Patents by Inventor Jacque Zwahlen

Jacque Zwahlen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS, COMPOSITIONS AND KITS FOR INCREASING GENOME EDITING EFFICIENCY
    Publication number: 20220106615
    Abstract: Methods of editing a target genomic region(s), methods of repairing of a DNA break via a HDR pathway, methods of inhibiting or suppressing repair of a DNA break via a NHEJ pathway, and methods of modifying expression of a gene(s) or protein(s) comprise administering to one or more cells that include one or more target genomic regions, a genome editing system and a DNA protein-kinase (DNA-PK) inhibitor disclosed herein. Kits and compositions for editing a target gene comprise a genome editing system and a DNA-PK inhibitor disclosed herein.
    Type: Application
    Filed: August 20, 2021
    Publication date: April 7, 2022
    Inventors: Norzehan Abdul-Manan, David A. Newsome, Jacque Zwahlen
  • Methods, compositions and kits for increasing genome editing efficiency
    Patent number: 11124805
    Abstract: Methods of editing a target genomic region(s), methods of repairing of a DNA break via a HDR pathway, methods of inhibiting or suppressing repair of a DNA break via a NHEJ pathway, and methods of modifying expression of a gene(s) or protein(s) comprise administering to one or more cells that include one or more target genomic regions, a genome editing system and a DNA protein-kinase (DNAPK) inhibitor disclosed herein. Kits and compositions for editing a target gene comprise a genome editing system and a DNAPK inhibitor disclosed herein.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: September 21, 2021
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Norzehan Abdul-Manan, David A. Newsome, Jacque Zwahlen
  • METHODS, COMPOSITIONS AND KITS FOR INCREASING GENOME EDITING EFFICIENCY
    Publication number: 20190225990
    Abstract: Methods of editing a target genomic region(s), methods of repairing of a DNA break via a HDR pathway, methods of inhibiting or suppressing repair of a DNA break via a NHEJ pathway, and methods of modifying expression of a gene(s) or protein(s) comprise administering to one or more cells that include one or more target genomic regions, a genome editing system and a DNA protein-kinase (DNAPK) inhibitor disclosed herein. Kits and compositions for editing a target gene comprise a genome editing system and a DNAPK inhibitor disclosed herein.
    Type: Application
    Filed: July 13, 2017
    Publication date: July 25, 2019
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Norzehan Abdul-Manan, David A. Newsome, Jacque Zwahlen