Patents by Inventor Isao Yamatsu
Isao Yamatsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6288128Abstract: A &bgr;,&ggr;-dihydropolyprenyl alcohol derivative having the formula: wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group, is new and useful as a prophylactic therapeutic agent for human and animal immuno-deficiency deseases and phylactic agent against human and animal infectious deseases. Another disclosed polyprenyl compound is also useful as the same agent.Type: GrantFiled: February 14, 1996Date of Patent: September 11, 2001Assignee: Eisai Co., Ltd.Inventors: Masaichi Yamamoto, Seiichi Araki, Hiroshi Yamamoto, Isao Yamatsu, Takeshi Suzuki, Akiharu Kajiwara, Yoshikazu Suzuki, Haruyoshi Arai
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Patent number: 6111131Abstract: A .beta.,.gamma.-dihydropolyprenyl alcohol derivative having the formula: ##STR1## wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group, is new and useful as a prophylactic therapeutic agent for human and animal immuno-deficiency deseases and phylactic agent against human and animal infectious deseases. Another disclosed polyprenyl compound is also useful as the same agent.Type: GrantFiled: January 11, 1996Date of Patent: August 29, 2000Assignee: Eisai Co., Ltd.Inventors: Masaichi Yamamoto, Seiichi Araki, Hiroshi Yamamoto, Isao Yamatsu, Takeshi Suzuki, Akiharu Kajiwara, Yoshikazu Suzuki, Haruyoshi Arai
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Patent number: 5854279Abstract: The present invention provides a therapeutic agent for fundamentally preventing, treating or ameliorating dermatosis, such as, non-infectious dermatosis, which include psoriasis and atopic dermatitis. The therapeutic agent comprises a glycerol derivative represented by the formula (I): ##STR1## wherein A is a group represented by the formula: ##STR2## or single bond; R.sup.1 is a group represented by the formula: ##STR3## wherein R.sup.2 is a methoxyphenyl group or methyl group, X is an atom or atomic group which may become an anionor a group represented by the formula: ##STR4## or a pharmacologically acceptable salt thereof as an active ingredient.Type: GrantFiled: May 1, 1997Date of Patent: December 29, 1998Assignee: Eisai Co., LtdInventors: Akiko Nakahama, Koukichi Harada, Toshihiko Yamauchi, Takashi Yamanaka, Isao Yamatsu
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Patent number: 5789446Abstract: To provide a treating or ameliorating agent for joint diseases accompanied with arthritis, preferably, a rheumatoid arthritis or ameliorating agent, which exerts excellent pharmaceutical effects. The active ingredient is a quinone derivative represented by the following general formula (I) or pharmacologically acceptable salts thereof: ##STR1## wherein n is 0 or an integer of 1 to 12 and R is a methyl or methoxy group.Type: GrantFiled: June 17, 1997Date of Patent: August 4, 1998Assignee: Eisai Co., Ltd.Inventors: Akiyoshi Uchiyama, Kenzo Muramoto, Kenichi Chiba, Takashi Yamanaka, Isao Yamatsu
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Patent number: 5658958Abstract: Various .beta.,.gamma.-dihydropolyprenyl alcohol derivatives having the formula: ##STR1## wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group are effective at pritigating stress in animals.Type: GrantFiled: February 14, 1996Date of Patent: August 19, 1997Assignee: Eisai Co., Ltd.Inventors: Masaichi Yamamoto, Seiichi Araki, Hiroshi Yamamoto, Isao Yamatsu, Takeshi Suzuki, Akiharu Kajiwara, Yoshikazu Suzuki, Haruyoshi Arai
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Patent number: 5635519Abstract: A benzothiazole derivative or a pharmacologically acceptable salt thereof of the following formula, as defined in the claims, which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective: ##STR1##Type: GrantFiled: February 15, 1995Date of Patent: June 3, 1997Assignee: Eisai Co., Ltd.Inventors: Yasushi Okamoto, Katsuya Tagami, Shigeki Hibi, Hirotoshi Numata, Naoki Kobayashi, Masanobu Shinoda, Tetsuya Kawahara, Manabu Murakami, Kiyoshi Oketani, Takashi Inoue, Takashi Yamanaka, Isao Yamatsu
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Patent number: 5631402Abstract: An aminobenzoic acid derivative represented by the following general formulas (I), (I-2) or (I-3), or a pharmacologically acceptable salt thereof, which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio and which is efficacious as a drug for patients with gastrointestinal unindentified complaints: ##STR1## wherein R.sup.1 represents a group such as an alkynyl or cyanoalkyl group; R.sup.2 represents a group such as an amino or acylamino group; R.sup.3 represents a halogen atom; X represents --O-- or --NH--; and A represents an oxygen or sulfur atom.Type: GrantFiled: June 7, 1995Date of Patent: May 20, 1997Assignee: Eisai Co., Ltd.Inventors: Shuhei Miyazawa, Shigeki Hibi, Hiroyuki Yoshimura, Takashi Mori, Yorihisa Hoshino, Mitsuo Nagai, Kouichi Kikuchi, Hisashi Shibata, Kazuo Hirota, Takashi Yamanaka, Isao Yamatsu, Masanori Mizuno
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Patent number: 5612356Abstract: A heterocycle-containing carbonic acid derivative represented by the following general formula (I): ##STR1## or a physiologically acceptable salt thereof which exhibits an excellent preventive and therapeutic effect against various diseases, and an intermediate which is useful for the production of the heterocycle-containing carbonic acid derivative.Type: GrantFiled: April 25, 1995Date of Patent: March 18, 1997Assignee: Eisai Co., Ltd.Inventors: Hiroyuki Yoshimura, Mitsuo Nagai, Shigeki Hibi, Koichi Kikuchi, Ieharu Hishinuma, Junichi Nagakawa, Makoto Asada, Norimasa Miyamoto, Takayuki Hida, Aichi Ogasawara, Isao Yamatsu
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Patent number: 5599972Abstract: An aminobenzoic acid derivative represented by the following general formulas (I), (I-2) or (I-3), or a pharmacologically acceptable salt thereof, which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio and which is efficacious as a drug for patients with gastrointestinal unindentified complaints: ##STR1## wherein R.sup.1 represents a group such as an alkynyl or cyanoalkyl group; R.sup.2 represents a group such as an amino or acylamino group; R.sup.3 represents a halogen atom; X represents --O-- or --NH--; and A represents an oxygen or sulfur atom.Type: GrantFiled: June 7, 1995Date of Patent: February 4, 1997Assignee: Eisai Co., Ltd.Inventors: Shuhei Miyazawa, Shigeki Hibi, Hiroyuki Yoshimura, Takashi Mori, Yorihisa Hoshino, Mitsuo Nagai, Kouichi Kikuchi, Hisashi Shibata, Kazuo Hirota, Takashi Yamanaka, Isao Yamatsu, Masanori Mizuno
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Patent number: 5578603Abstract: An aminobenzoic acid derivative represented by the following formulas (I-2) or (I-3), or a pharmacologically acceptable salt thereof, which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio and which is efficacious as a drug for patients with gastrointestinal unindentified complaints: ##STR1## wherein R.sup.1 represents a group such as an alkynyl or cyanoalkyl group; R.sup.2 represents a group such as an amino or acylamino group; R.sup.3 represents a halogen atom; X represents --O-- or --N--; and A represents an oxygen or sulfur atom.Type: GrantFiled: November 8, 1994Date of Patent: November 26, 1996Assignee: Eisai Co., Ltd.Inventors: Shuhei Miyazawa, Shigeki Hibi, Hiroyuki Yoshimura, Takashi Mori, Yorihisa Hoshino, Mitsuo Nagai, Kouichi Kikuchi, Hisashi Shibata, Kazuo Hirota, Takashi Yamanaka, Isao Yamatsu, Masanori Mizuno
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Patent number: 5527948Abstract: Naphthalene derivatives of the formula: ##STR1## wherein R.sup.1, represents a hydrogen atom, a lower alkyl group or an acyl group; R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroaryllakyl group; R.sup.3 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxyl group, a carboxyalkyl group, an aminoalkyl group, or a cyano group; R.sup.6 is C.sub.1-6 alkyl; and m is 0 or an integer of from 1 to 2 useful in treating autoimmune diseases are disclosed.Type: GrantFiled: March 13, 1995Date of Patent: June 18, 1996Assignee: Eisai Corp. Ltd.Inventors: Makoto Okita, Hiroshi Shirota, Masayuki Tanaka, Toshihiko Kaneko, Katsuya Tagami, Shigeki Hibi, Yasushi Okamoto, Seiichiro Nomoto, Takeshi Suzuki, Kenichi Chiba, Masaki Goto, Ryoichi Hashida, Hideki Ono, Hideto Ohhara, Hideki Sakurai, Shigeru Souda, Yoshimasa Machida, Kouichi Katayama, Isao Yamatsu
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Patent number: 5482937Abstract: A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are useful in the pharmaceutical field, especially in treating allergic diseases. ##STR1## in which R.sup.1 and R.sup.2 are hydrogen or an alkyl, R.sup.3 is hydrogen or a halogen, R.sup.4 is hydrogen or an alkyl, X is --OCO--, and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.Type: GrantFiled: October 6, 1994Date of Patent: January 9, 1996Assignee: Eisai Co., Ltd.Inventors: Kazuo Okano, Shuhei Miyazawa, Richard S. J. Clark, Shinya Abe, Tetsuya Kawahara, Naoyuki Shimomura, Osamu Asano, Hiroyuki Yoshimura, Mitsuaki Miyamoto, Yoshimori Sakuma, Kenzo Muramoto, Hiroshi Obaishi, Koukichi Harada, Hajime Tsunoda, Satoshi Katayama, Kouji Yamada, Shigeru Souda, Yoshimasa Machida, Kouichi Katayama, Isao Yamatsu
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Patent number: 5476863Abstract: A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor.Type: GrantFiled: September 30, 1993Date of Patent: December 19, 1995Assignee: Eisai Co., Ltd.Inventors: Kazuo Okano, Osamu Asano, Naoyuki Shimomura, Tetsuya Kawahara, Shinya Abe, Shuhei Miyazawa, Mitsuaki Miyamoto, Hiroyuki Yoshimura, Koukichi Harada, Junsaku Nagaoka, Tsutomu Kawata, Tsutomu Yoshimura, Hiromasa Suzuki, Shigeru Souda, Yoshimasa Machida, Kouichi Katayama, Isao Yamatsu
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Patent number: 5476864Abstract: A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor.Type: GrantFiled: November 10, 1993Date of Patent: December 19, 1995Assignee: Eisai Co., Ltd.Inventors: Kazuo Okano, Osamu Asano, Naoyuki Shimomura, Tetsuya Kawahara, Shinya Abe, Shuhei Miyazawa, Mitsuaki Miyamoto, Hiroyuki Yoshimura, Koukichi Harada, Junsaku Nagaoka, Tsutomu Kawata, Tsutomu Yoshimura, Hiromasa Suzuki, Shigeru Souda, Yoshimasa Machida, Kouichi Katayama, Isao Yamatsu
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Patent number: 5468740Abstract: A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R.sup.1 and R.sup.2 are hydrogen or an alkyl, R.sup.3 is hydrogen or a halogen, R.sup.4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.Type: GrantFiled: February 10, 1995Date of Patent: November 21, 1995Assignee: Eisai Co., Ltd.Inventors: Kazuo Okano, Shuhei Miyazawa, Richard S. J. Clark, Shinya Abe, Tetsuya Kawahara, Naoyuki Shimomura, Osamu Asano, Hiroyuki Yoshimura, Mitsuaki Miyamoto, Yoshimori Sakuma, Kenzo Muramoto, Hiroshi Obaishi, Koukichi Harada, Hajime Tsunoda, Satoshi Katayama, Kouji Yamada, Shigeru Souda, Yoshimasa Machida, Kouichi Katayama, Isao Yamatsu
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Patent number: 5438045Abstract: A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is --OOO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.Type: GrantFiled: April 27, 1993Date of Patent: August 1, 1995Assignee: Eisai Co., Ltd.Inventors: Kazuo Okano, Shuhei Miyazawa, Richard S. J. Clark, Shinya Abe, Tetsuya Kawahara, Naoyuki Shimomura, Osamu Asano, Hiroyuki Yoshimura, Mitsuaki Miyamoto, Yoshimori Sakuma, Kenzo Muramoto, Hiroshi Obaishi, Koukichi Harada, Hajime Tsunoda, Satoshi Katayama, Kouji Yamada, Shigeru Souda, Yoshimasa Machida, Kouichi Katayama, Isao Yamatsu
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Patent number: 5420144Abstract: A benzothiazole derivative or a pharmacologically acceptable salt thereof which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective.Type: GrantFiled: November 5, 1993Date of Patent: May 30, 1995Assignee: Eisai Co., Ltd.Inventors: Yasushi Okamoto, Katsuya Tagami, Shigeki Hibi, Hirotoshi Numata, Naoki Kobayashi, Masanobu Shinoda, Tetsuya Kawahara, Manabu Murakami, Kiyoshi Oketani, Takashi Inoue, Takashi Yamanaka, Isao Yamatsu
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Patent number: 5409909Abstract: A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to treat allergic diseases: ##STR1## in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.Type: GrantFiled: March 18, 1994Date of Patent: April 25, 1995Assignee: Eisai Co., Ltd.Inventors: Kazuo Okano, Shuhei Miyazawa, Richard S. J. Clark, Shinya Abe, Tetsuya Kawahara, Naoyuki Kimomura, Osamu Asano, Hiroyuki Yoshimura, Mitsuaki Miyamoto, Yoshimori Sakuma, Kenzo Muramoto, Hiroshi Obaishi, Koukichi Harada, Hajime Tsunoda, Satoshi Katayama, Kouji Yamada, Shigeru Souda, Yoshimasa Machida, Kouichi Katayama, Isao Yamatsu
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Patent number: 5389643Abstract: An aminobenzoic acid derivative represented by the following general formulas (I), (I-2) or (I-3), or a pharmacologically acceptable salt thereof, which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio and which is efficacious as a drug for patients with gastrointestinal unindentified complaints: ##STR1## wherein R.sup.1 represents a group such as an alkynyl or cyanoalkyl group; R.sup.2 represents a group such as an amino or acylamino group;R.sup.3 represents a halogen atom;X represents --O-- or --NH--; andA represents an oxygen or sulfur atom.Type: GrantFiled: February 3, 1993Date of Patent: February 14, 1995Assignee: Eisai Co., Ltd.Inventors: Shuhei Miyazawa, Shigeki Hibi, Hiroyuki Yoshimura, Takashi Mori, Yorihisa Hoshino, Mitsuo Nagai, Kouichi Kikuchi, Hisashi Shibata, Kazuo Hirota, Takashi Yamanaka, Isao Yamatsu, Masanori Mizuno
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Patent number: 5385942Abstract: A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: ##STR1## where X and Y may be the same or different from each other and are each a hydroxyl group, a group represented by the formula --(--OCH.sub.2 --).sub.n --OR.sup.6, wherein n is 0 or 1 and R.sup.6 is a lower alkyl group, or an acyl group.Type: GrantFiled: March 1, 1993Date of Patent: January 31, 1995Assignee: Eisai Co., Ltd.Inventors: Shinya Abe, Yasushi Okamoto, Katsuya Tagami, Shigeki Hibi, Junichi Nagakawa, Kazuo Hirota, Ieharu Hishinuma, Kaname Miyamoto, Takashi Yamanaka, Hiromitsu Yokohama, Tsutomu Yoshimura, Tohru Horie, Yasunori Akita, Koichi Katayama, Isao Yamatsu