Patents by Inventor Jack T. Crawford

Jack T. Crawford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rapid amplification-based subtyping of mycobacterium tuberculosis
    Patent number: 5652106
    Abstract: The present invention provides methods of detecting or distinguishing the DNA of an individual strain of Mycobacterium tuberculosis utilizing the polymerase chain reaction (PCR). Reproducible, unique patterns can be produced allowing the identification of unknown M. tuberculosis DNA by performing this reaction and comparing the pattern produced to the known reproducible, unique patterns. The invention further provides a kit useful to detect or distinguish the DNA of an individual strain of M. tuberculosis in a sample, comprising specific primers for use in PCR. The present invention also provides a method of determining the presence of a multidrug-resistant M. tuberculosis by detecting the presence of a specific arrangement of genomic DNA. Such detection can be done using PCR or a ligase chain reaction (LCR). The present invention provides nucleic acid sequences useful in detecting multidrug-resistant M. tuberculosis.
    Type: Grant
    Filed: October 25, 1995
    Date of Patent: July 29, 1997
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Bonnie B. Plikaytis, Thomas M. Shinnick, Jack T. Crawford
  • Repetitive DNA sequence specific for mycobacterium tuberculosis to be used for the diagnosis of tuberculosis
    Patent number: 5370998
    Abstract: A novel composition and/or methods for the diagnosis of tuberculosis wherein the composition comprises a repetitive DNA segment that is specific for members of the Mycobacterium tuberculosis complex. The DNA segment repeats in the chromosome of Mycobacterium tuberculosis complex, and is conserved in all copies of the chromosomes. A method comprises using an entire repetitive DNA sequence, or any part thereof, as a hybridization probe for the direct detection of Mycobacterium tuberculosis complex in clinical material. In another method, a smaller portion of an entire repetitive DNA sequence is amplified using polymerase chain reaction, yielding a 123 base-pair product.
    Type: Grant
    Filed: October 1, 1991
    Date of Patent: December 6, 1994
    Assignee: The Board of Trustees of The University of Arkansas
    Inventors: Jack T. Crawford, Kathleen D. Eisenach, M. Donald Cave, Joseph H. Bates
  • Repetitive DNA sequence specific for mycobacterium tuberculosis to be used for the diagnosis of tuberculosis
    Patent number: 5183737
    Abstract: A novel composition and/or methods for the diagnosis of tuberculosis wherein the composition comprises a repetitive DNA segment that is specific for members of the Mycobacterium tuberculosis complex. The DNA segment repeats in the chromosome of Mycobacterium tuberculosis complex, and is conserved in all copies of the chromosomes. A method comprises using an entire repetitive DNA sequence, or any part thereof, as a hybridization probe for the direct detection of Mycobacterium tuberculosis complex in clinical material. In another method, a smaller portion of an entire repetitive DNA sequence is amplified using polymerase chain reaction, yielding a 123 base-pair product.
    Type: Grant
    Filed: October 1, 1991
    Date of Patent: February 2, 1993
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Jack T. Crawford, Kathleen D. Eisenach, M. Donald Cave, Joseph H. Bates
  • Repetitive DNA sequence specific for mycobacterium tuberculosis to be used for the diagnosis of tuberculosis
    Patent number: 5168039
    Abstract: A novel composition and/or methods for the diagnosis of tuberculosis wherein the composition comprises a repetitive DNA segment that is specific for members of the Mycobacterium tuberculosis complex. The DNA segment repeats in the chromosome of Mycobacterium tuberculosis complex, and is conserved in all copies of the chromosomes. A method comprises using an entire repetitive DNA sequence, or any part thereof, as a hybridization probe for the direct detection of Mycobacterium tuberculosis complex in clinical material. In another method, a smaller portion of an entire repetitive DNA sequence is amplified using polymerase chain reaction, yielding a 123 base-pair product.
    Type: Grant
    Filed: September 28, 1990
    Date of Patent: December 1, 1992
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Jack T. Crawford, Kathleen D. Eisenach, M. Donald Cave, Joseph H. Bates