Patents by Inventor Ichiro Shirahase

Ichiro Shirahase has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5086049
    Abstract: Quinolinecarboxylic acid derivatives of the formula (I) ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sup.1 is hydrogen, straight or branch chain lower alkyl or phenyl unsubstituted or substituted by one or more halo moieties; R.sup.2 is hydrogen or straight or branch chain lower alkyl; and R.sup.3 is hydrogen, halo or straight or branch chain lower alkoxy, are useful for treating bacterial infections in humans and animals.
    Type: Grant
    Filed: April 8, 1991
    Date of Patent: February 4, 1992
    Assignee: Nipponshinyaku Co., Ltd.
    Inventors: Masahiro Kise, Masahiko Kitano, Masakuni Ozaki, Kenji Kazuno, Masahito Matsuda, Ichiro Shirahase, Jun Segawa
  • Patent number: 5011831
    Abstract: Quinolinecarboxylic acid derivatives of the formula (I) ##STR1## and pharmaceutically acceptable salts thereof wherein R.sup.1 is hydrogen, straight or branch chain lower alkyl or phenyl unsubstituted or substituted by one or more halo moieties; R.sup.2 is hydrogen or straight or branch chain lower alkyl; and ##STR2## is a 5- or 6-membered ring wherein the nitrogen atom is the only heteroatom or where there is a second heteroatom selected from the group consisting of nitrogen, oxygen and sulfur, said 5- or 6-membered ring being unsubstituted or substituted by lower alkyl, amino or mono- or di-lower alkyl amino are useful for treating bacterial infections in humans and animals.
    Type: Grant
    Filed: November 7, 1988
    Date of Patent: April 30, 1991
    Assignee: Nippon Shinyaku Co. Ltd.
    Inventors: Masahiro Kise, Masahiko Kitano, Masakuni Ozaki, Kenji Kazuno, Masahito Matsuda, Ichiro Shirahase, Yoshifumi Tomii
  • Patent number: 4843070
    Abstract: Anti-bacterial and anti-fungal compounds of formula I and pharmaceutically acceptable salts thereof: ##STR1## in which R.sup.1 is hydrogen, alkyl or substituted or unsubstituted phenyl; R.sup.2 is hydrogen, alkyl, alkoxy, hydroxy, halgen, nitro or substituted or unsubstituted amino; R.sup.3 is hydrogen or substituted or unsubstituted alkyl; R.sup.4 and R.sup.5 are the same or different and are alkyl or hydroxyalkyl or R.sup.4 and R.sup.5 together with the nitrogen atom to which they are attached form an unsubstituted or substituted heterocyclic ring having the depicted nitrogen atom as the sole heteroatom or which may have nitrogen, oxygen or sulphur atoms as additional heteroatoms; and X is halogen.
    Type: Grant
    Filed: May 13, 1987
    Date of Patent: June 27, 1989
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Masahiro Kise, Masahiko Kitano, Masakuni Ozaki, Kenji Kazuno, Ichiro Shirahase, Yoshifumi Tomii, Jun Segawa
  • Patent number: 4594345
    Abstract: 3-methylflavone derivatives which are useful in the treatment of allergies, asthma and inflammation.
    Type: Grant
    Filed: June 24, 1983
    Date of Patent: June 10, 1986
    Assignee: Nippon Shinyaku Co. Ltd.
    Inventors: Hiroshi Enomoto, Tadatoshi Nomura, Yoshiaki Aoyagi, Shoichi Chokai, Masao Murase, Kichiro Inoue, Ichiro Shirahase
  • Patent number: 4533668
    Abstract: N-aralkylmoranoline and N-aralkenylmoranoline, and their pharmaceutical acceptable non-toxic acid addition salts thereof, pharmaceutical compositions containing the same and methods of inhibiting the increase in blood sugar level by administration of the same.
    Type: Grant
    Filed: April 27, 1979
    Date of Patent: August 6, 1985
    Assignee: Nippon Shinyaku Co. Ltd.
    Inventors: Shingo Matsumura, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoshiaki Yoshikuni, Kohei Kura, Masahiro Yagi, Ichiro Shirahase
  • Patent number: 4336373
    Abstract: Bis(2-hydroxymethyl-3,4,5-trihydroxypiperidine-1-yl-propenyl) compounds and their acid addition salts are antihyperglycemic agents. Typical examples are 1,4-bis[3-(2-hydroxymethyl-3,4,5-trihydroxypiperidin-1-yl)prop-2-enyl] benzene and 1,3-bis-{4-[3-(2-hydroxymethyl-3,4,5-trihydroxy-piperidin-1-yl)prop-2-enyl ]phenoxy}propane.
    Type: Grant
    Filed: March 26, 1981
    Date of Patent: June 22, 1982
    Assignee: Nippon Shinyaku Company, Ltd.
    Inventors: Shingo Matsumura, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoshiaki Yoshikuni, Masahiro Yagi, Kohei Kura, Ichiro Shirahase
  • Patent number: 4336374
    Abstract: 2-Hydroxymethyl-3,4,5-trihydroxypiperidines bearing a quaternary ammonium-substituted cinnamyl group on the piperidine nitrogen atom and their acid addition salts are antihyperglycemic agents. A typical example is 1-(4-trimethylammoniumcinnamyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine chloride.
    Type: Grant
    Filed: March 26, 1981
    Date of Patent: June 22, 1982
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Shingo Matsumura, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoshiaki Yoshikuni, Masahiro Yagi, Kohei Kura, Ichiro Shirahase
  • Patent number: 4182767
    Abstract: 2-Hydroxymethyl-3,4,5-trihydroxy-N-alkylpiperidines and their acid addition salts are antihyperglycemic agents. A typical example is 2-hydroxymethyl-3,4,5-trihydroxy-N-methylpiperidine.
    Type: Grant
    Filed: May 10, 1978
    Date of Patent: January 8, 1980
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Hiromu Murai, Hiroshi Enomoto, Yoshiaki Aoyagi, Yoshiaki Yoshikuni, Masahiro Yagi, Ichiro Shirahase