Patents by Inventor Ikuo Omura

Ikuo Omura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9040111
    Abstract: A method of making a stent, including preparing a solution containing a composition, the composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, including argatroban, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 3:7, the composition dissolved in a solvent selected from the group consisting of a mixture of a lower alkyl ketone and methanol, a mixture of a lower alkyl ester and methanol or a mixture of a lower halogenated hydrocarbon and methanol; coating at least an outer surface of a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces; and after the coating, removing the solvent to complete a first coated layer.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: May 26, 2015
    Assignees: JAPAN STENT TECHNOLOGY CO., LTD., TOKAI UNIVERSITY EDUCATIONAL SYSTEM, TOYO ADVANCED TECHNOLOGIES CO., LTD.
    Inventors: Ikuo Omura, Zhen Yu Jin, Shuzo Yamashita, Hiroo Iwata, Akira Mochizuki
  • Patent number: 8968392
    Abstract: A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces, a first coated layer coating at least the outer surface of the stent body, the first coated layer being prepared of a first composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, comprising argatroban, which does not inhibit proliferation of endothelial cells, the weight composition ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 7:3, and a second coated layer; and causing argatroban to be released from the stent to thereby inhibit the vascular intimal hyperplasia without inhibiting proliferation of endothelial cells.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: March 3, 2015
    Assignees: Japan Stent Technology Co., Ltd., Tokai University Educational System, Toyo Advanced Technologies Co., Ltd., Hiroo Iwata
    Inventors: Ikuo Omura, Zhen Yu Jin, Shuzo Yamashita, Hiroo Iwata, Akira Mochizuki
  • Patent number: 8641756
    Abstract: A stent includes a stent body of a cylindrical configuration having outer and inner surfaces, a first coated layer coating at least the outer surface, and a second coated layer coating substantially completely over the first coated layer. The first coated layer is prepared of a first composition comprising a polymer and a vascular intimal hyperplasia inhibitor (preferably argatroban) of a kind, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the inhibitor being within the range of 8:2 to 3:7. On the other hand, the second coated layer is prepared of a polymer alone or a second composition comprising a polymer and a drug, the weight compositional ratio of the drug to 80% by weight of the polymer being less than 20% by weight.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: February 4, 2014
    Assignees: Japan Stent Technology Co., Ltd., Tokai University Educational System, Toyo Advanced Technologies Co., Ltd., Hiroo Iwata Institute for Frontier Medical Sciences, Kyoto University
    Inventors: Ikuo Omura, Zhen Yu Jin, Shuzo Yamashita, Hiroo Iwata, Akira Mochizuki
  • Patent number: 8591571
    Abstract: A drug-eluting stent comprises a coated layer prepared of a composition comprising a polymer and a drug, the coated layer being a single coated layer with the composition, or comprises a first coated layer prepared of the above composition and a second coated layer with a polymer alone, the first coated layer being coated by the second coated layer. The drug is a vascular intimal hyperplasia inhibitor which does not inhibit proliferation of endothelial cells, and the composition substantially excludes a lipid-soluble low-molecular compound. The polymer in the first layer is a copolymer of lactic acid (monomer A) and a terminal hydroxy straight alkyl carboxylic acid having 3 to 8 carbon atoms, and, if the second coated layer is formed, the polymer in the second coated layer is a poly(lactic acid), a poly(glycolic acid), or a poly(lactic acid-co-glycolic acid).
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: November 26, 2013
    Assignee: Japan Stent Technology Co., Ltd.
    Inventors: Ikuo Omura, Zhen Yu Jin
  • Patent number: 8409272
    Abstract: A stent includes a stent body of a cylindrical configuration having outer and inner surfaces, a first coated layer coating at least the outer surface, and a second coated layer coating substantially completely over the first coated layer. The first coated layer is prepared of a first composition comprising a polymer and a vascular intimal hyperplasia inhibitor (preferably argatroban) of a kind, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the inhibitor being within the range of 8:2 to 3:7. On the other hand, the second coated layer is prepared of a polymer alone or a second composition comprising a polymer and a drug, the weight compositional ratio of the drug to 80% by weight of the polymer being less than 20% by weight.
    Type: Grant
    Filed: September 3, 2008
    Date of Patent: April 2, 2013
    Assignees: Japan Stent Technology Co., Ltd., Tokai University Educational System, Toyo Advanced Technologies Co., Ltd.
    Inventors: Ikuo Omura, Zhen Yu Jin, Shuzo Yamashita, Hiroo Iwata, Akira Mochizuki
  • Publication number: 20130018455
    Abstract: A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces, a first coated layer coating at least the outer surface of the stent body, the first coated layer being prepared of a first composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, comprising argatroban, which does not inhibit proliferation of endothelial cells, the weight composition ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 7:3, and a second coated layer; and causing argatroban to be released from the stent to thereby inhibit the vascular intimal hyperplasia without inhibiting proliferation of endothelial cells.
    Type: Application
    Filed: July 30, 2012
    Publication date: January 17, 2013
    Applicants: JAPAN STENT TECHNOLOGY CO., LTD., HIROO IWATA, TOYO ADVANCED TECHNOLOGIES CO., LTD., TOKAI UNIVERSITY EDUCATIONAL SYSTEM
    Inventors: Ikuo Omura, Zhen Yu Jin, Shuzo Yamashita, Hiroo Iwata, Akira Mochizuki
  • Publication number: 20120310329
    Abstract: A stent includes a stent body of a cylindrical configuration having outer and inner surfaces, a first coated layer coating at least the outer surface, and a second coated layer coating substantially completely over the first coated layer. The first coated layer is prepared of a first composition comprising a polymer and a vascular intimal hyperplasia inhibitor (preferably argatroban) of a kind, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the inhibitor being within the range of 8:2 to 3:7. On the other hand, the second coated layer is prepared of a polymer alone or a second composition comprising a polymer and a drug, the weight compositional ratio of the drug to 80% by weight of the polymer being less than 20% by weight.
    Type: Application
    Filed: June 8, 2012
    Publication date: December 6, 2012
    Applicants: JAPAN STENT TECHNOLOGY CO., LTD., HIROO IWATA, TOYO ADVANCED TECHNOLOGIES CO., LTD., TOKAI UNIVERSITY EDUCATIONAL SYSTEM
    Inventors: Ikuo OMURA, Zhen Yu JIN, Shuzo YAMASHITA, Hiroo IWATA, Akira MOCHIZUKI
  • Publication number: 20110313514
    Abstract: A drug-eluting stent comprises a coated layer prepared of a composition comprising a polymer and a drug, the coated layer being a single coated layer with the composition, or comprises a first coated layer prepared of the above composition and a second coated layer with a polymer alone, the first coated layer being coated by the second coated layer. The drug is a vascular intimal hyperplasia inhibitor which does not inhibit proliferation of endothelial cells, and the composition substantially excludes a lipid-soluble low-molecular compound. The polymer in the first layer is a copolymer of lactic acid (monomer A) and a terminal hydroxy straight alkyl carboxylic acid having 3 to 8 carbon atoms, and, if the second coated layer is formed, the polymer in the second coated layer is a poly(lactic acid), a poly(glycolic acid), or a poly(lactic acid-co-glycolic acid).
    Type: Application
    Filed: August 25, 2011
    Publication date: December 22, 2011
    Applicant: JAPAN STENT TECHNOLOGY CO., LTD.
    Inventors: Ikuo Omura, Zhen Yu Jin
  • Publication number: 20100249914
    Abstract: A stent includes a stent body of a cylindrical configuration having outer and inner surfaces, a first coated layer coating at least the outer surface, and a second coated layer coating substantially completely over the first coated layer. The first coated layer is prepared of a first composition comprising a polymer and a vascular intimal hyperplasia inhibitor (preferably argatroban) of a kind, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the inhibitor being within the range of 8:2 to 3:7. On the other hand, the second coated layer is prepared of a polymer alone or a second composition comprising a polymer and a drug, the weight compositional ratio of the drug to 80% by weight of the polymer being less than 20% by weight.
    Type: Application
    Filed: June 2, 2010
    Publication date: September 30, 2010
    Applicants: HIROO IWATA
    Inventors: Ikuo Omura, Zhen Yu Jin, Shuzo Yamashita, Hiroo Iwata, Akira Mochizuki
  • Publication number: 20100198344
    Abstract: A stent includes a stent body of a cylindrical configuration having outer and inner surfaces, a first coated layer coating at least the outer surface, and a second coated layer coating substantially completely over the first coated layer. The first coated layer is prepared of a first composition comprising a polymer and a vascular intimal hyperplasia inhibitor (preferably argatroban) of a kind, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the inhibitor being within the range of 8:2 to 3:7. On the other hand, the second coated layer is prepared of a polymer alone or a second composition comprising a polymer and a drug, the weight compositional ratio of the drug to 80% by weight of the polymer being less than 20% by weight.
    Type: Application
    Filed: September 3, 2008
    Publication date: August 5, 2010
    Applicants: Japan Stent Technology Co., Ltd., Tokai University Educational System, Toyo Advanced Technologies Co., Ltd.
    Inventors: Ikuo Omura, Zhen Yu Jin, Shuzo Yamashita, Hiroo Iwata, Akira Mochizuki
  • Patent number: 6984673
    Abstract: One embodiment of the invention provides a dental cement composition which includes (a) an acid group-having polymerizable monomer, (b) a polyalkenoic acid, (c) an ion-leachable glass filler, (d) a polymerizable monomer not having an acid group, (e) water, (f) a peroxide, (g) a salt of an aromatic sulfinic acid, and (h) an aromatic secondary amine and/or an aromatic tertiary amine.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: January 10, 2006
    Assignee: Kuraray Co., Ltd.
    Inventors: Mitsunobu Kawashima, Ikuo Omura, Mayumi Yamashita
  • Patent number: 6869984
    Abstract: The invention refers to a dental composition kit which comprises a combination of (A) a one-pack primer composition containing (a) an acid group-having polymerizable monomer and (b) an aromatic secondary amine and/or an aromatic tertiary amine, and (B) a cement composition containing (c) a polyalkenoic acid, (d) an ion-leachable glass filler, (e) a polymerizable monomer, (f) water, (g) a peroxide and (h) a salt of an aromatic sulfinic acid. A dental composition kit of this invention is easy to handle, and the cured product of the compositions bonds well to teeth. The kit is useful in restoring decayed or injured teeth and in bonding prostheses to teeth.
    Type: Grant
    Filed: June 17, 2002
    Date of Patent: March 22, 2005
    Assignee: Kuraray Co., Ltd.
    Inventors: Mitsunobu Kawashima, Ikuo Omura, Mayumi Yamashita
  • Publication number: 20030083398
    Abstract: The invention refers to a dental composition kit which comprises a combination of (A) a one-pack primer composition containing (a) an acid group-having polymerizable monomer and (b) an aromatic secondary amine and/or an aromatic tertiary amine, and (B) a cement composition containing (c) a polyalkenoic acid, (d) an ion-leachable glass filler, (e) a polymerizable monomer, (f) water, (g) a peroxide and (h) a salt of an aromatic sulfinic acid. A dental composition kit of this invention is easy to handle, and the cured product of the compositions bonds well to teeth. The kit is useful in restoring decayed or injured teeth and in bonding prostheses to teeth.
    Type: Application
    Filed: June 17, 2002
    Publication date: May 1, 2003
    Applicant: KURARAY CO. LTD.
    Inventors: Mitsunobu Kawashima, Ikuo Omura, Mayumi Yamashita
  • Publication number: 20030055123
    Abstract: One embodiment of the invention provides a dental cement composition which includes (a) an acid group-having polymerizable monomer, (b) a polyalkenoic acid, (c) an ion-leachable glass filler, (d) a polymerizable monomer not having an acid group, (e) water, (f) a peroxide, (g) a salt of an aromatic sulfinic acid, and (h) an aromatic secondary amine and/or an aromatic tertiary amine.
    Type: Application
    Filed: June 28, 2002
    Publication date: March 20, 2003
    Applicant: KURARAY CO. LTD,
    Inventors: Mitsunobu Kawashima, Ikuo Omura, Mayumi Yamashita
  • Patent number: 6310116
    Abstract: A molded polymer article comprises a main molded body having on the surface thereof a hydrophilic polymer layer, the article being obtained by polymerizing both a monomer having a hydrophilic group and coated on the surface of a hydrophilic mold, and a polymerizable composition consisting essentially of a monomer and/or oligomer and placed in the mold. The hydrophilic polymer layer has excellent adhesiveness to the main body of the molded polymer article and excellent durability, so that the high hydrophilic property can be maintained, even when the article is exposed to external forces such as friction, over a long period of time. The molded articles are therefore useful as, in particular, contact lenses.
    Type: Grant
    Filed: September 18, 1998
    Date of Patent: October 30, 2001
    Assignee: Kuraray Co., Ltd.
    Inventors: Tokugen Yasuda, Hitoshi Inoue, Satsuki Kitajima, Masahiro Sato, Wu Yang, Ikuo Omura
  • Patent number: 6262208
    Abstract: Ocular lens materials is made from copolymers prepared by polymerizing a monomer mixture containing: (A) an N-vinyllactam; (B) a fluorine-containing unsaturated monomer; (C) a hydrophilic (meth)acrylamide; (D) a crosslinking agent having at least 2 (meth)acryloyloxy groups; and (E) a dicarboxylic acid divinyl ester. These ocular lens materials and ocular lenses causing no elution and have a high water-retaining capability, oxygen permeability, are excellent in transparency, resistance to deposition, mechanical strength, flexibility, safety, durability, correction of visual acuity, and comfort during wear.
    Type: Grant
    Filed: March 8, 1999
    Date of Patent: July 17, 2001
    Assignee: Kuraray Co., Ltd.
    Inventors: Takashi Makabe, Ikuo Omura
  • Patent number: 5486544
    Abstract: A polymerizable composition comprising:(a) a monomer; and(b) a sulfinate represented by the formula (I): ##STR1## wherein R.sup.1 and R.sup.5 each represents a substituent having 2 to 6 carbon atoms, R.sup.2, R.sup.3 and R.sup.4 each represents an atom or substituent inert to the monomer (a), M.sup.n+ represents a n-valent cation, and n represents an integer of 1 to 4.
    Type: Grant
    Filed: September 12, 1994
    Date of Patent: January 23, 1996
    Assignee: Kuraray Co., Ltd.
    Inventors: Mitsunobu Kawashima, Ikuo Omura
  • Patent number: 5254198
    Abstract: An adhesive composition comprising a polymerizable thiocarboxylic acid or a derivative thereof of the general formula ##STR1## wherein X.sub.1 is an oxygen atom or a sulfur atom and where X.sub.1 is an oxygen atom, R.sub.1 is an organic group containing at least one olefinic double bond and R.sub.2 is a mercapto group, and where X.sub.1 is a sulfur atom, R.sub.1 is an organic group and R.sub.2 is a mercapto group, a halogen atom, --OR.sub.3, or --SR.sub.3, where R.sub.3 is a monovalent organic group, and at least one of R.sub.1 and R.sub.3 has at least one olefinic double bond, are useful as primers or adhesives and provide a water-resistant, high-strength bond to noble metal adherends which are used in dental and other applications.
    Type: Grant
    Filed: June 3, 1992
    Date of Patent: October 19, 1993
    Assignee: Kuraray Co., Ltd.
    Inventors: Mitsunobu Kawashima, Ikuo Omura
  • Patent number: 5192815
    Abstract: Provided is a dental restorative material having high mechanical strength, abrasion resistance, hardness and excellent aesthetic appearance because it contains a large amount of an ultrafine filler having a particle size of 0.1 .mu.m or less, and can hence be used for restoring molars as well as foreteeth. The dental restorative material comprises an inorganic filler with a size of 0.1 .mu.m or less which is insoluble in water and surface-treated with a silane coupling agent represented by the following general formula: ##STR1## and a (meth)acrylate monomer composition containing at least 50% by weight based on the weight of the composition of at least one hydrophobic multifunctional (meth)acrylate represented by the following general formula: ##STR2## said surface-treated inorganic filler being incorporated in an amount of at least 100 parts by weight based on 100 parts by weight of said monomer composition.
    Type: Grant
    Filed: November 2, 1989
    Date of Patent: March 9, 1993
    Assignee: Kuraray Co., Ltd.
    Inventors: Koichi Okada, Ikuo Omura
  • Patent number: 5186783
    Abstract: An adhesive composition comprising a polymerizable thiocarboxylic acid or a derivative thereof of the general formula ##STR1## wherein X.sub.1 is an oxygen atom or a sulfur atom and where X.sub.1 is an oxygen atom, R.sub.1 is an organic group containing at least one olefinic double bond and R.sub.2 is a mercapto group, and where X.sub.1 is a sulfur atom, R.sub.1 is an organic group and R.sub.2 is a mercapto group, a halogen atom, --OR.sub.3, or --SR.sub.3, where R.sub.3 is a monovalent organic group, and at least one of R.sub.1 and R.sub.3 has at least one olefinic double bond, are useful as primers or adhesives and provide a water-resistant, high-strength bond to noble metal adherends which are used in dental and other applications.
    Type: Grant
    Filed: February 28, 1991
    Date of Patent: February 16, 1993
    Assignee: Kuraray Co., Ltd.
    Inventors: Mitsunobu Kawashima, Ikuo Omura