Patents by Inventor Ja Heouk Khoo

Ja Heouk Khoo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process For Preparing Aminopyrimidine Derivatives
    Publication number: 20230312545
    Abstract: The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. Additionally, the present invention provides novel intermediates useful for said process and processes for preparing the same.
    Type: Application
    Filed: June 2, 2023
    Publication date: October 5, 2023
    Inventors: Sang-Ho Oh, Ja-Heouk Khoo, Jong-Chul Lim, Seong-Ran Lee, Hyun Ju, Woo-Seob Shin, Dae-Gyu Park, Su-Min Park, Yoon-Ah Hwang
  • Process for preparing aminopyrimidine derivatives
    Patent number: 11708362
    Abstract: The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. Additional, the present invention provides novel intermediates useful for said process and processes for preparing the same.
    Type: Grant
    Filed: March 25, 2022
    Date of Patent: July 25, 2023
    Assignee: Yuhan Corporation
    Inventors: Sang-Ho Oh, Ja-Heouk Khoo, Jong-Chul Lim, Seong-Ran Lee, Hyun Ju, Woo-Seob Shin, Dae-Gyu Park, Su-Min Park, Yoon-Ah Hwang
  • Processes for preparing a diaminopyrimidine derivative or acid addition salt thereof
    Patent number: 11623925
    Abstract: The present invention provides a novel process for preparing a diaminopyrimidine derivative or acid addition salt thereof having an activity as a 5-HT4 receptor agonist. And also, the present invention provides novel crystalline forms of a hydrochloride of the diaminopyrimidine derivative and processes for preparing the same.
    Type: Grant
    Filed: July 26, 2022
    Date of Patent: April 11, 2023
    Assignee: YUHAN CORPORATION
    Inventors: Ja-Heouk Khoo, Doo-Byung Lee, Jun-Sup Lee, Hyun Ju, Woo-Seob Shin
  • NOVEL PROCESSES FOR PREPARING A DIAMINOPYRIMIDINE DERIVATIVE OR ACID ADDITION SALT THEREOF
    Publication number: 20220380344
    Abstract: The present invention provides a novel process for preparing a diaminopyrimidine derivative or acid addition salt thereof having an activity as a 5-HT4 receptor agonist. And also, the present invention provides novel crystalline forms of a hydrochloride of the diaminopyrimidine derivative and processes for preparing the same.
    Type: Application
    Filed: July 26, 2022
    Publication date: December 1, 2022
    Applicant: YUHAN CORPORATION
    Inventors: Ja-Heouk KHOO, Doo-Byung LEE, Jun-Sup LEE, Hyun JU, Woo-Seob SHIN
  • Process For Preparing Aminopyrimidine Derivatives
    Publication number: 20220281861
    Abstract: The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. Additional, the present invention provides novel intermediates useful for said process and processes for preparing the same.
    Type: Application
    Filed: March 25, 2022
    Publication date: September 8, 2022
    Inventors: Sang-Ho Oh, Ja-Heouk Khoo, Jong-Chul Lim, Seong-Ran Lee, Hyun Ju, Woo-Seob Shin, Dae-Gyu Park, Su-Min Park, Yoon-Ah Hwang
  • Processes for preparing a diaminopyrimidine derivative or acid addition salt thereof
    Patent number: 11434224
    Abstract: Provided are a novel process for preparing a diaminopyrimidine derivative or acid addition salt thereof having an activity as a 5-HT4 receptor agonist, crystalline forms of a hydrochloride of the diaminopyrimidine derivative, and processes for preparing the same.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: September 6, 2022
    Assignee: YUHAN CORPORATION
    Inventors: Ja-Heouk Khoo, Doo-Byung Lee, Jun-Sup Lee, Hyun Ju, Woo-Seob Shin
  • Process for preparing aminopyrimidine derivatives
    Patent number: 11286253
    Abstract: The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. Additional, the present invention provides novel intermediates useful for said process and processes for preparing the same.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: March 29, 2022
    Assignee: Yuhan Corporation
    Inventors: Sang-Ho Oh, Ja-Heouk Khoo, Jong-Chul Lim, Seong-Ran Lee, Hyun Ju, Woo-Seob Shin, Dae-Gyu Park, Su-Min Park, Yoon-Ah Hwang
  • Intermediates useful for the synthesis of a selective inhibitor against protein kinase and processes for preparing the same
    Patent number: 11198684
    Abstract: The present invention provides intermediates useful for the synthesis of an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors; and processes for preparing the same. And also, the present invention provides novel intermediates useful for said process and processes for preparing the same.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: December 14, 2021
    Assignee: Yuhan Corporation
    Inventors: Sang-Ho Oh, Ja-Heouk Khoo, Jong-Chul Lim, Doo-Byung Lee, Jung-Ae Lee, Jun-Sup Lee, Hyun Ju, Woo-Seob Shin, Sang-Seol Jeon
  • Process For Preparing Aminopyrimidine Derivatives
    Publication number: 20210269427
    Abstract: The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. Additional, the present invention provides novel intermediates useful for said process and processes for preparing the same.
    Type: Application
    Filed: December 8, 2020
    Publication date: September 2, 2021
    Inventors: Sang-Ho Oh, Ja-Heouk Khoo, Jong-Chul Lim, Seong-Ran Lee, Hyun Ju, Woo-Seob Shin, Dae-Gyu Park, Su-Min Park, Yoon-Ah Hwang
  • NOVEL PROCESSES FOR PREPARING A DIAMINOPYRIMIDINE DERIVATIVE OR ACID ADDITION SALT THEREOF
    Publication number: 20210206746
    Abstract: Provided are a novel process for preparing a diaminopyrimidine derivative or acid addition salt thereof having an activity as a 5-HT4 receptor agonist, crystalline forms of a hydrochloride of the diaminopyrimidine derivative, and processes for preparing the same.
    Type: Application
    Filed: May 16, 2019
    Publication date: July 8, 2021
    Applicant: YUHAN CORPORATION
    Inventors: Ja-Heouk KHOO, Doo-Byung LEE, Jun-Sup LEE, Hyun JU, Woo-Seob SHIN
  • INTERMEDIATES USEFUL FOR THE SYNTHESIS OF A SELECTIVE INHIBITOR AGAINST PROTEIN KINASE AND PROCESSES FOR PREPARING THE SAME
    Publication number: 20210155607
    Abstract: The present invention provides intermediates useful for the synthesis of an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors; and processes for preparing the same. And also, the present invention provides novel intermediates useful for said process and processes for preparing the same.
    Type: Application
    Filed: July 25, 2018
    Publication date: May 27, 2021
    Inventors: Sang-Ho OH, Ja-Heouk KHOO, Jong-Chul LIM, Doo-Byung LEE, Jung-Ae LEE, Jun-Sup LEE, Hyun JU, Woo-Seob SHIN, Sang-Seol JEON
  • Process for preparing aminopyrimidine derivatives
    Patent number: 10889578
    Abstract: The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. And also, the present invention provides novel intermediates useful for said process and processes for preparing the same.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: January 12, 2021
    Assignee: Yuhan Corporation
    Inventors: Sang-Ho Oh, Ja-Heouk Khoo, Jong-Chul Lim, Seong-Ran Lee, Hyun Ju, Woo-Seob Shin, Dae-Gyu Park, Su-Min Park, Yoon-Ah Hwang
  • Intermediates useful for the synthesis of aminopyrimidine derivatives, process for preparing the same, and process for preparing aminopyrimidine derivatives using the same
    Patent number: 10858353
    Abstract: The present invention provides a novel process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. And also, the present invention provides novel intermediates useful for said process and processes for preparing the same.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: December 8, 2020
    Assignee: Yuhan Corporation
    Inventors: Sang-Ho Oh, Ja-Heouk Khoo, Jong-Chul Lim, Doo-Byung Lee, Jung-Ae Lee, Jun-Sup Lee, Hyun Ju, Woo-Seob Shin, Sang-Seol Jeon
  • NOVEL INTERMEDIATES USEFUL FOR THE SYNTHESIS OF AMINOPYRIMIDINE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND PROCESS FOR PREPARING AMINOPYRIMIDINE DERIVATIVES USING THE SAME
    Publication number: 20200207750
    Abstract: The present invention provides a novel process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. And also, the present invention provides novel intermediates useful for said process and processes for preparing the same.
    Type: Application
    Filed: July 25, 2018
    Publication date: July 2, 2020
    Inventors: Sang-Ho OH, Ja-Heouk KHOO, Jong-Chul LIM, Doo-Byung LEE, Jung-Ae LEE, Jun-Sup LEE, Hyun JU, Woo-Seob SHIN, Sang-Seol JEON
  • IMPROVED PROCESS FOR PREPARING AMINOPYRIMIDINE DERIVATIVES
    Publication number: 20200165236
    Abstract: The present invention provides an improved process for preparing an aminopyrimidine derivative or pharmaceutically acceptable salt thereof having a selective inhibitory activity against protein kinases, especially against the protein kinases for mutant epidermal growth factor receptors. And also, the present invention provides novel intermediates useful for said process and processes for preparing the same.
    Type: Application
    Filed: July 25, 2018
    Publication date: May 28, 2020
    Inventors: Sang-Ho OH, Ja-Heouk KHOO, Jong-Chul LIM, Seong-Ran LEE, Hyun JU, Woo-Seob SHIN, Dae-Gyu PARK, Su-Min PARK, Yoon-Ah HWANG
  • Process for preparation of 2-methyl-2?-phenylpropionic acid derivatives and novel intermediate compounds
    Patent number: 8633223
    Abstract: The present invention relates to a process for preparing 2-methyl-2?-phenylpropionic acid derivatives showing antihistamine activity in more simplified way, intermediate compounds and their preparation processes used therefor. According to the present invention, pharmaceutically useful 2-methyl-2?-phenylpropionic acid derivatives can be prepared with high yield and purity on industrial scale.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: January 21, 2014
    Assignee: Yuhan Corporation
    Inventors: Chun-Ho Lee, Ja-Heouk Khoo, Kyoung-Chan Kwon, Hyun Ju
  • Process for preparation of 2-methyl-2?-phenylpropionic acid derivatives and novel intermediate compounds
    Patent number: 8487106
    Abstract: The present invention relates to a process for preparing 2-methyl-2?-phenylpropionic acid derivatives showing antihistamine activity in more simplified way, intermediate compounds and their preparation processes used therefore. According to the present invention, pharmaceutically useful 2-methyl-2?-phenylpropionic acid derivatives can be prepared with high yield and purity on industrial scale.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: July 16, 2013
    Assignee: Yuhan Corporation
    Inventors: Chun-Ho Lee, Ja-Heouk Khoo, Kyoung-Chan Kwon, Hyun Ju
  • Process for the preparation of HMG-COA reductase inhibitors and intermediates thereof
    Patent number: 8476432
    Abstract: The present invention provides an improved process for preparing HMG-CoA reductase inhibitors such as rosuvastatin calcium, fluvastatin sodium, and pitavastatin calcium under a mild condition, using a novel amide-bond-containing compound having R2—N—O—R1 moiety as a key intermediate. And also, the present invention provides the novel compound, an intermediate useful for the preparation thereof, and a process for the preparation thereof.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: July 2, 2013
    Assignee: Yuhan Corporation
    Inventors: Hyun Ju, Sang-Sun Joung, Hyun-Jik Yi, Ja-Heouk Khoo, Jong-Chul Lim, Jae-Gyu Kim
  • PROCESS FOR THE PREPARATION OF HMG-COA REDUCTASE INHIBITORS AND INTERMEDIATES THEREOF
    Publication number: 20130096303
    Abstract: The present invention provides an improved process for preparing HMG-CoA reductase inhibitors such as rosuvastatin calcium, fluvastatin sodium, and pitavastatin calcium under a mild condition, using a novel amide-bond-containing compound having R2—N—O—R1 moiety as a key intermediate. And also, the present invention provides the novel compound, an intermediate useful for the preparation thereof, and a process for the preparation thereof.
    Type: Application
    Filed: June 30, 2011
    Publication date: April 18, 2013
    Inventors: Hyun Ju, Sang-Sun Joung, Hyun-Jik Yi, Ja-Heouk Khoo, Jong-Chul Lim, Jae-Gyu Kim
  • Process for preparation of 2-methyl-2? phenylpropionic acid derivatives and novel intermediate compounds
    Patent number: 8367704
    Abstract: The present invention relates to a process for preparing 2-methyl-2?-phenylpropionic acid derivatives showing antihistamine activity in more simplified way, intermediate compounds and their preparation processes used therefor. According to the present invention, pharmaceutically useful 2-methyl-2?-phenylpropionic acid derivatives can be prepared with high yield and purity on industrial scale.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: February 5, 2013
    Assignee: Yuhan Corporation
    Inventors: Chun-Ho Lee, Ja-Heouk Khoo, Kyoung-Chan Kwon, Hyun Ju