Patents by Inventor Ilya Fine
Ilya Fine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140200423Abstract: A pulse oximetry device that is mounted on a wrist strap and fixates an area above a distal end of the ulna with a dome shaped structure. This area is used as measuring area. The measurement is carried out by a detector positioned above the fixated area, that detects light emitted by light sources having different wave lengths that are located at a periphery of the fixated area. Hence, the reflections are measured at neither a reflection mode nor a transmission mode, but are at an angle between 20° and 160° from the emitted light. This mode, termed trans-illumination, allows achieving an excellent signal to noise ratio that for the first time enables continuous and reliable measurement of oximetry data on the wrist.Type: ApplicationFiled: August 26, 2012Publication date: July 17, 2014Applicant: Oxitone Medical Ltd.Inventors: Leon Eisen, Ilya Fine, Leonid Goldinov
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Patent number: 8708907Abstract: Embodiments of the present invention relate to a system and method for in vivo measurement of blood parameters by processing analog electrical signals from a plurality of photodetectors. In some embodiments, it is possible to determine one or more blood parameters according to (i) a first electrical signal from a first detector and (ii) a second electrical signal from a second photodetector. A difference analog electrical signal is generated, indicative of a difference between the light response signal at the first location and light response signal at the second location, is generated. One or more blood parameters may be detected according to the difference analog electrical signal.Type: GrantFiled: May 5, 2010Date of Patent: April 29, 2014Assignee: Elfi-TechInventors: Ilya Fine, Alexander Kaminsky
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Publication number: 20140094666Abstract: A system, method and medical tool are presented for use in non-invasive in vivo determination of at least one desired parameter or condition of a subject having a scattering medium in a target region. The measurement system comprises an illuminating system, a detection system, and a control system. The illumination system comprises at least one light source configured for generating partially or entirely coherent light to be applied to the target region to cause a light response signal from the illuminated region. The detection system comprises at least one light detection unit configured for detecting time-dependent fluctuations of the intensity of the light response and generating data indicative of a dynamic light scattering (DLS) measurement. The control system is configured and operable to receive and analyze the data indicative of the DLS measurement to determine the at least one desired parameter or condition, and generate output data indicative thereof.Type: ApplicationFiled: September 28, 2012Publication date: April 3, 2014Applicant: ELFI-TECH LTD.Inventor: Ilya FINE
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Publication number: 20130131475Abstract: A system and method for measuring one or more light-absorption related blood analyte concentration parameters of a mammalian subject, is disclosed. In some embodiments, the system comprises: a) a photoplethysmography (PPG) device configured to effect a PPG measurement by illuminating skin of the subject with at least two distinct wavelengths of light and determining relative absorbance at each of the wavelengths; b) a dynamic light scattering measurement (DLS) device configured to effect a DLS measurement of the subject to rheologically measure a pulse parameter of the subject; and c) electronic circuitry configured to: i) temporally correlating the results of the PPG and DLS measurements; and ii) accordance with the temporal correlation between the PPG and DLS measurements, assessing value(s) of the one or more light-absorption related blood analyte concentration parameter(s).Type: ApplicationFiled: October 16, 2012Publication date: May 23, 2013Inventors: Leon Eisen, Alexander Kamisnky, Ilya Fine
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Patent number: 8277384Abstract: A system, method and medical tool are presented for use in non-invasive in vivo determination of at least one desired parameter or condition of a subject having a scattering medium in a target region. The measurement system comprises an illuminating system, a detection system, and a control system. The illumination system comprises at least one light source configured for generating partially or entirely coherent light to be applied to the target region to cause a light response signal from the illuminated region. The detection system comprises at least one light detection unit configured for detecting time-dependent fluctuations of the intensity of the light response and generating data indicative of a dynamic light scattering (DLS) measurement. The control system is configured and operable to receive and analyze the data indicative of the DLS measurement to determine the at least one desired parameter or condition, and generate output data indicative thereof.Type: GrantFiled: April 28, 2009Date of Patent: October 2, 2012Inventor: Ilya Fine
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Publication number: 20120130215Abstract: The present invention relates to an apparatus and method for optical measurement of a parameter related to motion of light-scattering particles within a fluid by manipulating analog electrical signals. In some embodiments, first and second analog signals are respectively obtained from first and second photodetectors respectively located at first and second locations. A technique is disclosed for boosting a fraction of an analog electrical signal attributable to light scattering fluctuations and/or to stochastic effects and/or to speckle measurements and/or to DLS measurements. According to this technique, a hybrid analog signal or a difference analog signals is obtained from the first and second analog signals, and is analyzed. Exemplary fluids include but are not limited to biological fluids (e.g. blood plasma). Teachings disclosed herein may be employed in vitro or in vivo.Type: ApplicationFiled: November 9, 2011Publication date: May 24, 2012Inventors: Ilya Fine, Alexander Kaminsky
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Publication number: 20110082355Abstract: A system and method for measuring one or more light-absorption related blood analyte concentration parameters of a mammalian subject, is disclosed. In some embodiments, the system comprises: a) a photoplethysmography (PPG) device configured to effect a PPG measurement by illuminating skin of the subject with at least two distinct wavelengths of light and determining relative absorbance at each of the wavelengths; b) a dynamic light scattering measurement (DLS) device configured to effect a DLS measurement of the subject to rheologically measure a pulse parameter of the subject; and c) electronic circuitry configured to: i) temporally correlating the results of the PPG and DLS measurements; and ii) accordance with the temporal correlation between the PPG and DLS measurements, assessing value(s) of the one or more light-absorption related blood analyte concentration parameter(s).Type: ApplicationFiled: July 30, 2010Publication date: April 7, 2011Applicant: OxiTone Medical Ltd.Inventors: Leon Eisen, Alexander Kamisnky, Ilya Fine
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Publication number: 20110033385Abstract: A method and apparatus are presented for non-invasive determination of blood clotting related and blood circulation related parameters of a mammal. At least one stimulus ST is non-invasively induced in a blood containing medium in the mammal for a preset period of time tST. This at least one stimulus is selected to cause at least one of the following to occur: (a) inducing at least two of three Virchow's triad elements including abnormalities of blood flow; abnormalities of blood constituents and abnormalities of the blood vessel wall, and (b) inducing a change in red blood cell (RBC) aggregation or local blood viscosity. Measurements are non-invasively performed at a measurement location in the mammal by applying an external field thereto for a preset time period tm, a response of the measurement location to the applied field is detected, and measured data indicative thereof generated.Type: ApplicationFiled: July 14, 2010Publication date: February 10, 2011Applicant: ELFI-Tech Ltd.Inventors: Ilya Fine, Leonid Shvartsman
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Publication number: 20100286497Abstract: Embodiments of the present invention relate to a system and method for in vivo measurement of blood parameters by processing analog electrical signals from a plurality of photodetectors. In some embodiments, it is possible to determine one or more blood parameters according to (i) a first electrical signal from a first detector and (ii) a second electrical signal from a second photodetector. A difference analog electrical signal is generated, indicative of a difference between the light response signal at the first location and light response signal at the second location, is generated. One or more blood parameters may be detected according to the difference analog electrical signal.Type: ApplicationFiled: May 5, 2010Publication date: November 11, 2010Inventors: Ilya Fine, Alexander Kaminsky
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Patent number: 7758505Abstract: A method and apparatus are presented for non-invasive determination of blood clotting related and blood circulation related parameters of a mammal. At least one stimulus ST is non-invasively induced in a blood containing medium in the mammal for a preset period of time tST. This at least one stimulus is selected to cause at least one of the following to occur: (a) inducing at least two of three Virchow's triad elements including abnormalities of blood flow; abnormalities of blood constituents and abnormalities of the blood vessel wall, and (b) inducing a change in red blood cell (RBC) aggregation or local blood viscosity. Measurements are non-invasively performed at a measurement location in the mammal by applying an external field thereto for a preset time period tm, a response of the measurement location to the applied field is detected, and measured data indicative thereof generated.Type: GrantFiled: November 27, 2006Date of Patent: July 20, 2010Assignee: ELFI-Tech Ltd.Inventors: Ilya Fine, Leonid Shvartsman
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Publication number: 20090209834Abstract: A system, method and medical tool are presented for use in non-invasive in vivo determination of at least one desired parameter or condition of a subject having a scattering medium in a target region. The measurement system comprises an illuminating system, a detection system, and a control system. The illumination system comprises at least one light source configured for generating partially or entirely coherent light to be applied to the target region to cause a light response signal from the illuminated region. The detection system comprises at least one light detection unit configured for detecting time-dependent fluctuations of the intensity of the light response and generating data indicative of a dynamic light scattering (DLS) measurement. The control system is configured and operable to receive and analyze the data indicative of the DLS measurement to determine the at least one desired parameter or condition, and generate output data indicative thereof.Type: ApplicationFiled: April 28, 2009Publication date: August 20, 2009Applicant: ELFI-TECH LTD.Inventor: Ilya FINE
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Publication number: 20090082642Abstract: Disclosed is a system and method for use in monitoring of biological parameters of a subject. The system includes an illumination unit including at least one light source of at least one pre-selected wavelength band, to be applied to a selected region in the subject; and a detection system configured for measuring reflections of the light at different angles and different spatial locations with respect to the illuminated region. The detection system is configured and operable to detect spatially separated light components corresponding to the specular dependent component of the signal and the pulsatile-related diffused component of the signal coming from the subject in different directions respectively, thereby defining at least two independent channels of information, enabling identification of the reflected signal part dependent on motion effects.Type: ApplicationFiled: December 8, 2008Publication date: March 26, 2009Applicant: ELFI-TECH LTD.Inventor: Ilya FINE
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Patent number: 7386336Abstract: A method and device are presented for use in non-invasive optical measurements of at least one desired characteristic of patient's blood. A condition of artificial blood kinetics is created at a measurement location in a patient's blood perfused fleshy medium and maintained for a certain time period. This condition is altered over a predetermined time interval within said certain time period so as to modulate scattering properties of blood. Optical measurements are applied to the measurement location by illuminating it with incident light beams of at least two different wavelengths in a range where the scattering properties of blood are sensitive to light radiation, detecting light responses of the medium, and generating measured data indicative of time evolutions of the light responses of the medium for said at least two different wavelengths, respectively, over at least a part of said predetermined time interval.Type: GrantFiled: January 30, 2006Date of Patent: June 10, 2008Assignee: ORSENSE Ltd.Inventors: Ilya Fine, Alexander Finarov
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Patent number: 7317939Abstract: A method for optical measurements of desired parameters of the patient's blood is presented. A state of the blood flow cessation is provided within a measurement region and maintained during a predetermined time period. Measurement sessions are performed within this predetermined time period. Each measurement session includes at least two measurements with different wavelengths of incident light. Obtained measured data is representative of the time dependence of light response of the blood in the measurement region. The analyses of the measured data enables the determination of the desired blood parameters extracted from optical characteristics associated with the erythrocytes aggregation process during the state of the blood flow cessation.Type: GrantFiled: April 24, 2006Date of Patent: January 8, 2008Assignee: Orsense Ltd.Inventors: Ilya Fine, Leonid Shvartsman
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Patent number: 7313425Abstract: An optical measurement device and method are presented for use in non-invasive measurements on a patient's body. The device comprises an illumination assembly configured and operable to generate illuminating light of a predetermined wavelength range; a detection assembly; and a light directing assembly. The detection assembly comprises a first detector unit for detecting a first light signal transmitted through an illuminated body portion and generating first measured data indicative of the detected transmitted light, and a second detector unit for detecting a second light signal reflected from the illuminated body portion and generating second measured data indicative of the detected reflected light. The light directing assembly comprises a light diffuser for scattering back light incident thereto, to thereby direct the illuminating light or the light coming from the body portion back towards the body portion.Type: GrantFiled: July 8, 2004Date of Patent: December 25, 2007Assignee: Orsense Ltd.Inventors: Alexander Finarov, Ilya Fine
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Publication number: 20070232940Abstract: A method and apparatus are presented for non-invasive determination of blood clotting related and blood circulation related parameters of a mammal. At least one stimulus ST is non-invasively induced in a blood containing medium in the mammal for a preset period of time tST. This at least one stimulus is selected to cause at least one of the following to occur: (a) inducing at least two of three Virchow's triad elements including abnormalities of blood flow; abnormalities of blood constituents and abnormalities of the blood vessel wall, and (b) inducing a change in red blood cell (RBC) aggregation or local blood viscosity. Measurements are non-invasively performed at a measurement location in the mammal by applying an external field thereto for a preset time period tm, a response of the measurement location to the applied field is detected, and measured data indicative thereof generated.Type: ApplicationFiled: November 27, 2006Publication date: October 4, 2007Applicant: ELFI-TECH LTDInventors: Ilya Fine, Leonid Shvartsman
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Patent number: 7266400Abstract: A method and device are provided for self-monitoring a patient's blood glucose condition to determine a long-term effect of the patient's behavior on his blood glucose level. A sequence of measurements of the blood glucose level is applied during a day, the sequential measurements are repeated during a predetermined time period from several days to several weeks, and measured data are collected. The measured data is analyzed to determine a distribution of the average glucose values within said predetermined time period, thereby providing a feedback for the patient or an authorized person.Type: GrantFiled: May 6, 2003Date of Patent: September 4, 2007Assignee: Orsense Ltd.Inventors: Ilya Fine, Lior Ma'Ayan
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Patent number: 7254432Abstract: A method and system for non-invasive measurements in a patient's body in which several measurement sessions are performed on a measurement location. Each measurement session includes applying an external electromagnetic field to the measurement location, detecting at least two responses of the measurement location, and generating data indicative of the detected response. These responses are characterized by at least two different values of a controllable parameter. The measurement sessions include at least two measurement sessions carried out at a normal blood flow in the measurement location and at least two measurement sessions carried out at a condition of artificial kinetics in the measurement location. The first and second measured data are processed to determine a first relation between the first time variations and a second relation between the second time variations for the different parameter. that can be used to determine the at least one blood related parameter.Type: GrantFiled: August 17, 2005Date of Patent: August 7, 2007Assignee: Orsense Ltd.Inventor: Ilya Fine
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Publication number: 20070078312Abstract: A method and system are presented for use in non-invasive measurements in a patient's body. A condition of artificial blood kinetics is created at a measurement location in a patient's blood perfused fleshy medium, and this condition is maintained for a certain time period. An external electromagnetic field is applied to the measurement location while under the condition of artificial blood kinetics. A time variation of a response of the blood perfused fleshy medium to this external electromagnetic field is detected, and measured data indicative thereof is generated. The response of the medium can be a photo-acoustic signal obtained in response to incident light, and/or impedance of the medium in response to the applied ac electromagnetic field.Type: ApplicationFiled: May 8, 2006Publication date: April 5, 2007Applicant: Orense Ltd.Inventors: Ilya Fine, Alexander Finarov, Iosef Gandelman, Boris Fikhte
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Publication number: 20060200014Abstract: A method for optical measurements of desired parameters of the patient's blood is presented. A state of the blood flow cessation is provided within a measurement region and maintained during a predetermined time period. Measurement sessions are performed within this predetermined time period. Each measurement session includes at least two measurements with different wavelengths of incident light. Obtained measured data is representative of the time dependence of light response of the blood in the measurement region. The analyses of the measured data enables the determination of the desired blood parameters extracted from optical characteristics associated with the erythrocytes aggregation process during the state of the blood flow cessation.Type: ApplicationFiled: April 24, 2006Publication date: September 7, 2006Applicant: ORSENSE LTD.Inventors: Ilya Fine, Leonid Shvartsman