Patents by Inventor Iwao Ojima

Iwao Ojima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11040947
    Abstract: A compound of Formula I: wherein: Y is —C(O)NHR1 or —NHC(O)R1; R1 is aryl; ?is ?optionally substituted with one or more substituents selected from the group consisting of oxo, F, Cl, Br, I, alkyl, NH2, NHR4, NHC(O)R4, NHC(O)OR4, NR5R6, OH, OR4, SR4, cycloalkyl and aryl; or ?is ?optionally substituted with one or more substituents selected from the group consisting of F, Cl, Br, I, CN, NO2, alkyl, C(O)R4, C(O)NHR4, C(O)NR5R6, C(O)OH, C(O)OR4, NH2, NHR4, NHC(O)OR4, NR5R6, OH, OR4, SR4, cycloalkyl and aryl; each R4 is independently alkyl, cycloalkyl, or aryl; each R5 is independently alkyl, cycloalkyl, or aryl; each R6 is independently alkyl, cycloalkyl, or aryl; or each R5 and R6, together with the nitrogen atom to which they are attached, independently form an unsubstituted heterocyclic alkyl or unsubstituted heterocyclic aryl; and X is —S— or —O—; and n is 2, 3, or 4.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: June 22, 2021
    Assignee: The Research Foundation for The State University of New York
    Inventors: Iwao Ojima, Vincent Alford, Anushree Kamath, Jian Cao, Xiadong Ren, Nicole Sampson, Monaf Awwa
  • Publication number: 20210179535
    Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure: Formula (I)
    Type: Application
    Filed: February 11, 2021
    Publication date: June 17, 2021
    Applicant: The Research Foundation for The State University of New York
    Inventors: Iwao Ojima, Dale Deutsch, Martin Kaczocha, Kongzhen Hu, Simon Tong, Matthew Elmes, Su Yan
  • Patent number: 11026910
    Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure:
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: June 8, 2021
    Assignee: The Research Foundation for The State University of New York
    Inventors: Iwao Ojima, Dale Deutsch, Martin Kaczocha, William T. Berger, Robert Rizzo, Trent E. Balius
  • Patent number: 10968163
    Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure: Formula (I).
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: April 6, 2021
    Assignee: The Research Foundation for the State University of New York
    Inventors: Iwao Ojima, Dale Deutsch, Martin Kaczocha, Kongzhen Hu, Simon Tong, Matthew Elmes, Su Yan
  • Publication number: 20200207705
    Abstract: The present invention provides a compound having the structure: and use of the compound for inhibiting the growth of or killing
    Type: Application
    Filed: June 15, 2018
    Publication date: July 2, 2020
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Iwao Ojima, Maurizio Del Poeta, Cristina Lazzarini, Krupanandan Haranahalli, Yi Sun
  • Publication number: 20200171132
    Abstract: The present invention provides a method of inhibiting the growth of a fungus comprising contacting the fungus with an effective amount of an inhibitor so as to thereby inhibit the growth of the fungus, wherein the inhibitor inhibits ceramide synthase 1 (Cer1) in the fungal cells of the fungus. The present invention also provides method of treating a subject afflicted with a fungal infection comprising administering to the subject an effective amount of an inhibitor so as to treat the subject afflicted with the fungal infection, wherein the inhibitor inhibits ceramide synthase 1 (Cer1) in the fungal cells of the fungus.
    Type: Application
    Filed: March 20, 2018
    Publication date: June 4, 2020
    Applicant: The Research Foundation for the State University of New York
    Inventors: Maurizio Del Poeta, Mansa Munshi, Krupanandan Haranahalli, Karen You, Iwao Ojima
  • Patent number: 10550093
    Abstract: The invention includes taxoid compounds represented by the formula: wherein: R1 represents a methyl group or a fluorine; R2 represents an alkyl or alkenyl group having one to six carbon atoms; or a cycloalkyl or cycloalkenyl group having three to seven ring carbon atoms; R3 represents an alkyl, alkenyl, dialkylamino, alkylamino, or alkoxy group having one to six carbon atoms; a cycloalkyl or cycloalkenyl group having three to seven ring carbon atoms; an aryl group having six to eighteen ring carbon atoms; or a heteroaryl group having three to seventeen ring carbon atoms; R4 represents hydrogen or a methyl group; and X represents hydrogen or fluorine.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: February 4, 2020
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Iwao Ojima, Changwei Wang, Xin Wang
  • Publication number: 20200017452
    Abstract: Small molecule inhibitors are claimed that selectively target the hemopexin domain of matrix metalloproteinase 9 (MMP-9) and do not inhibit the protease's catalytic functions. A method of treating cancer in a patient in need thereof with the compounds of the invention is also claimed.
    Type: Application
    Filed: March 22, 2018
    Publication date: January 16, 2020
    Inventors: Iwao OJIMA, Vincent ALFORD, Anushree KAMATH, Jian CAO, Xiadong REN, Nicole SAMPSON, Monaf AWWA
  • Publication number: 20190201365
    Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure:
    Type: Application
    Filed: February 15, 2019
    Publication date: July 4, 2019
    Applicant: The Research Foundation for The State University of New York
    Inventors: Iwao Ojima, Dale Deutsch, Martin Kaczocha, William T. Berger, Robert Rizzo, Trent E. Balius
  • Publication number: 20190183796
    Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nanoemulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC. A method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega03 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer.
    Type: Application
    Filed: December 19, 2018
    Publication date: June 20, 2019
    Applicants: TargaGenix, Inc., The Research Foundation for The State University of New York, Northeastern University
    Inventors: James E. Egan, Mansoor Amiji, Iwao Ojima
  • Patent number: 10280183
    Abstract: The present disclosure relates to a therapeutic agent of the formula: Z—C(?O)—(CH2)n-?-S—S—(CRR?)m-(CH2)p-C(?O)—NH—(CH2)q-NH—Y[NH—(CH2)r-X-T-W][NH—(CH2—CH—O)t(CH2)s-NH—V]??Formula I or a pharmaceutically acceptable salt thereof, useful for treating tumors, including cancers. Where the compound of Formula I also contains a radionuclide or an imaging agent or both, the compound of formula I is a theranostic agent useful for treating and diagnosing tumors, including cancers.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: May 7, 2019
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Iwao Ojima, Jacob Vineberg, Tao Wang
  • Publication number: 20190062261
    Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure: Formula (I)
    Type: Application
    Filed: March 10, 2017
    Publication date: February 28, 2019
    Applicant: The Research Foundation for the State University of New York
    Inventors: Iwao Ojima, Dale Deutsch, Martin Kaczocha, Kongzhen Hu, Simon Tong, Matthew Elmes, Su Yan
  • Patent number: 10213406
    Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure:
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: February 26, 2019
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Iwao Ojima, Dale Deutsch, Martin Kaczocha, William T. Berger, Robert Rizzo, Trent E. Balius
  • Patent number: 10206875
    Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: February 19, 2019
    Assignees: TargaGenix, Inc., The Research Foundation for the State University New York, Northeastern University
    Inventors: James E. Egan, Iwao Ojima, Mansoor M. Amiji, Galina Ivanovna Botchkina
  • Patent number: 10029014
    Abstract: The present disclosure relates to a dendrimer-based conjugate of the formula Vm-D-C-D?-(T-F)n, which is useful for tumor targeting drug delivery. The use of asymmetric dendrimers allow for specific targeting as well as synthetic reproducibility.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: July 24, 2018
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Iwao Ojima, Tao Wang, Yu-Han Teng
  • Publication number: 20180194744
    Abstract: The invention includes taxoid compounds represented by the formula: wherein: R1 represents a methyl group or a fluorine; R2 represents an alkyl or alkenyl group having one to six carbon atoms; or a cycloalkyl or cycloalkenyl group having three to seven ring carbon atoms; R3 represents an alkyl, alkenyl, dialkylamino, alkylamino, or alkoxy group having one to six carbon atoms; a cycloalkyl or cycloalkenyl group having three to seven ring carbon atoms; an aryl group having six to eighteen ring carbon atoms; or a heteroaryl group having three to seventeen ring carbon atoms; R4 represents hydrogen or a methyl group; and X represents hydrogen or fluorine.
    Type: Application
    Filed: July 1, 2016
    Publication date: July 12, 2018
    Inventors: Iwao OJIMA, Changwei WANG, Xin WANG
  • Publication number: 20180028442
    Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.
    Type: Application
    Filed: June 7, 2017
    Publication date: February 1, 2018
    Applicants: TargaGenix, Inc., The Research Foundation for the State University New York, Northeastern University
    Inventors: James E. EGAN, Iwao OJIMA, Mansoor M. AMIJI, Galina Ivanovna BOTCHKINA
  • Patent number: 9845296
    Abstract: The present invention relates to novel 2,5,6-benzimidazole derivatives and pharmaceutically acceptable salts thereof. Another aspect of the invention relates to methods of treating a patient infected by Mycobacterium tuberculosis by administering to the patient a 2,5,6-benzimidazole derivative or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: December 19, 2017
    Assignee: The Research Foundation for The State University of New York
    Inventors: Iwao Ojima, Divya Awasthi
  • Publication number: 20170216241
    Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure:
    Type: Application
    Filed: February 10, 2017
    Publication date: August 3, 2017
    Applicant: The Research Foundation for The State University of New York
    Inventors: Iwao Ojima, Dale Deutsch, Martin Kaczocha, William T. Berger, Robert Rizzo, Trent E. Balius
  • Publication number: 20170166591
    Abstract: The present disclosure relates to a therapeutic agent of the formula: Z—C(?O)—(CH2)n-?-S—S—(CRR?)m-(CH2)p—C(?O)—NH—(CH2)q—NH—Y[NH—(CH2)r—X-T-W][NH—(CH2—CH—O)t(CH2)s—NH—V]??Formula I or a pharmaceutically acceptable salt thereof, useful for treating tumors, including cancers. Where the compound of Formula I also contains a radionuclide or an imaging agent or both, the compound of formula I is a theranostic agent useful for treating and diagnosing tumors, including cancers.
    Type: Application
    Filed: March 18, 2015
    Publication date: June 15, 2017
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Iwao OJIMA, Jacob VINEBERG, Tao Wang