Abstract: Rejection of local oscillator harmonic response is provided in a mixing circuit with a pair of harmonic gating switches serially connected to the outputs of a balanced differential switching mixer and controlled by a gate clock signal having twice the frequency of a local oscillator signal controlling the switching mixer. An aperture or duty cycle of the gate clock signal determines which harmonic is rejected or suppressed, which is preferably a third and/or fifth harmonic since response of the balanced differential switching mixer to even harmonics is negligible. The resulting simple, efficient circuit is readily integrated directly into a phase-alternating mixer structure for a chopper-direct-conversion radio.

Abstract: Rejection of local oscillator harmonic response is provided in a mixing circuit with a pair of harmonic gating switches serially connected to the outputs of a balanced differential switching mixer and controlled by a gate clock signal having twice the frequency of a local oscillator signal controlling the switching mixer. An aperture or duty cycle of the gate clock signal determines which harmonic is rejected or suppressed, which is preferably a third and/or fifth harmonic since response of the balanced differential switching mixer to even harmonics is negligible. The resulting simple, efficient circuit is readily integrated directly into a phase-alternating mixer structure for a chopper-direct-conversion radio.

Abstract: Microarrays are prepared by using a separate fiber for each compound being used in the microarray. The fibers are bundled and sectioned to form a thin microarray that may be glued to a backing.

Abstract: Highly hydrophobic compounds and hydrophobic proteins are solubilized in a non-aqueous solvent containing an electrolyte for electrophoretic separation. The non-aqueous solvent is an ionic liquid or a mixture of an organic solvent containing an ionic liquid in an amount to render the solvent electrically conductive and amenable for electrophoretic separation. The hydrophobic proteins are separated by electrophoresis using an electrophoresis gel that is compatible with the organic solvent and ionic liquid.

Abstract: Highly hydrophobic compounds and hydrophobic proteins are solubilized in a non-aqueous solvent containing an electrolyte for electrophoretic separation. The non-aqueous solvent is an ionic liquid or a mixture of an organic solvent containing an ionic liquid in an amount to render the solvent electrically conductive and amenable for electrophoretic separation. The hydrophobic proteins are separated by electrophoresis using an electrophoresis gel that is compatible with the organic solvent and ionic liquid.

Abstract: A hydraulic control and operating system is provided for a railroad car retarder to control the movement of railroad cars in railroad classification yard. The system utilizes a double-acting hydraulic cylinder to operate the retarder mechanism and includes a hydraulic control circuit that provides protection against pressure spikes and high pressure excursions, high and low temperature excursions, low oil levels and oil filter fouling. The above system not only shuts itself down to prevent damage, but provides a warning to maintenance staff that service should be performed long before a need for system shut-down is required. The system includes a central operating panel in the rail yard control center, remote control panel located at the position of the retarder and the system can be connected for operation from a completely remote location.

Abstract: Microarrays are prepared by using a separate fiber for each compound being used in the microarray. The fibers are bundled and sectioned to form a thin microarray that is glued to a backing.

Abstract: The present invention pertains to an electro-pneumatic retarder control (EPRC) valve for a pneumatic retarder that controls the speed of railroad cars in a marshaling yard. The EPRC valve has a housing that generally encloses and protects its various components. The housing has a lid that can be opened to gain access to a control panel mounted on an interior door. The control panel includes a display, keyboard and programmable logic controller or PLC module that can be adjusted to set the desired pressure levels of the retarder. The EPRC valve has a modular pressure control assembly that includes an intake and exhaust manifold, a retarder supply and return manifold and several interchangeable control lines formed by like-shaped control valves and components. A pilot air control assembly enables the PLC module to selectively open and close the control valves and lines to deliver or release pressurized air to the retarder.

Abstract: Highly hydrophobic compounds and hydrophobic proteins are solubilized in a non-aqueous solvent containing an electrolyte for electrophoretic separation. The non-aqueous solvent is an ionic liquid or a mixture of an organic solvent containing an ionic liquid in an amount to render the solvent electrically conductive and amenable for electrophoretic separation. The hydrophobic proteins are separated by electrophoresis using an electrophoresis gel that is compatible with the organic solvent and ionic liquid.

Abstract: A method is disclosed which relates to the placement of binding partners on microarrays, where such binding partners contain proteins, nucleic acids, biological cells and other bio-reactive components. The present invention discloses uses and methods for manufacture of microarrays constructed in part by sectioning bundles of tubules or rods containing matrix immobilized bio-reactive molecules to produce large numbers of sample chips. The chips so produced are processed by deposition to microarrays. The deposited chips can then be manipulated to partition the immobilizing matrix away from the bio-reactive molecules contained in the matrix and to place said partitioned molecules onto various surfaces for subsequent analysis, to include binding assays, hybridization reactions, diagnostic methods and a variety of cell interaction-determining methodologies.

Abstract: Microarrays are made from sections of a molded block having many channels. These channels, which are formed by casting and/or embedding a rod in a moldable solid, are used to immobilize biological and chemical binding components after rod removal. The microarrays can be used in general biological assays, clinical evaluations and chemical library analyses.

Abstract: Microarrays are prepared by using a separate fiber for each compound being used in the microarray. The fibers are bundled and sectioned to form a thin microarray that may be glued to a backing.

Abstract: A composition comprises a hydrophobic matrix, a reducible nitric oxide (NO) donor, and an intrinsic reductant reactably associated together with the reducible NO donor within the matrix, and releases an effective amount of NO from the matrix when wetted at physiological pH, independently of the presence or absence of extrinsic reducing agents. The composition inhibits the growth of target cells in a target medium.

Abstract: A method and apparatus for making a fiber, especially a fiber adapted for use in a sectioned array, are provided according to the invention. The method includes a step of supplying a composition into a mold or tubing wherein the composition solidifies in the mold or tubing. The method further includes a step of allowing the composition to solidify and form the fiber. The method further includes a step of placing a predetermined elongation force onto an end of the fiber, the predetermined elongation force causing an elongation and reduction in cross-section of the fiber and causing a separation of the fiber from an interior surface of the mold or tubing. The method further includes a step of substantially maintaining the predetermined elongation force to propagate the separation through the mold or tubing until the fiber is completely separated from the interior surface of the mold or tubing.

Abstract: Microarrays are prepared by using a separate fiber for each compound being used in the microarray. The fibers are bundled and sectioned to form a thin microarray that may be glued to a backing.

Abstract: A method is disclosed which relates to the placement of binding partners on microarrays, where such binding partners contain proteins, nucleic acids, biological cells and other bio-reactive components. The present invention discloses uses and methods for manufacture of microarrays constructed in part by sectioning bundles of tubules or rods containing matrix immobilized bio-reactive molecules to produce large numbers of sample chips. The chips so produced are processed by deposition to microarrays. The deposited chips can then be manipulated to partition the immobilizing matrix away from the bio-reactive molecules contained in the matrix and to place said partitioned molecules onto various surfaces for subsequent analysis, to include binding assays, hybridization reactions, diagnostic methods and a variety of cell interaction-determining methodologies.

Abstract: Controlled release membranes are prepared from polyureaurethane polymer derived from prepolymer units at least 75% of which are oxyethylene-based diols or polyols having essentially all of the hydroxyl groups capped with polyisocyanate are disclosed. The membranes are characterized by their biocompatibility and resistance to nonspecific protein adsorption and are particuarly useful for delivery of proteinaceous materials in drug-delivery systems, i.e., wound dressings. Also disclosed are novel biocompatible, protein-nonadsorptive hydrated polymers and the method of producing the same.

Abstract: The resistance to an oxidizer of a biocompatible polysulfone membrane can be enhanced by the incorporation of a specific hydrophilic polyurethane polymer.

Abstract: Affinity matrices useful for the chromatography and immobilization of biological materials and the method of preparing and using the same are disclosed. The affinity supports are based on hydrated polyurethane polymers which have been activated to provide a means for covalently attaching a variety of bioaffinity agents. The hydrated polymer matrices are characterized by their biocompatibility and resistance to nonspecific protein adsorption. Preferably, the prepolymers used to prepare the hydrated polymers are isocyanate-capped oxyethylene-based diols or polyols, at least 75% of said diols and polyols having a molecular weight of 7000 to about 30,000.

Abstract: A class of hydrophilic prepolymers and hydrated polymer gels are disclosed which are characterized by their transparency, biocompatibility and resistance to nonspecific protein adsorption. At least 75%, preferably at least 90%, of the prepolymers are isocyanate-capped oxyethylene-based diols or polyols having molecular weight of about 7000-30,000. Essentially all of the hydroxyl groups of the diols or polyols are capped with polyisocyanate prior to formation of the hydrated polymer.