Abstract: An impact fatigue device includes a striker rod assembly configured to reciprocally move between an upstream position and a downstream position. The striker rod assembly includes a striker rod slidingly mounted on a support member and a trigger located upstream of the striker rod and adapted to move downstream to engage the striker rod and propel the striker rod downstream. An actuator assembly is located upstream of the striker rod assembly. The actuator assembly is configured to releasably engage the trigger and to translate the trigger upstream. A reset mechanism is configured to releasably engage the striker rod and to move the striker rod from the downstream position to the upstream position. A method of operating the impact fatigue device is also disclosed.

Abstract: Embodiments of bridged tetrahydroisoquinolines and methods for their use in selectively inhibiting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 are disclosed. The disclosed compounds have a structure according to general formula I or a pharmaceutically acceptable salt thereof: wherein “” represents a single or double bond, R1 is hydrogen, halogen, lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; Ra is hydrogen, —CH2R2, R3, or —SO2R4; R2 is lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R3 is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R4 is lower aliphatic, or substituted or unsubstituted aryl; and R5 is hydrogen, halogen, or lower aliphatic.

Abstract: Embodiments of bridged tetrahydroisoquinolines and methods for their use in selectively inhibiting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 are disclosed. The disclosed compounds have a structure according to general formula I or a pharmaceutically acceptable salt thereof: wherein “” represents a single or double bond, R1 is hydrogen, halogen, lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; Ra is hydrogen, —CH2R2, R3, or —SO2R4; R2 is lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R3 is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R4 is lower aliphatic, or substituted or unsubstituted aryl; and R5 is hydrogen, halogen, or lower aliphatic.

Abstract: A method is provided for treatment of a condition mediated by Nox2 in a patient. The method comprises administering to the patient by inhalation a polypeptide as described herein, able to inhibit superoxide production by Nox2.

Abstract: A base station includes an antenna, a radio transceiver, an optical splitter, an optical-to-electrical converter, and a computation module. The antenna may be mounted to a tower and may be configured to receive an RF signal. The radio transceiver may be coupled to the antenna and mounted near the top of the tower. The transceiver may be configured to convert the RF signal to a baseband signal for transmission over a fiber optic link as a first optical signal. The splitter may be configured to split the first optical signal, received via the fiber optic link, into a second optical signal and a third optical signal. The optical-to-electrical converter may be configured to convert the second optical signal into an electrical digital signal including in-phase and quadrature (I/Q) data. The computation module may be configured to compute, based on the I/Q data, signal measurements for location of a mobile station.

Abstract: A method is provided for treatment of a condition mediated by Nox2 in a patient. The method comprises administering to the patient by inhalation a polypeptide as described herein, able to inhibit superoxide production by Nox2. Conditions treatable in this manner include, without limitation, one or more of: right ventricular hypertrophy; pulmonary hypertension; acute lung injury; obstructive sleep apnea; ischemia/reperfusion injury in the lung; pulmonary fibrosis; an obstructive lung disorder such as Chronic Obstructive Pulmonary Disease (COPD), asthma, cystic fibrosis and emphysema; and atherosclerosis.

Abstract: An impact fatigue device includes a striker rod assembly configured to reciprocally move between an upstream position and a downstream position. The striker rod assembly includes a striker rod slidingly mounted on a support member and a trigger located upstream of the striker rod and adapted to move downstream to engage the striker rod and propel the striker rod downstream. An actuator assembly is located upstream of the striker rod assembly. The actuator assembly is configured to releasably engage the trigger and to translate the trigger upstream. A reset mechanism is configured to releasably engage the striker rod and to move the striker rod from the downstream position to the upstream position. A method of operating the impact fatigue device is also disclosed.

Abstract: Embodiments of bridged tetrahydroisoquinolines and methods for their use in selectively inhibiting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 are disclosed. The disclosed compounds have a structure according to general formula I or a pharmaceutically acceptable salt thereof: wherein “” represents a single or double bond, R1 is hydrogen, halogen, lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; Ra is hydrogen, —CH2R2, R3, or —SO2R4; R2 is lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R3 is substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R4 is lower aliphatic, or substituted or unsubstituted aryl; and R5 is hydrogen, halogen, or lower aliphatic.

Abstract: A method is provided for treatment of a condition mediated by Nox2 in a patient. The method comprises administering to the patient by inhalation a polypeptide as described herein, able to inhibit superoxide production by Nox2.

Abstract: A cervical fixation system and method for repairing odontoid fractures includes securing an anterior plate to caudal portion of C2 body below the odontoid neck. The anterior plate houses lag screw within a posterior shaft. A cannulated fixation device crosses the fracture site with fixation into the cephalad fragment. The lag screw can be pulled caudally into the plate with a compression screw to apply a compression force across the fracture site.

Abstract: A method is provided for treatment of a condition mediated by Nox2 in a patient. The method comprises administering to the patient by inhalation a polypeptide as described herein, able to inhibit superoxide production by Nox2. Conditions treatable in this manner include, without limitation, one or more of: right ventricular hypertrophy; pulmonary hypertension; acute lung injury; obstructive sleep apnea; ischemia/reperfusion injury in the lung; pulmonary fibrosis; an obstructive lung disorder such as Chronic Obstructive Pulmonary Disease (COPD), asthma, cystic fibrosis and emphysema; and atherosclerosis.

Abstract: A cervical fixation system and method for repairing odontoid fractures includes securing an anterior plate to caudal portion of C2 body below the odontoid neck. The anterior plate houses lag screw within a posterior shaft. A cannulated fixation device crosses the fracture site with fixation into the cephalad fragment. The lag screw can be pulled caudally into the plate with a compression screw to apply a compression force across the fracture site.

Abstract: A cervical fixation system and method for repairing odontoid fractures includes securing an anterior plate to caudal portion of C2 body below the odontoid neck. The anterior plate houses lag screw within a posterior shaft. A cannulated fixation device crosses the fracture site with fixation into the cephalad fragment. The lag screw can be pulled caudally into the plate with a compression screw to apply a compression force across the fracture site.

Abstract: A method is provided for treatment of a condition mediated by Nox2 in a patient. The method comprises administering to the patient by inhalation a polypeptide as described herein, able to inhibit superoxide production by Nox2.

Abstract: A base station includes an antenna, a radio transceiver, an optical splitter, an optical-to-electrical converter, and a computation module. The antenna may be mounted to a tower and may be configured to receive an RF signal. The radio transceiver may be coupled to the antenna and mounted near the top of the tower. The transceiver may be configured to convert the RF signal to a baseband signal for transmission over a fiber optic link as a first optical signal. The splitter may be configured to split the first optical signal, received via the fiber optic link, into a second optical signal and a third optical signal. The optical-to-electrical converter may be configured to convert the second optical signal into an electrical digital signal including in-phase and quadrature (I/Q) data. The computation module may be configured to compute, based on the I/Q data, signal measurements for location of a mobile station.

Abstract: Instrumentation and method for treatment of a spinal structure, comprising an elongate member including a deformable distal portion having an initial configuration for placement within the spinal structure and a deformed configuration wherein the distal portion is outwardly deformed to form a cavity in the spinal structure. The elongate member comprises a cannula member and an actuator member that is removably positioned within the cannula member and configured to transition the deformable distal portion from the initial configuration toward the deformed configuration. The actuator member is selectively removed from the cannula member to provide a passageway for delivery of a material into the cavity formed in the spinal structure.

Abstract: A cervical fixation system and method for repairing odontoid fractures includes securing an anterior plate to caudal portion of C2 body below the odontoid neck. The anterior plate houses lag screw within a posterior shaft. A cannulated fixation device crosses the fracture site with fixation into the cephalad fragment. The lag screw can be pulled caudally into the plate with a compression screw to apply a compression force across the fracture site.

Abstract: A reconfigurable child's toy features a first configuration including a table with a top and a supporting pedestal and chairs about the table. A second configuration includes two or more of the chairs stacked on each other and the table top and supporting pedestal interlocked with the stacked chairs forming a play structure such as a tower, a rocket ship, or other round or square play structure.