Patents by Inventor J. Craig Venter
J. Craig Venter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9481880Abstract: The presently disclosed invention relates to methods of installing a genome isolated from one species (the donor) into suitably prepared cells of a second species (the recipient). Introduction of the donor genetic material into the recipient host cell effectively converts the recipient host cell into a new cell that, as a result of the operation of the donated genetic material, is functionally classified as belonging to the genus and species of the donor genetic material.Type: GrantFiled: May 1, 2008Date of Patent: November 1, 2016Assignee: Synthetic Genomics, Inc.Inventors: John I. Glass, Nina Alperovich, Clyde A. Hutchison, III, Carole Lartigue, Charles E. Merryman, Sanjay Vashee, J. Craig Venter
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Patent number: 9434974Abstract: A method is provided for introducing a genome into a cell or cell-like system. The introduced genome may occur in nature, be manmade with or without automation, or may be a hybrid of naturally occurring and manmade materials. The genome is obtained outside of a cell with minimal damage. Materials such as a proteins, RNAs, polycations, nucleoid condensation proteins, or gene translation systems may accompany the genome. The genome is installed into a naturally occurring cell or into a manmade cell-like system. A cell-like system or synthetic cell resulting from the practice of the provided method may be designed and used to yield gene-expression products, such as desired proteins. By enabling the synthesis of cells or cell-like systems comprising a wide variety of genomes, accompanying materials and membrane types, the provided method makes possible a broader field of experimentation and bioengineering than has been available using prior art methods.Type: GrantFiled: December 22, 2006Date of Patent: September 6, 2016Assignee: Synthetic Genomics, Inc.Inventors: John I. Glass, Lei Young, Carole Lartigue, Nacyra Assad-Garcia, Hamilton O. Smith, Clyde A. Hutchison, J. Craig Venter
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Publication number: 20160177322Abstract: Compositions and methods are disclosed herein for cloning a synthetic or a semi-synthetic donor genome in a heterologous host cell. In one embodiment, the donor genome can be further modified within a host cell. Modified or unmodified genomes can be further isolated from the host cell and transferred to a recipient cell. Methods disclosed herein can be used to alter donor genomes from intractable donor cells in more tractable host cells.Type: ApplicationFiled: February 23, 2016Publication date: June 23, 2016Inventors: Gwynedd A. Benders, John I. Glass, Clyde A. Hutchison, III, Carole Lartigue, Sanjay Vashee, Mikkel A. Algire, Hamilton O. Smith, Charles E. Merryman, Vladimir N. Noskov, Ray-Yuan Chuang, Daniel G. Gibson, J. Craig Venter
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Publication number: 20160177338Abstract: Compositions and methods are disclosed herein for cloning a donor genome in a heterologous host cell. In one embodiment, the donor genome can be further modified within a host cell. Modified or unmodified genomes can be further isolated from the host cell and transferred to a recipient cell. Methods disclosed herein can be used to alter donor genomes from intractable donor cells in more tractable host cells.Type: ApplicationFiled: February 29, 2016Publication date: June 23, 2016Inventors: Gwynedd A. Benders, John I. Glass, Clyde A. Hutchison, III, Carole Lartigue, Sanjay Vashee, Mikkel A. Algire, Hamilton O. Smith, Charles E. Merryman, Vladimir N. Noskov, Ray-Yuan Chuang, Daniel G. Gibson, J. Craig Venter
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Patent number: 9273310Abstract: Compositions and methods are disclosed herein for cloning a donor genome in a heterologous host cell. In one embodiment, the donor genome can be further modified within a host cell. Modified or unmodified genomes can be further isolated from the host cell and transferred to a recipient cell. Methods disclosed herein can be used to alter donor genomes from intractable donor cells in more tractable host cells.Type: GrantFiled: March 5, 2010Date of Patent: March 1, 2016Assignee: Synthetic Genomics, Inc.Inventors: Gwynedd A. Benders, John I. Glass, Clyde A. Hutchison, III, Carole Lartigue, Sanjay Vashee, Mikkel A. Algire, Hamilton O. Smith, Charles E. Merryman, Vladimir N. Noskov, Ray-Yuan Chuang, Daniel G. Gibson, J. Craig Venter
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Patent number: 9266929Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.Type: GrantFiled: August 1, 2014Date of Patent: February 23, 2016Assignee: GlaxoSmithKline Biologicals SAInventors: Claire Fraser, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Marirosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulio Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, J. Craig Venter
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Patent number: 9267132Abstract: Compositions and methods are disclosed herein for cloning a synthetic or a semi-synthetic donor genome in a heterologous host cell. In one embodiment, the donor genome can be further modified within a host cell. Modified or unmodified genomes can be further isolated from the host cell and transferred to a recipient cell. Methods disclosed herein can be used to alter donor genomes from intractable donor cells in more tractable host cells.Type: GrantFiled: May 19, 2010Date of Patent: February 23, 2016Assignee: Synthetic Genomics, Inc.Inventors: Gwynedd A. Benders, John I. Glass, Clyde A. Hutchison, Carole Lartigue, Sanjay Vashee, Mikkel A. Algire, Hamilton O. Smith, Charles E. Merryman, Vladimir N. Noskov, Ray-Yuan Chuang, Daniel G. Gibson, J. Craig Venter
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Publication number: 20160030545Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.Type: ApplicationFiled: July 21, 2015Publication date: February 4, 2016Applicant: GLAXOSMITHKLINE BIOLOGICALS SAInventors: Claire FRASER, Cesira GALEOTTI, Guido GRANDI, Erin HICKEY, Vega MASIGNANI, Marirosa MORA, Jeremy PETERSEN, Mariagrazia PIZZA, Rino RAPPUOLI, Giulio RATTI, Vincenzo SCARLATO, Maria SCARSELLI, Herve TETTELIN, J. Craig VENTER
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Patent number: 9249196Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.Type: GrantFiled: January 26, 2012Date of Patent: February 2, 2016Assignee: GlaxoSmithKline Biologicals SAInventors: Claire Fraser, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Marirosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulio Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, J. Craig Venter
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Patent number: 9249198Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.Type: GrantFiled: August 1, 2014Date of Patent: February 2, 2016Assignee: GlaxoSmithKline Biologicals SAInventors: Claire Fraser, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Marirosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulio Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, J. Craig Venter
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Patent number: 9139621Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.Type: GrantFiled: March 23, 2011Date of Patent: September 22, 2015Assignee: GlaxoSmithKline Biologicals SAInventors: Claire Fraser, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Marirosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulio Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, J. Craig Venter
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Publication number: 20150240280Abstract: The present invention relates to methods of joining two or more double-stranded (ds) or single-stranded (ss) DNA molecules of interest in vitro, wherein the distal region of the first DNA molecule and the proximal region of the second DNA molecule of each pair share a region of sequence identity. The method allows the joining of a large number of DNA fragments, in a predetermined order and orientation, without the use of restriction enzymes. It can be used, e.g., to join synthetically produced sub-fragments of a gene or genome of interest. Kits for performing the method are also disclosed. The methods of joining DNA molecules may be used to generate combinatorial libraries useful to generate, for example, optimal protein expression through codon optimization, gene optimization, and pathway optimization.Type: ApplicationFiled: March 2, 2015Publication date: August 27, 2015Inventors: Daniel G. Gibson, Hamilton O. Smith, Clyde A. Hutchison, Lei Young, J. Craig Venter
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Publication number: 20150086582Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.Type: ApplicationFiled: August 1, 2014Publication date: March 26, 2015Inventors: Claire FRASER, Cesira GALEOTTI, Guido GRANDI, Erin HICKEY, Vega MASIGNANI, Marirosa MORA, Jeremy PETERSEN, Mariagrazia PIZZA, Rino RAPPUOLI, Giulio RATTI, Vincenzo SCARLATO, Maria SCARSELLI, Herve TETTELIN, J. Craig VENTER
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Publication number: 20150079124Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.Type: ApplicationFiled: August 1, 2014Publication date: March 19, 2015Inventors: Claire FRASER, Cesira GALEOTTI, Guido GRANDI, Erin HICKEY, Vega MASIGNANI, Marirosa MORA, Jeremy PETERSEN, Mariagrazia PIZZA, Rino RAPPUOLI, Giulio RATTI, Vincenzo SCARLATO, Maria SCARSELLI, Herve TETTELIN, J. Craig VENTER
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Patent number: 8968999Abstract: The present invention relates to methods of joining two or more double-stranded (ds) or single-stranded (ss) DNA molecules of interest in vitro, wherein the distal region of the first DNA molecule and the proximal region of the second DNA molecule of each pair share a region of sequence identity. The method allows the joining of a large number of DNA fragments, in a predetermined order and orientation, without the use of restriction enzymes. It can be used, e.g., to join synthetically produced sub-fragments of a gene or genome of interest. Kits for performing the method are also disclosed. The methods of joining DNA molecules may be used to generate combinatorial libraries useful to generate, for example, optimal protein expression through codon optimization, gene optimization, and pathway optimization.Type: GrantFiled: February 13, 2009Date of Patent: March 3, 2015Assignee: Synthetic Genomics, Inc.Inventors: Daniel G. Gibson, Hamilton O. Smith, Clyde A. Hutchison, Lei Young, J. Craig Venter
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Publication number: 20140274808Abstract: The present invention provides a system for receiving biological sequence information and activating the synthesis of a biological entity. The system has a receiving unit for receiving a signal encoding biological sequence information transmitted from a transmitting unit. The transmitting unit can be present at a remote location from the receiving unit. The system also has an assembly unit connected to the receiving unit, and the assembly unit assembles the biological entity according to the biological sequence information. Thus, according to the present invention biological sequence information can be digitally transmitted to a remote location and the information converted into a biological entity, for example a protein useful as a vaccine, immediately upon being received by the receiving unit and without further human intervention after preparing the system for receipt of the information.Type: ApplicationFiled: August 16, 2013Publication date: September 18, 2014Applicant: Synthetic Genomics, Inc.Inventors: J. Craig Venter, Daniel Gibson, John E. Gill
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Patent number: 8524251Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.Type: GrantFiled: January 26, 2012Date of Patent: September 3, 2013Assignees: J. Craig Venter Institute, Inc., Novartis AGInventors: Claire Fraser, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Marirosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulio Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, J. Craig Venter
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Publication number: 20130178377Abstract: Described herein are highly accurate metaproteomic based methods for diagnosing urogenital and kidney infections, which are easy to perform and that also provide information regarding the extent of the infection, the causative agent(s) and the nature of the host response.Type: ApplicationFiled: December 27, 2012Publication date: July 11, 2013Applicant: J. Craig Venter InstituteInventor: J. Craig Venter Institute
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Patent number: 8448702Abstract: The present invention describes methods of identifying stimulants for the biogenic production of methane in hydrocarbon-bearing formations. Methods involve the use of microbial nucleic acid sequence information for the determination of gene products that are enzymes in a variety of pathways involved in the conversion of hydrocarbons to methane. Enzymes and stimulants identified by invention methods can be used in processes for enhancing biogenic methane production, for example, by addition to coal seams and coalbed methane wells.Type: GrantFiled: July 6, 2011Date of Patent: May 28, 2013Assignee: Synthetic Genomics, Inc.Inventors: Gerardo Vicente Toledo, Toby Howard Richardson, Ulrich Stingl, Eric J. Mathur, J. Craig Venter
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Publication number: 20120164166Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.Type: ApplicationFiled: January 26, 2012Publication date: June 28, 2012Applicants: NOVARTIS AG, J. CRAIG VENTER INSTITUTE, INC.Inventors: Claire Fraser, Cesira Galeotti, Guido Grandi, Erin Hickey, Vega Masignani, Marirosa Mora, Jeremy Petersen, Mariagrazia Pizza, Rino Rappuoli, Giulio Ratti, Vincenzo Scarlato, Maria Scarselli, Herve Tettelin, J. Craig Venter