Patents by Inventor J. Brent Ratz

J. Brent Ratz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190336285
    Abstract: Devices, systems and methods are described herein a prosthesis for implantation within a lumen or body cavity and delivery systems for delivering the prosthesis to a location for implantation. A delivery system can include a plurality of components, including a flexible nose cone, multi-layer sheath, and pre-compressed shaft, which can be moveable relative to each other.
    Type: Application
    Filed: July 19, 2019
    Publication date: November 7, 2019
    Inventors: Arshad Quadri, J. Brent Ratz, Yen Liao, Julio Cesar Sanchez, Alexander H. Cooper, Glen T. Rabito, Siddharth Vad, Luca Pesce, Kevin M. Stewart, David Robert Landon
  • Patent number: 10441412
    Abstract: A vascular implant for replacing a native heart valve comprises a self expanding stent supporting a valve body having leaflets. The stent preferably comprises an anchoring structure configured to prevent the implant from passing through the valve annulus. For delivery, the implant is compacted within a delivery device and secured at one end. During delivery the implant is partially released from the delivery device, and positioning of the implant can be verified prior to full release. The implant can be at least partially resheathed and repositioned if desired.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: October 15, 2019
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: Arshad Quadri, J. Brent Ratz
  • Publication number: 20190298520
    Abstract: Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. A delivery component can have a plurality of slots that provide for desired bending of the delivery component, particularly compound bending of the delivery component that can facilitate steering of the delivery component in three dimensions.
    Type: Application
    Filed: June 20, 2019
    Publication date: October 3, 2019
    Inventors: Alexander H. Cooper, David Robert Landon, Julio Cesar Sanchez, Glen T. Rabito, J. Brent Ratz, Arshad Quadri, Kevin M. Stewart, Patrick Chow
  • Publication number: 20190262129
    Abstract: A mitral valve prosthesis includes an hourglass shaped inner frame and a bulbous outer frame. A valve body having a plurality of leaflets is positioned within an interior region of the inner frame. The leaflets are shaped to substantially conform to an interior surface of the inner frame when the leaflets are in an open position. As a result, the gap between the leaflets and the inner frame is decreased, thereby reducing the likelihood of thrombus formation. Ventricular anchors are preferably provided along a distal end of the inner frame. The anchors extend proximally for placement behind native mitral valve leaflets. A fabric skirt may extend along an inner or outer surface of the outer frame. In preferred embodiments, the fabric skirt extends distally beyond a distal end of the outer frame and is adapted for forming a seal along the mitral valve annulus.
    Type: Application
    Filed: February 26, 2019
    Publication date: August 29, 2019
    Inventors: Alexander H. Cooper, Juliet Laura Schwartz, Wendy Vo Pham, Hieu Minh Luong, Julio Cesar Sanchez, Matthew A. Peterson, J. Brent Ratz, Lisong Ai
  • Patent number: 10376363
    Abstract: Devices, systems and methods are described herein a prosthesis for implantation within a lumen or body cavity and delivery systems for delivering the prosthesis to a location for implantation. A delivery system can include a plurality of components, including a flexible nose cone, multi-layer sheath, and pre-compressed shaft, which can be moveable relative to each other.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: August 13, 2019
    Assignee: EDWARDS LIFESCIENCES CARDIAQ LLC
    Inventors: Arshad Quadri, J. Brent Ratz, Yen Liao, Julio Cesar Sanchez, Alexander H. Cooper, Glen T. Rabito, Siddharth Vad, Luca Pesce, Kevin M. Stewart, David Robert Landon
  • Patent number: 10350066
    Abstract: Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. A delivery component can have a plurality of slots that provide for desired bending of the delivery component, particularly compound bending of the delivery component that can facilitate steering of the delivery component in three dimensions.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: July 16, 2019
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: Alexander H. Cooper, David Robert Landon, Julio Cesar Sanchez, Glen T. Rabito, J. Brent Ratz, Arshad Quadri, Kevin M. Stewart, Patrick Chow
  • Publication number: 20190142585
    Abstract: A prosthesis for placement within a native mitral valve includes an expandable frame having locking tabs disposed along a proximal end. A plurality of distal anchors are disposed along a distal end of the frame. Each distal anchor is provided with a cushion cover. An outer fabric member surrounds the frame and may extend outwardly from the frame in an expanded condition for providing an improved seal in the region of a mitral annulus. A valve body is positioned within an interior of the expandable from for allowing blood flow in only one direction. In preferred embodiments, the cushions are positioned over enlarged head portions of the distal anchors for further reducing trauma on surrounding tissue.
    Type: Application
    Filed: January 14, 2019
    Publication date: May 16, 2019
    Inventors: J. Brent Ratz, Luca Pesce, Glen T. Rabito, Christine Thanh Nguyen
  • Publication number: 20190117392
    Abstract: A method of treating a diseased native valve includes advancing a replacement heart valve to native valve annulus. The heart valve includes an expandable frame and a valve body. The frame is formed with a plurality of cells and the valve body is formed with a plurality of leaflets configured to allow blood flow in a first direction. The frame is expanded from a radially compacted configuration to an expanded configuration at the native valve annulus. The replacement heart valve also includes one or more openings covered by one or more flaps and blood is allowed to flow through the openings in the first direction.
    Type: Application
    Filed: December 20, 2018
    Publication date: April 25, 2019
    Inventors: Arshad Quadri, J. Brent Ratz, Robrecht Michiels
  • Publication number: 20190069997
    Abstract: A mitral valve prosthesis includes an expandable frame having a proximal end, a distal end, and a middle portion. A plurality of tips extend from the proximal end of the frame for attachment to a delivery catheter. A plurality of anchors are disposed along the distal end of the frame and extend toward the proximal end for engaging tissue. An outer circumferential portion extends around the middle portion of the frame and is positioned radially outwardly of the frame. The outer circumferential portion preferably increases in diameter along a distal direction. A distal end of the outer circumferential portion is located distal of free ends of the anchors when the expandable frame is deployed. A valve body is positioned within an interior of the expandable frame and includes leaflets adapted to allow flow in a first direction and prevent flow in a second direction.
    Type: Application
    Filed: October 31, 2018
    Publication date: March 7, 2019
    Inventors: J. Brent Ratz, Luca Pesce, Siddharth Vad, Garrett Dallas Johnson
  • Patent number: 10179044
    Abstract: A prosthesis can be configured to grasp intralumenal tissue when deployed within a body cavity and prevent axial flow of fluid around an exterior of the prosthesis. The prosthesis can include an expandable frame configured to radially expand and contract for deployment within the body cavity, and an annular flap positioned around an exterior of the expandable frame. In some embodiments, the annular flap can extend outward from the frame and have a collapsed configuration and an expanded configuration.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: January 15, 2019
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: J. Brent Ratz, Luca Pesce, Glen T. Rabito, Christine Thanh Nguyen
  • Publication number: 20190008639
    Abstract: Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. Disclosed are a number of features that can improve steerability or release of the prosthesis into the body location.
    Type: Application
    Filed: July 5, 2018
    Publication date: January 10, 2019
    Inventors: David Robert Landon, Alexander H. Cooper, Julio Cesar Sanchez, Glen T. Rabito, Victoria Cheng-Tan Wu, Kevin M. Golemo, J. Brent Ratz, Tarannum Ishaq Gutierrez, Ramon Aguilar, JR., Taylor Jacob Scheinblum, Kevin M. Stewart, Garrett Dallas Johnson, Jesse Robert Edwards, Hieu Minh Luong, Lindsay Lam
  • Patent number: 10166097
    Abstract: A replacement heart valve has an expandable frame configured to engage a native valve annulus and a valve body mounted to the expandable frame. The valve body can have a plurality of valve leaflets configured to open to allow flow in a first direction and engage one another so as to close and prevent flow in a second direction, the second direction being opposite the first direction.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: January 1, 2019
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: Arshad Quadri, J. Brent Ratz, Robrecht Michiels
  • Patent number: 10149756
    Abstract: A heart valve includes a valve body made of a flexible material such as pericardium. The valve body is made of two layers of material, an outer layer, and an inner layer that defines a plurality of leaflets. The leaflets of the inner layer are attached to the outer layer. In some embodiments the valve body is made by cutting a single piece of flat source tissue, folding the cut tissue and forming it into a tubular pattern having the inner and outer layers. The multi-layer valve body can be mounted on a stent for delivery within a patient's heart.
    Type: Grant
    Filed: July 25, 2016
    Date of Patent: December 11, 2018
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: Arshad Quadri, J. Brent Ratz
  • Patent number: 10117744
    Abstract: A valve prosthesis can be configured to be deployed within a native heart valve and prevent axial flow of fluid around an exterior of the prosthesis. The prosthesis can include an expandable frame configured to radially expand and contract for deployment within the native heart valve, a flap assembly positioned around an exterior of the expandable frame, a proximal end of the flap assembly being positioned at or proximate a proximal end of the expandable frame. In some embodiments, the flap assembly can extend outward from the frame and have an expanded configuration configured to create a barrier to fluid flow exterior to the frame when deployed within the native heart valve.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: November 6, 2018
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: J. Brent Ratz, Luca Pesce, Siddharth Vad, Garrett Dallas Johnson
  • Publication number: 20180296338
    Abstract: Devices, systems and methods are described herein a prosthesis for implantation within a lumen or body cavity and delivery devices for delivering the prosthesis to a location for implantation. A delivery system can include a plurality of components which are moveable relative to each other. The delivery system can include a nose cone which can cover at least a first end of the prosthesis, an outer elongate member which can cover at least a second end of the prosthesis, and a tether which can at least partially restrain the prosthesis from deployment.
    Type: Application
    Filed: June 21, 2018
    Publication date: October 18, 2018
    Inventors: Glen T. Rabito, J. Brent Ratz, Luca Pesce, Arshad Quadri, Lindsay Lam, Yen Liao, Julio Cesar Sanchez, David Robert Landon, Garrett Dallas Johnson, Alexander H. Cooper
  • Publication number: 20180256324
    Abstract: A method of deploying a prosthesis within a native mitral valve is disclosed. The expandable frame preferably includes about twelve proximal anchors, wherein the proximal anchors have free ends positioned radially outwardly from the frame in an expanded configuration. The expandable frame preferably includes about twelve distal anchors, wherein the distal anchors also have a free ends positioned radially outwardly from the frame and extend toward a proximal end when the frame is in the expanded configuration. A valve body is supported within the frame for preventing blood flow in one direction. The expandable frame is radially expanded during deployment, which causes the free ends of the proximal and distal anchors to move closer together. In the expanded configuration, the proximal anchors are positioned on an inflow side of the native mitral valve and the distal anchors are positioned on an outflow side of the native mitral valve.
    Type: Application
    Filed: May 14, 2018
    Publication date: September 13, 2018
    Inventors: Arshad Quadri, J. Brent Ratz
  • Publication number: 20180235755
    Abstract: A replacement heart valve and method of treating valve insufficiency includes an expandable frame configured to engage a native valve annulus. A valve body is coupled to the frame. The valve body can include a leaflet portion and possibly a skirt portion. A portion of the frame has a foreshortening portion configured to longitudinally expand when urged to a radially compacted state and longitudinally contract when urged to a radially expanded state. In one embodiment the valve skirt is attached to the frame so that it can adapt to changes in the length of the frame. A delivery device in some embodiments can use one or more coverings, such as sheaths, to controllably release the replacement heart valve at a native heart valve.
    Type: Application
    Filed: April 19, 2018
    Publication date: August 23, 2018
    Inventors: Arshad Quadri, J. Brent Ratz
  • Publication number: 20180235756
    Abstract: A replacement heart valve and method of treating valve insufficiency includes an expandable frame configured to engage a native valve annulus. A valve body is coupled to the frame. The valve body can include a leaflet portion and possibly a skirt portion. A portion of the frame has a foreshortening portion configured to longitudinally expand when urged to a radially compacted state and longitudinally contract when urged to a radially expanded state. In one embodiment the valve skirt is attached to the frame so that it can adapt to changes in the length of the frame. A delivery device in some embodiments can use one or more coverings, such as sheaths, to controllably release the replacement heart valve at a native heart valve.
    Type: Application
    Filed: April 24, 2018
    Publication date: August 23, 2018
    Inventors: Arshad Quadri, J. Brent Ratz
  • Publication number: 20180221143
    Abstract: A prosthesis can comprise an expandable frame, a plurality of distal anchors and a plurality of proximal anchors. The anchors can extend outwardly from the frame. The frame can be configured to radially expand and contract for deployment within a body cavity. The frame and anchors can have one of many different shapes and configurations. For example, when the frame is in an expanded configuration, the frame can have a larger cross-sectional dimension in a middle portion of the frame and a smaller cross-sectional dimension in a proximal portion and a distal portion of the frame, wherein the middle portion is between the proximal and distal portions. As another example, the anchors can have looped ends, the entire anchor may loop out from the frame.
    Type: Application
    Filed: April 6, 2018
    Publication date: August 9, 2018
    Inventors: J. Brent Ratz, Arshad Quadri, Luca Pesce
  • Patent number: 10004599
    Abstract: Devices, systems and methods are described herein a prosthesis for implantation within a lumen or body cavity and delivery devices for delivering the prosthesis to a location for implantation. A delivery system can include a plurality of components which are moveable relative to each other. The delivery system can include a nose cone which can cover at least a first end of the prosthesis, an outer elongate member which can cover at least a second end of the prosthesis, and a tether which can at least partially restrain the prosthesis from deployment.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: June 26, 2018
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventors: Glen T. Rabito, J. Brent Ratz, Luca Pesce, Arshad Quadri, Lindsay Lam, Yen Liao, Julio Cesar Sanchez, David Landon, Garrett Dallas Johnson, Alexander H. Cooper