Abstract: Compositions, and methods of using such compositions, useful for injection into the posterior segments of human or animal eyes are provided. Such compositions include small particles of a poorly soluble therapeutic agent that facilitates formation of concentrated regions of the therapeutic agent in the retinal pigmented epithelium of an eye. The particles are formed by combining a therapeutic agent with an ophthalmically acceptable polymer component. The particles have sizes less than about 3000 nanometers, and in some cases, less than about 200 nanometers. One example of a composition includes particles of triamcinolone acetonide and hyaluronic acid have a size less than about 3000 nanometers.

Abstract: Biocompatible intraocular microspheres and implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to treat or to prevent the occurrence of one or more ocular conditions, to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like, to enhance normal retinal function and/or to lower intraocular pressure.

Abstract: Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, among others.

Abstract: An extendible axle member (146 or 148) is provided for a pivoting axle of an agricultural harvester (100), the extendible axle member (146 or 148) having an elongate telescopic portion (400) with bearing surfaces for being slidably received in an outer axle member (142 or 144), wherein the elongate telescopic portion (400) is formed integral with and abuts a C-frame for supporting a steering knuckle (158 or 160).

Abstract: Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to prevent the occurrence of one or more ocular conditions, or to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like.

Abstract: Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants can be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, including reduction of an elevated intraocular pressure.

Abstract: An engine cranking system and a method of cranking an engine are provided. The engine cranking system comprises an engine, cranking motor, and capacitor. The engine cranking system further comprises an electrical path interconnecting the cranking motor or a battery to the capacitor. The engine cranking system further comprises a control circuit coupled to the capacitor. The control circuit comprises a timer operative to track temporal information. The control circuit is operative to apply a control voltage that varies in response to the tracked temporal information. The control circuit further comprises a relay included in the electrical path. The relay is operative to switch, in response to the control voltage, between an open-circuit condition, in which the relay interrupts the electrical path, and a closed-circuit condition.

Abstract: Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, among others.

Abstract: A system provides an intra-program event guide for display. The intra-program event guide enables a User to identify the events (e.g. scenes, episodes, alternative scenes, program portions etc.) occurring within a program and to initiate viewing (or initiate other functions associated with the event) via the guide. A method for processing information concerning intra-program events (e.g. comprising particular MPEG compatible groups of pictures (GOPS)) occurring within a program involves receiving signal data and identifying in the signal data information items describing intra-program events occurring during a program. The information items describing intra-program events are processed to provide processed data representative of intra-program events sequentially ordered by time and the processed data is communicated to a device. Generation of an intra-program event guide of the information items is initiated in response to user command.

Abstract: Gadgets integrate with spreadsheets and the spreadsheet calculation engine. A gadget is bound to a range of cells (one or more) within a sheet. When one or more of the cells of the bound range is accessed (e.g. selected, hovered over, edited, deleted, added), the gadget is notified. The gadget may use this information for updating a display rendered by the gadget and/or performing some other action. The gadget uses an Application Programming Interface (API) to create the binding, communicate with the spreadsheet, and perform actions in the spreadsheet. The gadget is a Named Item object within the spreadsheet such that the gadget may be viewed/displayed differently from other objects. Out of date requests from the gadget are attempted to be detected and prevented from being processed such that the gadget is not acting on the latest data.

Abstract: The present application discloses a method of shaping a working material (12) into an article, consisting of two primary stages: (a) in the absence of added heat, consolidating and shaping the working material into a pre-form shape using a dynamic hydroforming process that employs a rigid, male-shaped tool (32) and a non-rigid, female-shaped tool (23, 24, 26); and (b) in the presence of added heat, further consolidating and shaping the working material into the final shape using at least one additional rigid forming tool (50).

Abstract: Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to prevent the occurrence of one or more ocular conditions, or to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like.

Abstract: An extendible axle member (146, 148) is provided for an agricultural harvester (100), the axle (142, 144) having an elongate telescopic portion (400) with bearing surfaces (254, 256, 334, 336) for being slidably received in an outer axle member (142, 144).

Abstract: A system, computer-implemented method, and a computer program product are provided for an energy management modeling language. Selections of a location, a time, a first variable identifier, a second variable identifier, a third variable identifier, and text that specifies a transform based on an energy management modeling language primitive are received via a user interface. The first variable identifier, the second variable identifier, and the third variable identifier are reformatted based on the location and the time. The transform is executed based on the reformatted first variable and the reformatted second variable to create a result. The result is output based on the reformatted third variable.

Abstract: A system, computer-implemented method, and a computer program product are provided for a templatized reporting engine. A report output request is received. A template is retrieved based on report parameters in the report output request. A data generator based on the template is executed. Data generated by executing the data generator is inserted into the template. The template and the data is output as a report via a user interface.

Abstract: The present invention relates to a method for treating retinal diseases and a method for retinal neuroprotection, in a patient in need thereof which comprises of administering a therapeutically effective amount of a pharmaceutical composition comprising a therapeutically effective amount of 4-bromo-N-(imidazolidin-2-ylidene)-1H-benzimidazol-5-amine or pharmaceutically acceptable salts thereof.

Abstract: A system and method are provided for secure network communications. A proxy server receives meter data, from a meter of a set of meters via a local network, for an energy management server. The proxy server uses secure communications to send the meter data via a non-secure network to the energy management server.

Abstract: The present invention provides a sustained release implant for intraocular use to treat elevated intraocular pressure, which implant is configured for intracameral or anterior vitreal administration to a patient with elevated intraocular pressure (IOP), said implant comprising a core of an antihypertensive agent surrounded by a polymer, which limits the rate of passage of the antihypertensive agent from the implant into the eye of said patient and said implant provides a linear rate of release of therapeutically effective amounts of said anti-hypertensive agent into the eye for a period of time of between 14 days and 365 days.

Abstract: A delivery system includes a housing along with a tip connected to one end of the housing. A first cannula extending from the tip is provided for inserting a rod implant into tissue. A second cannula, concentrically disposed within the first cannula, is utilized to force the rod implant from the first cannula and for ejecting a fluid behind the inserted rod implant in the tissue.

Abstract: A system, computer-implemented method, and a computer program product are provided for a utility bill audit. Measured data is input from meters. Utility provider information is input. The utility provider information includes utility provider sub-costs and utility provider variables. System data is generated based on the measured data. The system data includes system sub-costs and system variables. If a utility provider sub-cost differs from a corresponding system sub-cost by more than a selected sub-cost error threshold, whether a utility provider variable differs from a corresponding system variable by more than a selected variable error threshold is determined. A user interface outputs a notice regarding whether utility provider information differs from corresponding system data.