invention also relates to the preparation of recombinant cells for use in the production of enantiomerically pure D-amino acids.
    Type: Grant
    Filed: September 30, 1996
    Date of Patent: March 17, 1998
    Assignee: Monsanto Company
    Inventors: Ian G. Fotheringham, Paul P. Taylor, Jennifer L. Ton
  • Patent number: 5316943
    Abstract: Recombinant cells and an improved method utilizing them is disclosed for the preparation of an optically pure, L-amino acid from its D and D,L isomer forms. The process utilizes cell cultures that possess high aminotransferase activity that exhibits moderate selectivity in the conversion of D and L amino acids to their respective 2-keto acids as well as absolute stereospecificity in the conversion of the 2-keto acids to the L isomer alone.
    Type: Grant
    Filed: June 19, 1989
    Date of Patent: May 31, 1994
    Inventors: Gene E. Kidman, Larry E. Robinson, Mark P. Scollar, Ian G. Fotheringham
  • Patent number: 5120837
    Abstract: Disclosed are DNA sequences bonding deletion, substitution and/or addition analogs of the E. coli enzyme, chorismate mutase/prephenate dehydratase (CMPD). Preferred expression products include [des-Gln.sup.307, des-Ala.sup.308, des-Gly.sup.309, des-Ala.sup.310 ]CMPD; [Leu.sup.306 ]CMPD; [des-Thr.sup.304, Lys.sup.305, des-Gln.sup.306 ]CMPD; and [Cys.sup.309 ]CMPD display enzymatic activity of the wild type enzyme but are more resistant to inhibition in the presence of phenylalanine.
    Type: Grant
    Filed: September 20, 1989
    Date of Patent: June 9, 1992
    Assignee: The NutraSweet Company
    Inventors: Ian G. Fotheringham, Jennifer Nelms