Patents by Inventor James A. Sutton

James A. Sutton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9213865
    Abstract: In one embodiment of the present invention, a method includes verifying a master processor of a system; validating a trusted agent with the master processor if the master processor is verified; and launching the trusted agent on a plurality of processors of the system if the trusted agent is validated. After execution of such a trusted agent, a secure kernel may then be launched, in certain embodiments. The system may be a multiprocessor server system having a partially or fully connected topology with arbitrary point-to-point interconnects, for example.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: December 15, 2015
    Assignee: Intel Corporation
    Inventors: John H. Wilson, Ioannis T. Schoinas, Mazin S. Yousif, Linda J. Rankin, David W. Grawrock, Robert J. Greiner, James A. Sutton, Kushagra Vaid, Willard M. Wiseman
  • Publication number: 20150306085
    Abstract: The present invention provides a compound of formula I; wherein R1 is an alkyl pyrazole or an alkyl carboxamide, and R2 is a hydroxycycloalkyl; or a pharmaceutically acceptable salt thereof, and compositions containing these compounds, for use to treat a brain tumor, particularly glioblastoma. The invention provides effective treatment of a brain tumor and can be used by oral administration of a compound of Formula I as further described herein. The invention also provides a method to treat a subject having a brain tumor such as glioblastoma, wherein the method comprises administering to the subject an effective amount of a compound of Formula I. Gene signatures correlated with successful treatment using these methods are also disclosed.
    Type: Application
    Filed: June 29, 2015
    Publication date: October 29, 2015
    Applicant: Novartis AG
    Inventors: Dylan DANIEL, Johanna JOYCE, James SUTTON
  • Publication number: 20150152093
    Abstract: The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
    Type: Application
    Filed: March 12, 2014
    Publication date: June 4, 2015
    Applicant: NOVARTIS AG
    Inventors: Thomas Raymond Caferro, Zhuoliang Chen, Young Shin Cho, Abran Q. Costales, Julian Roy Levell, Gang Liu, James R. Manning, Martin Sendzik, Cynthia Shafer, Michael David Shultz, James Sutton, Yaping Wang, Qian Zhao
  • Patent number: 9043594
    Abstract: A method and apparatus for initiating secure operations in a microprocessor system is described. In one embodiment, one initiating logical processor initiates the process by halting the execution of the other logical processors, and then loading initialization and secure virtual machine monitor software into memory. The initiating processor then loads the initialization software into secure memory for authentication and execution. The initialization software then authenticates and registers the secure virtual machine monitor software prior to secure system operations.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: May 26, 2015
    Assignee: Intel Corporation
    Inventors: James A. Sutton, II, David W. Grawrock
  • Publication number: 20150059007
    Abstract: In one embodiment of the present invention, a method includes verifying a master processor of a system; validating a trusted agent with the master processor if the master processor is verified; and launching the trusted agent on a plurality of processors of the system if the trusted agent is validated. After execution of such a trusted agent, a secure kernel may then be launched, in certain embodiments. The system may be a multiprocessor server system having a partially or fully connected topology with arbitrary point-to-point interconnects, for example.
    Type: Application
    Filed: October 3, 2014
    Publication date: February 26, 2015
    Inventors: John H. Wilson, Ioannis T. Schoinas, Mazin S. Yousif, Linda J. Rankin, David W. Grawrock, Robert J. Greiner, James A. Sutton, Kushagra Vaid, Willard M. Wiseman
  • Patent number: 8874906
    Abstract: In one embodiment of the present invention, a method includes verifying a master processor of a system; validating a trusted agent with the master processor if the master processor is verified; and launching the trusted agent on a plurality of processors of the system if the trusted agent is validated. After execution of such a trusted agent, a secure kernel may then be launched, in certain embodiments. The system may be a multiprocessor server system having a partially or fully connected topology with arbitrary point-to-point interconnects, for example.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: October 28, 2014
    Assignee: Intel Corporation
    Inventors: John H. Wilson, Ioannis T. Schoinas, Mazin S. Yousif, Linda J. Rankin, David W. Grawrock, Robert J. Greiner, James A. Sutton, Kushagra Vaid, Williard M. Wiseman
  • Patent number: 8850098
    Abstract: A method and apparatus is described herein for supporting direct memory accesses between peer I/O devices. It is determined whether a guest physical address (GPA) referenced by an access generated from an I/O device, is within a range of GPAs associated with local I/O devices based at least in part on a GPA base and a GPA window size. If the GPA is within the window, then the GPA is translated to an HPA based at least in part on a base HPA associated with a local device and then forwarded to that local device. However, if the GPA is not within the window, then the access is forwarded upstream.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: September 30, 2014
    Assignee: Intel Corporation
    Inventors: Rajesh Madukkarumukumana, James A. Sutton, II, Ioannis Schoinas, Richard Uhlig
  • Publication number: 20140288076
    Abstract: The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a disease or condition mediated by CDK9.
    Type: Application
    Filed: June 4, 2014
    Publication date: September 25, 2014
    Applicant: NOVARTIS AG
    Inventors: Paul A. Barsanti, Cheng Hu, Jeff Jin, Robert Keyes, Robert Kucejko, Xiaodong Lin, Yue Pan, Keith B. Pfister, Martin Sendzik, James Sutton, Lifeng Wan
  • Publication number: 20140280073
    Abstract: System, method and computer readable media embodiments are disclosed for performing event based analysis where a first query is performed on a first data source to obtain a first set of records based on a first event and a second query (independent from the first query) is performed on a second data source to obtain a second set of records based on a second event. Each set of records includes analysis dimension variable and a time dimension. A result set is generated by combining the first and second sets of records to find an intersection of the two sets based at least partly on the time dimension variables. A binary mapping is generated from the result set to establish a distinct set of values of the analysis dimension variable that match the intersection of the two sets.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: FUTRIXIP LIMITED
    Inventors: Ian James Sutton, Syuzanna Vartkesovna Zakharova
  • Publication number: 20140275083
    Abstract: The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: NOVARTIS AG
    Inventors: Thomas Raymond CAFERRO, Zhuoliang CHEN, Young Shin CHO, Abran Q. COSTALES, Julian Roy LEVELL, Gang LIU, James R. MANNING, Martin SENDZIK, Cynthia SHAFER, Michael David SHULTZ, James SUTTON, Yaping WANG, Qian ZHAO
  • Publication number: 20140281467
    Abstract: A method and apparatus for initiating secure operations in a microprocessor system is described. In one embodiment, one initiating logical processor initiates the process by halting the execution of the other logical processors, and then loading initialization and secure virtual machine monitor software into memory. The initiating processor then loads the initialization software into secure memory for authentication and execution. The initialization software then authenticates and registers the secure virtual machine monitor software prior to secure system operations.
    Type: Application
    Filed: March 24, 2014
    Publication date: September 18, 2014
    Inventors: James A. Sutton, II, David W. Grawrock
  • Patent number: 8778951
    Abstract: The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided is a method of treating a disease or condition mediated by CDK9.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: July 15, 2014
    Assignee: Novartis AG
    Inventors: Paul A. Barsanti, Cheng Hu, Jeff Jin, Robert Keyes, Robert Kucejko, Xiaodong Lin, Yue Pan, Keith B. Pfister, Martin Sendzik, James Sutton, Lifeng Wan
  • Publication number: 20140164381
    Abstract: The invention provides a method of aggregate banding comprising defining an aggregate banding dimension for a first data source, the aggregate banding dimension including at least one aggregation variable, at least one banding variable, and at least one band based at least partly on the at least one banding variable; summarizing the data source based at least partly on the at least one aggregation variable, the summary including at least one distinct value of the at least one aggregation variable; and defining a mapping relationship of the at least one distinct value of the at least one aggregation variable to the or respective band(s) based on the value of the at least one banding variable. The invention further provides related systems and processor-executable instructions.
    Type: Application
    Filed: December 10, 2013
    Publication date: June 12, 2014
    Applicant: FUTRIXIP LIMITED
    Inventors: Ian James Sutton, Syuzanna Vartkesovna Zakharova
  • Patent number: 8706942
    Abstract: A method and apparatus is described herein for supporting direct memory accesses between peer I/O devices. It is determined whether a guest physical address (GPA) referenced by an access generated from an I/O device, is within a range of GPAs associated with local I/O devices based at least in part on a GPA base and a GPA window size. If the GPA is within the window, then the GPA is translated to an HPA based at least in part on a base HPA associated with a local device and then forwarded to that local device. However, if the GPA is not within the window, then the access is forwarded upstream.
    Type: Grant
    Filed: December 29, 2004
    Date of Patent: April 22, 2014
    Assignee: Intel Corporation
    Inventors: Rajesh Madukkarumukumana, James A. Sutton, II, Ioannis Schoinas, Richard Uhlig
  • Patent number: 8683191
    Abstract: Apparatuses, methods, and systems for reconfiguring a secure system are disclosed. In one embodiment, an apparatus includes a configuration storage location, a lock, and lock override logic. The configuration storage location is to store information to configure the apparatus. The lock is to prevent writes to the configuration storage location. The lock override logic is to allow instructions executed from sub-operating mode code to override the lock.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: March 25, 2014
    Assignee: Intel Corporation
    Inventors: Sham M. Datta, Mohan J. Kumar, Ernie Brickell, Ioannis T. Schoinas, James A. Sutton
  • Publication number: 20140065141
    Abstract: The present invention provides a compound of formula I; wherein R1 is an alkyl pyrazole or an alkyl carboxamide, and R2 is a hydroxycycloalkyl; or a pharmaceutically acceptable salt thereof, and compositions containing these compounds, for use to treat a brain tumor, particularly glioblastoma. The invention provides effective treatment of a brain tumor and can be used by oral administration of a compound of Formula I as further described herein. The invention also provides a method to treat a subject having a brain tumor such as glioblastoma, wherein the method comprises administering to the subject an effective amount of a compound of Formula I. Gene signatures correlated with successful treatment using these methods are also disclosed.
    Type: Application
    Filed: May 4, 2012
    Publication date: March 6, 2014
    Applicant: Novartis AG
    Inventors: Dylan Daniel, Johanna Joyce, James Sutton
  • Patent number: 8660266
    Abstract: Delivering a Direct Proof private key to a device installed in a client computer system in the field may be accomplished in a secure manner without requiring significant non-volatile storage in the device. A unique pseudo-random value is generated and stored in the device at manufacturing time. The pseudo-random value is used to generate a symmetric key for encrypting a data structure holding a Direct Proof private key and a private key digest associated with the device. The resulting encrypted data structure is stored on a protected on-line server accessible by the client computer system.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: February 25, 2014
    Assignee: Intel Corporation
    Inventors: James A. Sutton, II, Ernie F. Brickell, Clifford D. Hall, David W. Grawrock
  • Patent number: 8645688
    Abstract: A method and apparatus for initiating secure operations in a microprocessor system is described. In one embodiment, one initiating logical processor initiates the process by halting the execution of the other logical processors, and then loading initialization and secure virtual machine monitor software into memory. The initiating processor then loads the initialization software into secure memory for authentication and execution. The initialization software then authenticates and registers the secure virtual machine monitor software prior to secure system operations.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: February 4, 2014
    Assignee: Intel Corporation
    Inventors: James A. Sutton, II, David W. Grawrock
  • Publication number: 20140005070
    Abstract: The invention provides methods of monitoring differential gene expression of pharmacodynamic (PD) markers in a patient treated with a Cyclin Dependent Kinase Inhibitor (CDKI), methods of determining the sensitivity of a cell to a CDKI by measuring PD markers and methods of screening for candidate CKDI.
    Type: Application
    Filed: March 28, 2012
    Publication date: January 2, 2014
    Applicant: Novartis AG
    Inventors: Michel Faure, Zhenhai Gao, James Sutton, Guoying Karen Yu
  • Publication number: 20130324530
    Abstract: The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided are pharmaceutical compositions containing these compounds and methods of treating a disease or condition mediated by CDK9 using these compounds and compositions.
    Type: Application
    Filed: November 17, 2011
    Publication date: December 5, 2013
    Inventors: William R. Antonios-McCrea, Paul A. Barsanti, Cheng Hu, Xianming Jin, Eric J. Martin, Yue Pan, Keith B. Pfister, Martin Sendzik, James Sutton, Lifeng Wan