Patents by Inventor Isao Hara

Isao Hara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160299023
    Abstract: Provided is a pressure transmitter device including: a pressure receiving diaphragm in contact with a measuring fluid; a fill fluid, in contact with an opposite side of the pressure receiving diaphragm to the other side in contact with the measuring fluid, for transferring a pressure received by the pressure receiving diaphragm from the measuring fluid to a sensor disposed at a position apart from the pressure receiving diaphragm; a hydraulic path filled with the fill fluid and connecting the pressure receiving diaphragm and the sensor; and an output circuit for measuring and outputting an absolute pressure of the measuring fluid or a differential pressure between measuring fluids based on the pressure received by the sensor, where a hydrocarbon absorbing material for absorbing hydrocarbon and a hydrogen occlusion material for occluding hydrogen are provided inside the hydraulic path.
    Type: Application
    Filed: March 21, 2016
    Publication date: October 13, 2016
    Inventors: Ryo KUWANA, Daisuke SHINMA, Atsushi FUSHIMI, Hideki HANAMI, Isao HARA
  • Patent number: 9370589
    Abstract: The present invention provides a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye during nanoparticle preparation, and emit fluorescence during imaging). A switching fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the molecular assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a cyanine compound represented by the formula (I): and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: June 21, 2016
    Assignees: SHIMADZU CORPORATION, KYOTO UNIVERSITY
    Inventors: Isao Hara, Eiichi Ozeki, Hideo Saji, Shunsaku Kimura, Masahiro Ono, Takashi Temma
  • Publication number: 20160001278
    Abstract: The objectives of the present invention are to provide an olefin oligomerization catalyst that allows properties of particles of a polymer component by-produced in an ?-olefin production process to be obtained in such a shape that does not negatively affect a separation process for the particles and to provide a method for producing an olefin oligomer performed in the presence of the olefin oligomerization catalyst. The objectives can be achieved by the olefin oligomerization catalyst obtained by contacting (D) a transition metal compound with a preliminary contact solid catalyst component (II) obtained by contacting a solid catalyst component (I) formed by supporting (B) an organoaluminum oxy-compound (b-2) on (A) a solid carrier with (C) at least one compound selected from the group consisting of an organometallic compound (c-1), an organoaluminum oxy-compound (c-2), and a compound (c-3) that reacts with the transition metal compound (D) to form a pair of ion.
    Type: Application
    Filed: February 26, 2014
    Publication date: January 7, 2016
    Applicant: MITSUI CHEMICALS, INC.
    Inventors: Yasunori SAITO, Atsushi SHIBAHARA, Isao HARA, Kazumori KAWAMURA
  • Publication number: 20150376306
    Abstract: An object of the invention is to provide a solid polyaluminoxane composition suitably used as a cocatalyst and a catalyst carrier in combination with an olefin oligomerization or polymerization catalyst, without the use of solid inorganic carriers such as silica. The solid polyaluminoxane composition of the invention includes a polyalkylaluminoxane and a trialkylaluminum, and has a solubility in n-hexane at 25° C. of less than 0.50 mol % as measured by a specific method (i), a solubility in toluene at 25° C. of less than 1.0 mol % as measured by a specific method (ii), and a 13 mol % or more molar fraction of alkyl groups derived from the trialkylaluminum moieties relative to the total number of moles of alkyl groups derived from the polyalkylaluminoxane moieties and the alkyl groups derived from the trialkylaluminum moieties as measured with respect to tetrahydrofuran-d8 soluble components by a specific method (iii).
    Type: Application
    Filed: February 7, 2014
    Publication date: December 31, 2015
    Applicant: Mitsui Chemicals, Inc.
    Inventors: Kou TSURUGI, Siori HANADA, Atsushi SHIBAHARA, Kazumori KAWAMURA, Fumiaki NISHINO, Yasuyuki HARADA, Wataru YAMADA, Akiko MATSUMOTO, Isao HARA, Tatsuya NAKAMURA, Toshihiro MUROTO
  • Patent number: 9140620
    Abstract: Hydrogen which has entered into a pressure/differential pressure transmitter from external or internally generated hydrogen and hydrocarbons are converted to air bubbles within pressure guide paths. As a result, the indicated value drifts and an accurate numerical value is not output. A pressure/differential pressure transmitter includes a space formed between a diaphragm and a main body side wall face, pressure guide paths connected to the main body side wall face, a sealed liquid sealed in the space and the pressure guide paths to transmit a pressure received by the diaphragm to a sensor, and a hydrogen absorption material provided at least in the sealed liquid, on the main body side wall face, or in a part of a path between the main body side wall face and the sensor to absorb hydrogen atoms in the sealed liquid.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: September 22, 2015
    Assignee: HITACHI, LTD.
    Inventors: Ryo Kuwana, Atsushi Baba, Atsushi Fushimi, Daisuke Shinma, Hideki Hanami, Isao Hara, Takashi Ito
  • Publication number: 20150228365
    Abstract: The present invention provides instrumentation equipment for a nuclear power plant in which the formation of bubbles in an impulse line can be surely inhibited and thereby reliability and maintainability are improved for a long period of time. Instrumentation equipment for a nuclear power plant including: a tubular impulse line provided on a site to measure a fluid to be measured in a primary system of a nuclear power plant; a sealed liquid filled within the impulse line; a pressure-sensing diaphragm provided in a state of closing one opening of the impulse line to receive a pressure of the fluid to be measured; a pressure sensor provided on another opening of the impulse line in a state of being exposed to the sealed liquid; and a hydrogen storage material provided within the impulse line.
    Type: Application
    Filed: February 11, 2015
    Publication date: August 13, 2015
    Inventors: Setsuo Arita, Ryo Kuwana, Atsushi Baba, Atsushi Fushimi, Daisuke Shinma, Hideki Hanami, Isao Hara, Takashi Ito
  • Publication number: 20150202327
    Abstract: The present invention provides a molecular assembly whose retention time in a target site is adjusted depending on the kind or purpose of a labeling agent or drug encapsulated therein, and a molecular assembly that can suppress the ABC phenomenon and that can be administered more than once within a short span.
    Type: Application
    Filed: September 3, 2013
    Publication date: July 23, 2015
    Applicant: KYOTO UNIVERSITY
    Inventors: Isao Hara, Eiichi Ozeki, Shunsaku Kimura, Akira Makino
  • Publication number: 20150135842
    Abstract: In a pressure and pressure difference transmitter that seals a sealing liquid for transmitting the pressure inside a pressure leading passage, the pressure and pressure difference transmitter forming a space between a diaphragm and a main body side wall surface, including the pressure leading passage connected to the main body side wall surface, and transmitting the pressure received by the diaphragm to a sensor through the sealing liquid sealed in the space and the pressure leading passage, a hydrogen occluding material for occluding hydrogen atoms of the sealing liquid is disposed at least in the sealing liquid, the main body side wall surface, or a part of a portion from the main body side wall surface to the sensor, with the hydrogen occluding material being formed with an uneven shape on the surface or being attached with a granular hydrogen occluding material.
    Type: Application
    Filed: November 4, 2014
    Publication date: May 21, 2015
    Inventors: Ryo KUWANA, Atsushi FUSHIMI, Daisuke SHINMA, Hideki HANAMI, Isao HARA
  • Publication number: 20150107364
    Abstract: A pressure transmitter including tube-like pressure introducing pipes, a sealed-in liquid, the inside of the pressure introducing pipes being filled with the sealed-in liquid, pressure receiving diaphragms for receiving the pressures of measurement fluids, the pressure receiving diaphragms being set up in a state where one-side apertures in the pressure introducing pipes are blocked by the pressure receiving diaphragms, a pressure sensor that is set up in common to the other-side apertures in the pressure introducing pipes in a state where the pressure sensor is exposed to the sealed-in liquid, and hydrogen-permeation prevention layers that are set up on the pressure receiving diaphragms, wherein the pressure transmitter further includes a hydrogen-storage material that is set up inside the pressure introducing pipes.
    Type: Application
    Filed: October 16, 2014
    Publication date: April 23, 2015
    Inventors: Ryo KUWANA, Setsuo ARITA, Atsushi BABA, Atsushi FUSHIMI, Daisuke SHINMA, Hideki HANAMI, Isao HARA, Takashi ITOU
  • Publication number: 20150107365
    Abstract: A pressure transmitter including tube-like pressure introducing pipes, a sealed-in liquid, the inside of the pressure introducing pipes being filled with the sealed-in liquid, pressure receiving diaphragms for receiving the pressures of measurement fluids, the pressure receiving diaphragms being set up in a state where one-side apertures in the pressure introducing pipes are blocked by the pressure receiving diaphragms, and a pressure sensor that is set up in common to the other-side apertures in the pressure introducing pipes in a state where the pressure sensor is exposed to the sealed-in liquid, wherein the sealed-in liquid is silicon oil containing phenyl groups, the pressure transmitter further including a hydrogen-storage material that is set up inside the pressure introducing pipes.
    Type: Application
    Filed: October 16, 2014
    Publication date: April 23, 2015
    Inventors: Setsuo ARITA, Ryo KUWANA, Atsushi BABA, Atsushi FUSHIMI, Daisuke SHINMA, Hideki HANAMI, Isao HARA, Takashi ITOU
  • Publication number: 20150031988
    Abstract: The present invention provides a therapeutic system that is widely applicable to general solid cancers, can achieve both a reduction in side effects of cancer therapy and suppression of cancer recurrence and metastasis, and requires no expensive drug such as an antibody; and a nanoparticle for internal radiation therapy. A system for internal radiation therapy of a vascular lesion site comprising: a device comprising a means for acquiring image data showing a position of a vascular lesion site, and a means for positioning a needle, which should be punctured into the vascular lesion site, at the vascular lesion site based on the image data; and a nanoparticle comprising an amphiphilic block polymer comprising a hydrophilic block having a sarcosine unit and a hydrophobic block having a lactic acid unit, and a substance labeled with a ?-ray emitting nuclide. The nanoparticle for internal radiation therapy.
    Type: Application
    Filed: September 12, 2012
    Publication date: January 29, 2015
    Inventors: Eri Takeuchi, Isao Hara, Ryo Yamahara, Eiichi Ozeki, Shunsaku Kimura, Kensuke Kurihara
  • Patent number: 8809490
    Abstract: A method for producing a solution containing at least an unsaturated carboxylic acid-modified vinyl alcohol polymer is characterized by reacting a vinyl alcohol polymer and an unsaturated carboxylic acid compound in the presence of an acid catalyst soluble in the reaction system or a solid acid catalyst, and a gas barrier film is obtained by using the same. An example thereof is a method for producing a solution (A) containing an unsaturated carboxylic acid-modified vinyl alcohol polymer (b), the method comprising following two steps of: (1) a reaction step in which the unsaturated carboxylic acid-modified vinyl alcohol polymer (b) is formed by reacting a vinyl alcohol polymer and an unsaturated carboxylic acid compound (a) in the presence of an acid catalyst soluble in the reaction system; and (2) an ion exchange step in which at least the acid catalyst of acidic compounds is removed by an anion exchange resin.
    Type: Grant
    Filed: May 31, 2007
    Date of Patent: August 19, 2014
    Assignee: Tohcello Co., Ltd.
    Inventors: Kou Tsurugi, Yoshihisa Inoue, Isao Hara, Hiroyoshi Watanabe, Tomoyoshi Hakamata, Akira Nomoto, Osamu Nakamura
  • Publication number: 20140096613
    Abstract: Hydrogen which has entered into a pressure/differential pressure transmitter from external or internally generated hydrogen and hydrocarbons are converted to air bubbles within pressure guide paths. As a result, the indicated value drifts and an accurate numerical value is not output. A pressure/differential pressure transmitter includes a space formed between a diaphragm and a main body side wall face, pressure guide paths connected to the main body side wall face, a sealed liquid sealed in the space and the pressure guide paths to transmit a pressure received by the diaphragm to a sensor, and a hydrogen absorption material provided at least in the sealed liquid, on the main body side wall face, or in a part of a path between the main body side wall face and the sensor to absorb hydrogen atoms in the sealed liquid.
    Type: Application
    Filed: September 12, 2013
    Publication date: April 10, 2014
    Applicant: HITACHI, LTD.
    Inventors: Ryo KUWANA, Atsushi BABA, Atsushi FUSHIMI, Daisuke SHINMA, Hideki HANAMI, Isao HARA, TAKASHI ITO
  • Publication number: 20130336896
    Abstract: [Problem] To provide a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye in a blood component and emit fluorescence in a tumor or an inflamed site to be imaged).
    Type: Application
    Filed: March 1, 2012
    Publication date: December 19, 2013
    Inventors: Hideo Saji, Shunsaku Kimura, Masahiro Ono, Takashi Temma, Isao Hara, Eiichi Ozeki
  • Publication number: 20130149252
    Abstract: The present invention provides a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye during nanoparticle preparation, and emit fluorescence during imaging). A switching fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the molecular assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a cyanine compound represented by the formula (I): and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.
    Type: Application
    Filed: August 8, 2011
    Publication date: June 13, 2013
    Inventors: Isao Hara, Eiichi Ozeki, Hideo Saji, Shunsaku Kimura, Masahiro Ono, Takashi Temma
  • Publication number: 20120255353
    Abstract: To achieve a fluid level measurement instrument requiring no detecting pipe that can accurately measure over a long period of time a fluid level in a tank for storing therein fluid without having to use a detecting pipe for sampling the fluid from the tank. A balance tube 41 has no detecting pipes and a solenoid coil 45 is wound around an outside of the balance tube 41. A float 46 containing therein a magnetic material 47 is disposed inside the solenoid coil 45. A cover 59 formed, for example, of metal covers an outer surface of the float 46 to prevent entry of fluid and hydrogen from outside. The float 46 moves according to a fluid level in the balance tube 41, which results also in inductance of the solenoid coil 45 being changed. Measuring the inductance of the solenoid coil 45 allows the fluid level of the balance tube 41 to be measured without having to use the detecting pipe.
    Type: Application
    Filed: April 3, 2012
    Publication date: October 11, 2012
    Applicant: Hitachi, Ltd.
    Inventors: Tatsuro Kozaki, Hiroshi Yatabe, Isao Hara, Toshiro Akahira
  • Patent number: 8258361
    Abstract: The invention provides transition metal complex compounds, high-activity olefin oligomerization catalysts containing the compounds, and olefin oligomerization processes using the catalysts. A transition metal complex compound [A] according to the invention is represented by Formula (I) or Formula (I?) below. An olefin oligomerization catalyst includes the transition metal complex compound [A]. In an olefin oligomerization process of the invention, an olefin is oligomerized in the presence of the catalyst.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: September 4, 2012
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Yasuhiko Suzuki, Shinsuke Kinoshita, Atsushi Shibahara, Naritoshi Yoshimura, Isao Hara, Tetsuya Hamada, Kazumori Kawamura, Kou Tsurugi, Yasunori Saito, Seiichi Ishii, Yasushi Nakayama, Naoto Matsukawa, Susumu Murata
  • Publication number: 20110288240
    Abstract: A phosphazene-supported catalyst in which a support is bonded to a group represented by the general formula (1): wherein n, Zn?, a, b, c, d, R, R1 and D are all defined. The phosphazene-supported catalyst is highly effective to catalyze various organic reactions, and further has no reduction of activity even after recovery and reuse of the catalyst, thus it being economically advantageous. In addition, the polymerization of cyclic monomers, substitution of substituents, carbon-carbon bond forming reactions and the like can be conducted with extremely high efficiency.
    Type: Application
    Filed: August 4, 2011
    Publication date: November 24, 2011
    Applicant: Mitsui Chemicals, Inc.
    Inventors: Naritoshi YOSHIMURA, Shinji Kiyono, Kazumi Mizutani, Isao Hara, Takaomi Hayashi, Tadahito Nobori, Yoshihiro Yamamoto, Miyuki Konno, Yoshihisa Inoue, Akira Matsuura, Tuneyuki Ohkubo
  • Publication number: 20110104056
    Abstract: The present invention provides a molecular assembly which is less likely to accumulate in tissue other than cancer tissue, is highly safe for a living body, and can be prepared by a simple and safe method and whose particle size can be easily controlled. The present invention provides a molecular imaging system and a molecular probe useful for the system, and a drug delivery system and a molecular probe useful for the system. The present invention provides a method for preparing molecular assembly, by which the particle size of molecular assembly having a signal group or a drug can be arbitrarily controlled in order to allow the molecular assembly to effectively accumulate in cancer tissue by utilizing EPR effect.
    Type: Application
    Filed: June 4, 2009
    Publication date: May 5, 2011
    Inventors: Isao Hara, Ryo Yamahara, Eiichi Ozeki, Eri Takeuchi, Shunsaku Kimura, Shinae Kondoh, Akira Makino, Fumihiko Yamamoto
  • Publication number: 20110082325
    Abstract: The invention provides transition metal complex compounds, high-activity olefin oligomerization catalysts containing the compounds, and olefin oligomerization processes using the catalysts. A transition metal complex compound [A] according to the invention is represented by Formula (I) or Formula (I?) below. An olefin oligomerization catalyst includes the transition metal complex compound [A]. In an olefin oligomerization process of the invention, an olefin is oligomerized in the presence of the catalyst.
    Type: Application
    Filed: June 27, 2008
    Publication date: April 7, 2011
    Inventors: Yasuhiko Suzuki, Shinsuke Kinoshita, Atsushi Shibahara, Naritoshi Yoshimura, Isao Hara, Tetsuya Hamada, Kazumori Kawamura, Kou Tsurugi, Yasunori Saito, Seiichi Ishii, Yasushi Nakayama, Naoto Matsukawa, Susumu Murata