Patents by Inventor Igor Leonidovich Rodionov

Igor Leonidovich Rodionov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190195759
    Abstract: Methods of treating an inert surface of a substrate to improve the adherence to the treated surface of micro-dimensioned particles including the steps of: contacting the inert surface with in an aqueous dispersion of a construct of the structure F-S-L; and then washing the surface with an aqueous vehicle to provide the treated surface, where F is a polyamine; S is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is a diacyl- or dialkyl-glycerophospholipid.
    Type: Application
    Filed: February 25, 2019
    Publication date: June 27, 2019
    Inventors: Stephen Micheal HENRY, Stephen Robert PARKER, Nicolai Vladimirovich BOVIN, Igor Leonidovich RODIONOV
  • Publication number: 20180259513
    Abstract: A facile laboratory-based method and kit for use in accordance with the method is disclosed. The method allows for the localisation of biomolecules comprising a conjugatable sulfhydryl group to be localised to the surface of cells, such as red blood cells, as lipid conjugates. The method obviates the need to purify the lipid-conjugated biomolecule before contacting with the cells.
    Type: Application
    Filed: January 29, 2018
    Publication date: September 13, 2018
    Inventors: Nikolai Vladimirovich BOVIN, Stephen Micheal HENRY, Igor Leonidovich RODIONOV
  • Patent number: 10040823
    Abstract: Functional-lipid constructs of the structure F-S-L are disclosed, wherein F comprises a tyrosine or histidine residue, S is a spacer covalently linking F to L and L is a lipid. The functional residue may be iodinated and used to radiolabel a biological entity with 1251 and the iodinated constructs are used in a non-invasive method of monitoring the distribution of a biological entity in vivo.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: August 7, 2018
    Assignee: KODE BIOTECH LIMITED
    Inventors: Nikolai Vladimirovich Bovin, Stephen Henry, Elena Yurievna Korchagina, Igor Leonidovich Rodionov, Alexander Borisovich Tuzikov
  • Patent number: 9915653
    Abstract: Method of localizing a sulfhydryl (—SH) group containing biomolecule to the surface of a cell membrane by mixing in a volatile reaction buffer a molar excess of the sulfhydryl (—SH) group containing biomolecule with a lipid conjugated maleimide of the structure F-S-L as defined in the specification to provide a reaction mix, incubating the reaction mix for a time and at a temperature sufficient to allow all the lipid conjugated maleimide to have reacted with the sulfhydryl (—SH) group, and freeze-drying the reaction mix to remove the volatile reaction buffer and provide a reaction product. An aqueous solution of the reaction product is contacted with the cell membrane.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: March 13, 2018
    Inventors: Nikolai Vladimirovich Bovin, Stephen Michael Henry, Igor Leonidovich Rodionov
  • Patent number: 9821080
    Abstract: Non-invasive method of monitoring by radioactivity bioscanning the distribution of a biological entity in a subject in vivo by administering to the subject a radioiodinated form of the biological entity. The radioiodinated form is prepared by contacting an aqueous suspension of the biological entity with a radioiodinated construct of the structure F-S-L where F comprises a radioiodinated tyrosine moiety, S is a spacer covalently linking F to L, and L is a lipid.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: November 21, 2017
    Inventors: Nikolai Vladimirovich Bovin, Stephen Henry, Elena Yurievna Korchagina, Igor Leonidovich Rodionov, Alexander Borisovich Tuzikov
  • Publication number: 20170320914
    Abstract: Water dispersible, multivalent ligand-lipid constructs that spontaneously and stably incorporate into membranes are disclosed.
    Type: Application
    Filed: November 23, 2015
    Publication date: November 9, 2017
    Inventors: Nicolai Vladimirovich BOVIN, Stephen Micheal HENRY, Elena KORCHAGINA, Igor Leonidovich RODIONOV, Alexander Borisovich TUZIKOV
  • Patent number: 9802981
    Abstract: The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: October 31, 2017
    Assignee: Kode Biotech Limited
    Inventors: Nicolai Vladimirovich Bovin, Stephen Micheal Henry, Igor Leonidovich Rodionov, Cristina-Simona Weinberg, Alexander Borisovich Tuzikov
  • Publication number: 20170240597
    Abstract: Functional-lipid constructs of the structure F-S-L are disclosed, wherein F comprises a tyrosine or histidine residue, S is a spacer covalently linking F to L and L is a lipid. The functional residue may be iodinated and used to radiolabel a biological entity with 1251 and the iodinated constructs are used in a non-invasive method of monitoring the distribution of a biological entity in vivo.
    Type: Application
    Filed: April 18, 2017
    Publication date: August 24, 2017
    Inventors: Nikolai Vladimirovich Bovin, Stephen Henry, Elena Yurievna Korchagina, Igor Leonidovich Rodionov, Alexander Borisovich Tuzikov
  • Publication number: 20170231228
    Abstract: An antimicrobial surface treatment method comprising the step of contacting a stainless-steel surface with an aqueous dispersion of at least one functional-lipid construct where the lipid moiety is a phosphatidylethanolamine and the functional moiety confers the antimicrobial activity.
    Type: Application
    Filed: May 3, 2017
    Publication date: August 17, 2017
    Inventors: Nicolai Vladimirovich Bovin, Stephen Micheal HENRY, Igor Leonidovich RODIONOV
  • Publication number: 20170218027
    Abstract: The invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.
    Type: Application
    Filed: November 14, 2016
    Publication date: August 3, 2017
    Inventors: Nicolai Vladimirovich Bovin, Stephen Micheal Henry, Igor Leonidovich Rodionov, Critsina-Simona Weinberg, Alexander Borisovich Tuzikov
  • Publication number: 20140350217
    Abstract: The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.
    Type: Application
    Filed: February 4, 2014
    Publication date: November 27, 2014
    Applicant: KODE Biotech Limited
    Inventors: Nicolai Vladimirovich Bovin, Stephen Micheal Henry, Igor Leonidovich Rodionov, Cristina-Simona Weinberg, Alexander Borisovich Tuzikov
  • Publication number: 20140161723
    Abstract: Functional-lipid constructs of the structure F-S-L are disclosed, wherein F comprises a tyrosine or histidine residue, S is a spacer covalently linking F to L and L is a lipid. The functional residue may be iodinated and used to radiolabel a biological entity with 1251 and the iodinated constructs are used in a non-invasive method of monitoring the distribution of a biological entity in vivo.
    Type: Application
    Filed: February 9, 2012
    Publication date: June 12, 2014
    Inventors: Nikolai Vladimirovich Bovin, Stephen Henry, Elena Yurievna Korchagina, Igor Leonidovich Rodionov, Alexander Borisovich Tuzikov
  • Patent number: 8669084
    Abstract: The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.
    Type: Grant
    Filed: October 13, 2008
    Date of Patent: March 11, 2014
    Assignee: Kode Biotech Limited
    Inventors: Nicolai Vladimirovich Bovin, Stephen Micheal Henry, Igor Leonidovich Rodionov, Cristina-Simona Weinberg, Alexander Borisovich Tuzikov
  • Publication number: 20120021430
    Abstract: The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates to functional lipid constructs and their use in diagnostic and therapeutic applications, including serodiagnosis, where the functional moiety is a carbohydrate, peptide, chemically reactive group, conjugator or fluorophore.
    Type: Application
    Filed: October 13, 2008
    Publication date: January 26, 2012
    Inventors: Nicolai Vladimirovich Bovin, Stephen Micheal Henry, Igor Leonidovich Rodionov, Cristina-Simona Weinberg, Alexander Borisovich Tuzikov
  • Publication number: 20090142364
    Abstract: The invention describes production of an adjuvant with biological activities related to N-acetylglucosaminyl-?1-4-N-acetylmuramyl-alanyl-D-isoglutamine (GMDP), a commonly used enhancer of the immune response. It was found in the present invention that the drawbacks of GMDP can be avoided by replacing it with a peptide that does not have any direct structural relationship with GMDP.
    Type: Application
    Filed: August 27, 2008
    Publication date: June 4, 2009
    Inventors: Fedor Alexandrovich Brovko, Timo Kalevi Korpela, Alexander Georgievich Laman, Galina Vladimirovna Malakhova, Vladimir Andreevich Nesmeyanov, Igor Leonidovich Rodionov, Anna Olegovna Shepelyakovskaya