Patents by Inventor Italo Raffaele

Italo Raffaele has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and apparatus for automatically determining the dilution curve of a solution, particularly the oxygen dissociation curve of blood or hemoglobin solutions
    Patent number: 4097921
    Abstract: The invention relates to an apparatus for automatically determining the oxygen dissociation curve (ODC) of whole blood or of a hemoglobin solution. Blood or hemoglobin having a predetermined oxygen saturation level are admixed with deoxygenated blood or a hemoglobin solution and the oxygen partial pressure of the mixture, while being formed, is measured. The output of the P.sub.O.sbsb.2 electrode, in the form of an electrical signal, is fed into a computer and two functions of the P.sub.O.sbsb.2 (saturation and total oxygen) are calculated, giving the required curve by means of recording and/or displaying means. In this way, the ODC can be determined for whole blood under near physiological conditions of pH, hemoglobin concentration, hematocrit, temperature, P.sub.CO.sbsb.2, and organic phosphates content.
    Type: Grant
    Filed: November 24, 1976
    Date of Patent: June 27, 1978
    Assignee: Luigi Rossi
    Inventor: Italo Raffaele
  • Analyzer for the determination of hemoglobin and other related compounds in whole blood and hemoglobin solutions
    Patent number: 4013417
    Abstract: This specification describes a new analyzer for the determination of total hemoglobin; percent oxyhemoglobin, deoxyhemoglobin, methmoglobin, sulfhemoglobin; and oxygen capacity in a micro sample (5 to 10 .mu.l) of hole human blood. The essential components of the analyzer are (1) a cuvette in which simultaneous measurements of PO.sub.2 (by an oxygen electrode) and absorbance (by a dual wavelength optical system) are made, (2) an automatic pump system for filling and emptying the cuvette, (3) an equilibrating tonometer to equilibrate the reagent with air or another gas phase, (4) electronic circuits for the measurement of light intensity and oxygen pressure, (5) an analogue computer, and (6) a printer. Other essential parts of the invention are (a) original procedures and (b) ad hoc developed physico-chemical equations.
    Type: Grant
    Filed: July 31, 1975
    Date of Patent: March 22, 1977
    Assignee: Biomedix A.G.
    Inventor: Italo Raffaele
  • Blood equilibrator
    Patent number: 3973915
    Abstract: Equilibrator device for use in determination of the acid-base status, the oxygen dissociation curve of blood and other properties of physiological interest. The device comprises, within a confined and thermostatically controlled environment, a cuvette for accommodating a sample of blood or other liquid to be equilibrated with a gas phase, means for controlledly rotating such cuvette and means for promoting passage of a gaseous flow firstly through a humidifying ambient and then into the presence of said sample.
    Type: Grant
    Filed: August 14, 1974
    Date of Patent: August 10, 1976
    Assignee: Instrumentation Laboratory, Inc.
    Inventors: Italo Raffaele, Luigi Rossi