Patents by Inventor Irvith M. Carvajal

Irvith M. Carvajal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GLYPICAN-3-BINDING FIBRONECTIN BASED SCAFFOLD MOLECULES
    Publication number: 20230312686
    Abstract: Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a 10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 10Fn3 drug conjugates are also provided.
    Type: Application
    Filed: November 10, 2022
    Publication date: October 5, 2023
    Inventors: Dasa LIPOVSEK, Joseph TOTH, Ginger C, RAKESTRAW, Irvith M. CARVAJAL, Stanley Richard KRYSTEK, JR., Steven R. O'NEIL, Guodong CHEN, Richard Y. HUANG, Bryan C. BARNHART, John Thomas LOFFREDO, III, Christina TERRAGNI
  • Glypican-3-binding fibronectin based scaffold molecules
    Patent number: 11524992
    Abstract: Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a 10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 10Fn3 drug conjugates are also provided.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: December 13, 2022
    Assignee: Bristol-Myers Squibb Company
    Inventors: Dasa Lipovsek, Joseph Toth, Ginger C. Rakestraw, Irvith M. Carvajal, Stanley Richard Krystek, Jr., Steven R. O'Neil, Guodong Chen, Richard Y. Huang, Bryan C. Barnhart, John Thomas Loffredo, Christina Terragni
  • MULTIVALENT FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS
    Publication number: 20210017252
    Abstract: The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
    Type: Application
    Filed: August 6, 2020
    Publication date: January 21, 2021
    Inventors: Ray CAMPHAUSEN, Eric FURFINE, Irvith M. CARVAJAL, H. Nicholas MARSH, Marco GOTTARDIS, Joan CARBONI, Ricardo ATTAR
  • Method of treating cancer by administering multivalent fibronectin based scaffold domain proteins
    Patent number: 10774130
    Abstract: The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: September 15, 2020
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Ray Camphausen, Eric Furfine, Irvith M. Carvajal, H. Nicholas Marsh, Marco Gottardis, Joan Carboni, Ricardo Attar
  • GLYPICAN-3-BINDING FIBRONECTIN BASED SCAFFOLD MOLECULES
    Publication number: 20200262893
    Abstract: Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a 10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 10Fn3 drug conjugates are also provided.
    Type: Application
    Filed: January 24, 2020
    Publication date: August 20, 2020
    Inventors: Dasa LIPOVSEK, Joseph TOTH, Ginger C. RAKESTRAW, Irvith M. CARVAJAL, Stanley Richard KRYSTEK, Jr., Steven R. O'NEIL, Guodong CHEN, Richard Y. HUANG, Bryan C. BARNHART, John Thomas LOFFREDO, Christina TERRAGNI
  • Glypican-3-binding fibronectin based scaffold molecules
    Patent number: 10584160
    Abstract: Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a 10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 10Fn3 drug conjugates are also provided.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: March 10, 2020
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Dasa Lipovsek, Joseph Toth, Ginger C. Rakestraw, Irvith M. Carvajal, Stanley Richard Krystek, Jr., Steven R. O'Neil, Guodong Chen, Richard Y. Huang, Bryan C. Barnhart, John Thomas Loffredo, Christina Terragni
  • GLYPICAN-3-BINDING FIBRONECTIN BASED SCAFFOLD MOLECULES
    Publication number: 20190077844
    Abstract: Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a 10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 10Fn3 drug conjugates are also provided.
    Type: Application
    Filed: September 22, 2016
    Publication date: March 14, 2019
    Inventors: Dasa LIPOVSEK, Joseph TOTH, Ginger C. RAKESTRAW, Irvith M. CARVAJAL, Stanley Richard KRYSTEK, JR., Steven R. O'NEIL, Guodong CHEN, Richard Y. HUANG, Bryan C. BARNHART, John Thomas LOFFREDO, Christina TERRAGNI
  • MULTIVALENT FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS
    Publication number: 20180265572
    Abstract: The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
    Type: Application
    Filed: January 10, 2018
    Publication date: September 20, 2018
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Ray CAMPHAUSEN, Eric FURFINE, Irvith M. CARVAJAL, H. Nicholas MARSH, Marco GOTTARDIS, Joan CARBONI, Ricardo ATTAR
  • Multivalent fibronectin based scaffold domain proteins
    Patent number: 9902762
    Abstract: The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: February 27, 2018
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Ray Camphausen, Eric Furfine, Irvith M. Carvajal, H. Nicholas Marsh, Marco Gottardis, Joan Carboni, Ricardo Attar
  • MULTIVALENT FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS
    Publication number: 20140349929
    Abstract: The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
    Type: Application
    Filed: March 28, 2014
    Publication date: November 27, 2014
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Ray CAMPHAUSEN, Eric FURFINE, Irvith M. CARVAJAL, H. Nicholas MARSH, Marco GOTTARDIS, Joan CARBONI, Ricardo ATTAR
  • Multivalent fibronectin based scaffold domain proteins
    Patent number: 8728483
    Abstract: The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: May 20, 2014
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ray Camphausen, Eric Furfine, Irvith M. Carvajal, H. Nicholas Marsh, Marco Gottardis, Joan Carboni, Ricardo Attar
  • MULTIVALENT FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS
    Publication number: 20130012435
    Abstract: The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
    Type: Application
    Filed: June 26, 2012
    Publication date: January 10, 2013
    Applicant: Bristol-Myers Squibb Company
    Inventors: Ray Camphausen, Eric Furfine, Irvith M. Carvajal, H. Nicholas Marsh, Marco Gottardis, Joan Carboni, Ricardo Attar
  • Multivalent fibronectin based scaffold domain proteins
    Patent number: 8221765
    Abstract: The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: July 17, 2012
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ray Camphausen, Eric Furfine, Irvith M. Carvajal, H. Nicholas Marsh, Marco Gottardis, Joan Carboni, Ricardo Attar
  • COMBINATION OF VEGFR2 AND IGF1R INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
    Publication number: 20110123545
    Abstract: Methods for increasing endothelial cell apoptosis under hypoxic conditions in a patient undergoing a treatment that comprises an IGF1R inhibitor, the method comprising administering to the patient a VEGFR2 inhibitor
    Type: Application
    Filed: November 24, 2010
    Publication date: May 26, 2011
    Inventors: H. Nicholas Marsh, Irvith M. Carvajal, Marco M. Gottardis, Joan M. Carboni, Bryan C. Barnhart, Ricardo M. Attar
  • COMBINATION VEGFR2 THERAPY WITH mTOR INHIBITORS
    Publication number: 20110034384
    Abstract: The present disclosure relates to improved methods of treating neoplastic disorders by combining VEGFR2 specific inhibitor treatment with mTOR inhibitors. The present disclosure also relates to methods of preventing the development of VEGFR2 resistance.
    Type: Application
    Filed: November 24, 2008
    Publication date: February 10, 2011
    Applicant: Bristol-Myers Squibb Company
    Inventor: Irvith M. Carvajal
  • Combination VEGFR2 Therapy with Temozolomide
    Publication number: 20100210511
    Abstract: The present disclosure relates to improved methods of treating neoplastic disorders by combining VEGFR2 specific inhibitor treatment with temozolomide. In particular, methods for treating glioblastoma with a combination of a VEGFR2 inhibitor and temozolomide are provided.
    Type: Application
    Filed: February 11, 2010
    Publication date: August 19, 2010
    Applicant: Bristol-Myers Squibb Company
    Inventor: Irvith M. Carvajal
  • MULTIVALENT FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS
    Publication number: 20090299040
    Abstract: The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.
    Type: Application
    Filed: May 22, 2009
    Publication date: December 3, 2009
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: RAY CAMPHAUSEN, ERIC FURFINE, IRVITH M. CARVAJAL, H. NICHOLAS MARSH, MARCO GOTTARDIS, JOAN CARBONI, RICARDO ATTAR