Patents by Inventor Ineke VAN Wijngaarden

Ineke VAN Wijngaarden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • New 1,4-diazepine derivatives having anit-ulcer activity
    Patent number: 4985423
    Abstract: The invention relates to a group of new 1,4-diazepine derivatives of the formula ##STR1## wherein A represents a group of the formulae 2-10 ##STR2## These compounds have a strong anti-ulcer activity after oral administration.
    Type: Grant
    Filed: July 3, 1989
    Date of Patent: January 15, 1991
    Assignee: Duphar International Research B.V.
    Inventors: Jacobus A. J. den Hartog, Herman H. van Stuivenberg, Ineke van Wijngaarden
  • 1,7-annelated indolecarboxylic acid esters and -amides
    Patent number: 4985420
    Abstract: The invention relates to new 1,7-annelated esters and amides of indolecarboxylic acids having general formula 2, ##STR1## wherein the symbols have the meanings given in the specification. The compounds and their salts are very strong and selective antagonists of "neuronal" 5-hydroxytryptamine (5-HT) receptors, and can be used for the treatment of symptoms which are caused by over-stimulation of these receptors.
    Type: Grant
    Filed: December 7, 1988
    Date of Patent: January 15, 1991
    Assignee: Duphar International Research B.V.
    Inventors: Derk Hamminga, Hans H. Haeck, Ineke Van Wijngaarden, Wouter Wouters
  • Certain substituted 1,7-annelated 1h-indazoles being selective antagonists of 5-ht-receptors
    Patent number: 4985424
    Abstract: The invention relates to a group of new substituted 1,7-annelated 1H-indazole derivatives being strong and selective antagonists of "neuronal" 5-hydroxytryptamine (5-HT) receptors.
    Type: Grant
    Filed: June 12, 1990
    Date of Patent: January 15, 1991
    Assignee: Duphar International Research B.V.
    Inventors: Ineke van Wijngaarden, Derk Hamminga, Hans H. Haeck, Wouter Wouters
  • Substituted 1,7-annelated 1H-indazoles
    Patent number: 4950759
    Abstract: The invention relates to a group of new substituted 1,7-annelated 1H-indazole derivatives being strong and selective antagonists of "neuronal" 5-hydroxytryptamine (5-HT) receptors.
    Type: Grant
    Filed: July 3, 1989
    Date of Patent: August 21, 1990
    Assignee: Duphar International Research B.V.
    Inventors: Ineke van Wijngaarden, Derk Hamminga, Hans H. Haeck, Wouter Wouters
  • New anellated indole derivatives
    Patent number: 4939136
    Abstract: The invention relates to new anellated indole derivatives of general formula 2, ##STR1## wherein p1 R.sub.0 is alkyl or alkoxy having 1-4 C-atoms, phenylalkoxy having 1-3 C-atoms in the alkoxy group, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, or a group R.sub.7 S(O).sub.p, wherein R.sub.7 is alkyl having 1-4 C-atoms and p has the value 0, 1 or 2, or R.sub.0 is a group R.sub.8 R.sub.9 N, R.sub.8 R.sub.9 N--CO--CH.sub.2 -- or R.sub.8 R.sub.9 --N--CO wherein R.sub.8 and R.sub.9 are hydrogen or alkyl having 1-4 C-atoms or R.sub.8 R.sub.9 N forms a saturated 5- or 6-membered ring and n has the value 0, 1 or 2, Z together with the carbon atom and nitrogen atom to which Z is bound and the intermediate carbon atom, forms a heterocyclic group consisting of 5-8 ring atoms, in which, in addition to the nitrogen atom already present, a --CO--group or a second hetero atom from the group N, O, S, S-O or SO.sub.
    Type: Grant
    Filed: June 24, 1988
    Date of Patent: July 3, 1990
    Assignee: Duphar International Research B.V.
    Inventors: Hans H. Haeck, Derk Hamminga, Ineke Van Wijngaarden, Wouter Wouters
  • Spasmolytically active tertiary amine derivatives
    Patent number: 4889849
    Abstract: The invention relates to new spasmolytically active tertiary amine derivatives and the salts thereof, of the formula (1) ##STR1## wherein the symbols have the following meanings: .circle.A is phenyl, or a 5- or 6-membered aromatic group containing 1 or 2 of the following hetero atoms: oxygen and/or sulphur and/or nitrogen;R.sub.1 and R.sub.2 may be equal or different and are hydrogen or substituents;R.sub.3 is a hydrogen atom or, together with R.sub.4, may form a ring consisting of 6 or 7 carbon atoms;R.sub.4 is a hydrogen atom or alkyl group having 1-3 carbon atoms;R.sub.5 is a straight, branched or cyclic alkyl group having 1-4 carbon atoms;R.sub.6 is a straight or branched, saturated or unsaturated alkylene group having a chain length of 2-6 carbon atoms;Z is the group NR.sub.12, wherein R.sub.12 is a hydrogen atom or an alkyl group having 1-3 carbon atoms, or Z is an oxygen atom;n has the value 0 or 1;X is a carbonyl group, thiocarbonyl group or SO.sub.2 group;R.sub.7 and R.sub.
    Type: Grant
    Filed: January 9, 1989
    Date of Patent: December 26, 1989
    Assignee: Duphar International Research B.V.
    Inventors: Ineke Van Wijngaarden, Johannes M. A. Zwagemakers, Jan Van Dijk
  • Aryl-substituted (N-piperidinyl)methyl- and (N-piperidinyl) methylazoles having antipsychotic properties
    Patent number: 4874770
    Abstract: The invention relates to new aryl-substituted (N-piperidinyl)methyl- and (N-piperazinyl)methylazoles having interesting pharmacological, notably antipsychotic, properties.The compounds may be prepared in a manner known for the synthesis of analogous compounds and be processed to compositions according to known methods.
    Type: Grant
    Filed: July 1, 1988
    Date of Patent: October 17, 1989
    Assignee: Duphar International Research B.V.
    Inventors: Ineke Van Wijngaarden, Cornelis Kruse, Johannes A. M. Van Der Heyden, Martinus T. M. Tulp
  • Phenyl, Pyrrolidin-2-yl substituted pyrroles having antipsychotic properties
    Patent number: 4791132
    Abstract: The invention relates to a group of new phenyl, pyrrolidin-2-yl substituted 5-ring heterocyclic compounds of the formula ##STR1## wherein A is an unsaturated heterocyclic 5-ring having at least one nitrogen or oxygen atom in the ring, with the proviso that the phenyl substituent is in a meta-position with respect to the 2-pyrrolidinyl substituent.The compounds have interesting pharmacological, notably antipsychotic properties.
    Type: Grant
    Filed: September 9, 1987
    Date of Patent: December 13, 1988
    Assignee: Duphar International Research B.V.
    Inventors: Ineke Van Wijngaarden, Cornelis G. Kruse, Roelof Van Hes, Johannes A. M. Van Der Heyden
  • Method of treating psychotropic conditions employing substituted piperazine compounds
    Patent number: 4782061
    Abstract: The invention relates to a group of new bicyclic heteroarylpiperazine derivatives of formula 1. It was found that these compounds have interesting psychotropic in particular anti-psychotic properties.The compounds can be prepared according to methods known for the synthesis of analogous compounds.
    Type: Grant
    Filed: December 18, 1985
    Date of Patent: November 1, 1988
    Assignee: Duphar International Research B.V.
    Inventors: Cornelis G. Kruse, Johannes A. M. van der Heyden, Ineke van Wijngaarden, Jan Hartog, Berend Olivier
  • Phenyl-substituted (N-piperazinyl) methylazoles for treating affections in the central nervous system
    Patent number: 4772604
    Abstract: The invention relates to new aryl-substituted (N-piperidinyl)methyl- and (N-piperazinyl)methylazoles having interesting pharmacological, notably antipsychotic, properties.The compounds may be prepared in a manner known for the synthesis of analogous compounds and be processed to compositions according to known methods.
    Type: Grant
    Filed: February 24, 1987
    Date of Patent: September 20, 1988
    Assignee: Duphar International Research B.V.
    Inventors: Ineke van Wijngaarden, Cornelis G. Kruse, Johannes A. M. van der Heyden, Martinus T. M. Tulp
  • 1-[(Diarylmethyl)aminoalkyl]piperidimes
    Patent number: 4082755
    Abstract: Novel compounds of the class of 1-[(diarylmethyl)aminoalkyl]piperidines having neuroleptic activity.
    Type: Grant
    Filed: February 14, 1977
    Date of Patent: April 4, 1978
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ineke van Wijngaarden, Willem Soudijn, Jan Vandenberk, Jozef Fr. Hens
  • N-[(1-piperidinyl)alkyl]arylcarboxamide derivatives
    Patent number: 4031226
    Abstract: Compounds of the class of N-[(1-piperidinyl)alkyl]arylcarboxamides, useful as antiemetic and psychotropic agents.
    Type: Grant
    Filed: June 21, 1976
    Date of Patent: June 21, 1977
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Willem Soudijn, Ineke VAN Wijngaarden, Paul Adriaan Jan Janssen