Patents by Inventor Isaac ADJEI

Isaac ADJEI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11179416
    Abstract: The present disclosure relates to manganese dioxide nanoparticles and their use in treatment of oxidative stress and conditions related to or characterized by oxidative stress, including osteoarthritis.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: November 23, 2021
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Blanka Sharma, Isaac Adjei, Shreedevi Kumar
  • Publication number: 20200390807
    Abstract: The present invention provides manganese dioxide nanoparticles complexed with one or more nucleic acid sequences for introduction into NK cells for an immunotherapy treatment. The nanoparticles discussed herein target and silence TGF-? in order to reactivate NK cells that have been inactivated or suppressed. Provided is a method of inducing an anti-cancer immune response in a subject, comprising administering to immune cells of the subject a pharmaceutically effective amount of a nanoparticle composition comprising a manganese dioxide nanoparticle complexed with a nucleic acid sequence in an amount sufficient to induce, enhance, or promote an immune response against the cancer in the subject. The invention also comprises a manganese dioxide nanoparticle formulation, comprising the manganese dioxide nanoparticle(s) as described and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: February 20, 2019
    Publication date: December 17, 2020
    Inventors: Isaac ADJEI, Blanka SHARMA
  • Publication number: 20200390806
    Abstract: The present disclosure relates to manganese dioxide nanoparticles and their use in treatment of oxidative stress and conditions related to or characterized by oxidative stress, including osteoarthritis.
    Type: Application
    Filed: February 20, 2019
    Publication date: December 17, 2020
    Inventors: Blanka SHARMA, Isaac ADJEI, Shreedevi KUMAR