Abstract: The present invention relates to fusion molecules that have binding specificity for pyoverdine type I, II and III and pyochelin and can be used in various applications, including diagnostic and/or therapeutic applications, for example, to inhibit or reduce growth of P. aeruginosa and/or to prevent or treat P. aeruginosa biofilm infection as well as diseases or disorders associated with P. aeruginosa biofilm infection. The present invention also concerns methods of producing the fusion molecules described herein as well as compositions and kits comprising such fusion molecules. The present invention further relates to nucleic acid molecules encoding the fusion molecules described herein.

Abstract: The present invention relates to fusion molecules that have binding specificity for pyoverdine type I, II and III and pyochelin and can be used in various applications, including diagnostic and/or therapeutic applications, for example, to inhibit or reduce growth of P. aeruginosa and/or to prevent or treat P. aeruginosa biofilm infection as well as diseases or disorders associated with P. aeruginosa biofilm infection. The present invention also concerns methods of producing the fusion molecules described herein as well as compositions and kits comprising such fusion molecules. The present invention further relates to nucleic acid molecules encoding the fusion molecules described herein.

Abstract: A modulator including a delta-sigma modulation circuit having an order greater than 1, and configured to modulate an input signal into a Pulse Density Modulated (PDM) signal; and a Pad Asymmetric Compensation (PAC) circuit configured to linearize a relation between a magnitude of the input signal and a number of rise or fall transitions of the PDM signal by maximizing the number of rise or fall transitions of the PDM signal, and to output a modified PDM signal, wherein the linearized relation is for compensating for any offset in the PDM signal.

Abstract: A modulator including a delta-sigma modulation circuit having an order greater than 1, and configured to modulate an input signal into a Pulse Density Modulated (PDM) signal; and a Pad Asymmetric Compensation (PAC) circuit configured to linearize a relation between a magnitude of the input signal and a number of rise or fall transitions of the PDM signal by maximizing the number of rise or fall transitions of the PDM signal, and to output a modified PDM signal, wherein the linearized relation is for compensating for any offset in the PDM signal.

Abstract: Methods and systems for checking the integrity of a system on chip (SOC) are described. The SOC can include a controller and one or more registers. Register value(s) from the register(s) can be obtained at a first time to generate a first set of register values. Process(es) of the SOC are executed at a second time after the first time. Register values can again be obtained from the registers at a third time after the second time to generate a second set of register values. The first set of register values can be compared with the second set of register values. Based on the comparison, an operating mode of the SOC can be adjusted. The SOC integrity verification system and method can be used in safety and/or monitoring application(s), such as ASIL applications. For example, the system and method can be used in partial or fully autonomous (self-driving) automotive systems.

Abstract: An Analog-to-Digital-Conversion control system includes a first sample and hold circuit configured to provide a first sampled output to be converted by an Analog-to-Digital-Converter, which comprises a first sampling control circuit configured to receive a first trigger information to trigger sampling of a first analog input and to receive a first collision detection information from the Analog-to-Digital-Converter to detect a collision, a first sample and hold stage coupled to the first sampling control circuit and configured to sample the first analog input, only if no collision has been detected by the first sampling control circuit, wherein the first sampling control circuit is further configured to check predefined first sampling criteria and to output a first conversion request to the Analog-to-Digital-Converter, only if the predefined first sampling criteria are fulfilled.

Abstract: In various embodiments, a circuitry configured to generate a voltage is provided. The circuitry may include a sequence generator configured to provide a sequence of data words consisting of bits. The number of bits is greater than two. The circuitry may further include a delta-sigma modulator configured to receive the sequence of data words provided by the sequence generator and to provide a delta-sigma modulated first single bit data stream at a first data rate, and a decimation filter configured to generate a stream of decimated data words from the first single bit data stream at a second data rate. The second data rate may be smaller than the first data rate, each decimated data word including a plurality of bits. The circuitry may further include a parallel-to-serial converter configured to convert the decimated data words to a second single bit data stream while preserving the second data rate.

Abstract: According to an embodiment, a controller system that is configured to drive a power switch includes a driver integrated circuit (IC), which includes an interface circuit, a synchronization circuit, and a drive circuit. The interface circuit is configured to receive a control scheme over a serial interface. The synchronization circuit is coupled to the interface circuit and is configured to receive an angular position signal and synchronize a drive signal with the angular position signal, where the drive signal is based on the control scheme. The drive circuit is coupled to the synchronization circuit and is configured to drive the power switch using the drive signal.

Abstract: An Analog-to-Digital-Conversion control system includes a first sample and hold circuit configured to provide a first sampled output to be converted by an Analog-to-Digital-Converter, which comprises a first sampling control circuit configured to receive a first trigger information to trigger sampling of a first analog input and to receive a first collision detection information from the Analog-to-Digital-Converter to detect a collision, a first sample and hold stage coupled to the first sampling control circuit and configured to sample the first analog input, only if no collision has been detected by the first sampling control circuit, wherein the first sampling control circuit is further configured to check predefined first sampling criteria and to output a first conversion request to the Analog-to-Digital-Converter, only if the predefined first sampling criteria are fulfilled.

Abstract: Techniques for driving a plurality of inductive actuators are described herein. According to these techniques, a driver unit includes a clock terminal that receives an external clock signal used by an external control unit. The driver unit further includes a serial bus interface configured to communicate with the external control unit via a serial bus. The serial bus is configured to communicate both of trigger commands synchronized to the external clock signal that indicate to at least one of a plurality of programmable control circuits (PCUs) to generate drive signals in response to the trigger commands that are synchronized with the external clock signal and data associated with at least one of the plurality of PCUs and synchronized with the external clock signal, wherein the data is used by the at least one of the plurality of PCUs to generate the drive signals in response to the trigger commands.

Abstract: Methods and systems for checking the integrity of a system on chip (SOC) are described. The SOC can include a controller and one or more registers. Register value(s) from the register(s) can be obtained at a first time to generate a first set of register values. Process(es) of the SOC are executed at a second time after the first time. Register values can again be obtained from the registers at a third time after the second time to generate a second set of register values. The first set of register values can be compared with the second set of register values. Based on the comparison, an operating mode of the SOC can be adjusted. The SOC integrity verification system and method can be used in safety and/or monitoring application(s), such as ASIL applications. For example, the system and method can be used in partial or fully autonomous (self-driving) automotive systems.

Abstract: A modulator operable to control an oscillator is described. The modulator can include a memory that stores oscillator control values and a bit streaming block. The bit streaming block can generate a bit stream based on the oscillator control values and transmit the bit stream to the oscillator to control an oscillation frequency of the oscillator. The modulator can also include a bit streaming loader (BSL). The BSL can receive one or more of the oscillator control values from the memory, generate one or more corresponding bit values based on the one or more of the oscillator control values, and provide the one or more bit values to the bit streaming block. The bit streaming block can then generate the bit stream based the one or more bit values generated by the BSL.

Abstract: A modulator operable to control an oscillator is described. The modulator can include a memory that stores oscillator control values and a bit streaming block. The bit streaming block can generate a bit stream based on the oscillator control values and transmit the bit stream to the oscillator to control an oscillation frequency of the oscillator. The modulator can also include a bit streaming loader (BSL). The BSL can receive one or more of the oscillator control values from the memory, generate one or more corresponding bit values based on the one or more of the oscillator control values, and provide the one or more bit values to the bit streaming block. The bit streaming block can then generate the bit stream based the one or more bit values generated by the BSL.

Abstract: An assembly includes first and second ropes and a suspension element. The first rope is securable to a first attachment in a work area. A person can be coupled to the first rope. The second rope is available for lowering the person. The suspension element is secured in a securing region. A force-transmitting coupling is creatable between the second rope and the suspension element. The first and second ropes are coupled to each other over a first lowering region. The second rope is decoupleable non-destructively from the first rope from an end of the first lowering region. A person can be lowered in a second lowering region by the second rope. The weight of the person in the second lowering region is transferable from the second rope via the suspension element to the securing region.

Abstract: According to an embodiment, a controller system that is configured to drive a power switch includes a driver integrated circuit (IC), which includes an interface circuit, a synchronization circuit, and a drive circuit. The interface circuit is configured to receive a control scheme over a serial interface. The synchronization circuit is coupled to the interface circuit and is configured to receive an angular position signal and synchronize a drive signal with the angular position signal, where the drive signal is based on the control scheme. The drive circuit is coupled to the synchronization circuit and is configured to drive the power switch using the drive signal.

Abstract: The present invention relates to fusion molecules that have binding specificity for pyoverdine type I, II and III and pyochelin and can be used in various applications, including diagnostic and/or therapeutic applications, for example, to inhibit or reduce growth of P. aeruginosa and/or to prevent or treat P. aeruginosa biofilm infection as well as diseases or disorders associated with P. aeruginosa biofilm infection. The present invention also concerns methods of producing the fusion molecules described herein as well as compositions and kits comprising such fusion molecules. The present invention further relates to nucleic acid molecules encoding the fusion molecules described herein.

Abstract: A current driving system for a solenoid valve is described herein. In an embodiment, the current driving system comprises a pre-driver to control a control input of a transistor coupled to an electrical input of a solenoid valve. The transistor inducts electric power into the solenoid valve when the transistor is switched on. The current driving system further comprises a signal generator to produce a small signal and to output the small signal to the electrical input of the solenoid valve. The electric power being supplied by the small signal into the solenoid valve is substantially smaller than the electric power being supplied by the transistor when the transistor is switched on. The current driving system further comprises a measurement unit to measure a response to the small signal at the electrical input of the solenoid valve.

Abstract: An electronic device comprises a substrate, at least one electronic chip mounted on and electrically connected to the substrate and being configured as a system control unit for controlling a connected system, a heat removal structure thermally connected to the at least one electronic chip and configured for removing heat generated by the at least one electronic chip upon operation of the electronic device, and an overmolding structure configured for at least partially encapsulating at least the at least one electronic chip and the substrate.

Abstract: An electronic switch includes a load path connected in series with the load and a drive terminal for receiving a drive signal. The electronic switch is operable to switch between a first operation state and a second operation state dependent on the drive signal. In a first switching cycle, the electronic switch is switched from the first operation state to the second operation state and a voltage across the load is evaluated during the first switching cycle in order to obtain a measured switching profile. The measured switching profile is compared with a reference profile. A drive profile dependent on the comparison is provided. The drive profile is used to drive the electronic switch in a second switching cycle after the first switching cycle. At least two drive parameters are used at different times in the at least one second switching cycle to drive the electronic switch.

Abstract: The invention relates to a method of diagnosis of colorectal cancer in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an increased concentration of a protein in the diagnostic sample, compared with a control, normal human sample, the protein being: transforming growth factor-beta induced protein IG-H3 (SwissProt Acc. No. Q15582); suppressor of G2 allele of SKP1 homolog (isoform 2) (SwissProt Acc. No. Q9Y2Z0-2); hypothetical protein (part of URG4) (SwissProt Acc. No. Q9NWR7); calponin-2 (SwissProt Acc. No. Q99439); heat shock protein HSP90-beta (SwissProt Acc. No. P08238); phosphoglycerate mutase 1 (SwissProt Acc. No. P18669); serpin C1 protein (SwissProt Acc. No. P01008); or haptoglobin precursor (SwissProt Acc. No. P00738); or a decreased concentration of a protein in the diagnostic sample, compared with a control, normal human sample, the protein being serotransferrin (SwissProt Acc. No. P02787); 26S proteasome subunit p40.5 (Swiss Prot Acc. No.