Patents by Inventor James Alan Kerschen

James Alan Kerschen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Efficient peptide couplings and their use in the synthesis and isolation of a cyclopenta (G) quinazoline trisodium salt
    Patent number: 9458188
    Abstract: A new method for the synthesis of L-Glutamyl-?-D-Glutamic acid and its use in the synthesis of (2R)-((4S)-carboxy-4-(4,N-(((6S)-2-(hydroxymethyl)-4-oxo-3,4,7,8-tetrahydro-3H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino)benzamido)butanamido)pentanedioic acid, 1 are provided. Also provided is an efficient method for the isolation and purification of the trisodium salt of the abovementioned acid, 2, in a form suitable for long term storage and use in a parenteral dosing form.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: October 4, 2016
    Assignee: BTG INTERNATIONAL LIMITED
    Inventors: James Alan Kerschen, Alexander James Bridges, Milind D. Choubal, Sean Mark Dalziel, Thomas Elliott Jacks, Andrew S. Thompson, James Robert Zeller
  • Skin Treatments Containing Carboxylic Acid-Substituted Idebenone Derivatives and Methods of Preparation and Use Thereof
    Publication number: 20160151260
    Abstract: The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.
    Type: Application
    Filed: February 8, 2016
    Publication date: June 2, 2016
    Inventors: Falko Diedrich, Birgit Neudecker, Eberhard Wieland, Joseph A. Lewis, III, Joespeh C. DiNardo, Andrew S. Thompson, James Alan Kerschen, Peter C. Wade
  • Compositions containing carboxylic acid-substituted derivatives
    Patent number: 9290436
    Abstract: The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: March 22, 2016
    Assignee: Elizabeth Arden, Inc.
    Inventors: Falko Diedrich, Birgit Neudecker, Eberhard Wieland, Joseph A. Lewis, II, Joseph C. DiNardo, Andrew S. Thompson, James Alan Kerschen, Peter C. Wade
  • Synthesis of cyclopentaquinazolines
    Patent number: 8809526
    Abstract: A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N—{N-{4-[N-((6S)-2 -hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin-6-yl)-N-(prop-2 -ynyl)amino]benzoyl}-L-?-glutamyl}-D-glutamic acid (ONX-0801).
    Type: Grant
    Filed: July 15, 2011
    Date of Patent: August 19, 2014
    Assignee: ONYX Pharmaceuticals, Inc.
    Inventors: James Alan Kerschen, Alexander James Bridges, Sean Mark Dalziel, Olivier Dapremont, Hyunjung Kim, Andrew S. Thompson, James Robert Zeller
  • Synthesis of Cyclopentaquinazolines
    Publication number: 20130211082
    Abstract: A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N-{N-{4-[N-((6S)-2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoyl}-L-?-glutamyl}-D-glutamic acid (ONX-0801).
    Type: Application
    Filed: July 15, 2011
    Publication date: August 15, 2013
    Applicant: ONYX Pharmaceuticals, Inc.
    Inventors: James Alan Kerschen, Alexander James Bridges, Sean Mark Daizlel, Olivier Dapremont, Hyunjung Kim, Andrew S. Thompson, James Robert Zeller
  • Skin treatments containing carboxylic acid-substituted idebenone derivatives and methods of preparation and use thereof
    Patent number: 8354550
    Abstract: The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted idebenone derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: January 15, 2013
    Assignee: Elizabeth Arden, Inc.
    Inventors: Falko Diedrich, Birgit Neudecker, Eberhard Wieland, Joseph A. Lewis, II, Joseph C. Dinardo, Andrew S. Thompson, James Alan Kerschen, Peter C. Wade
  • Skin treatments with carboxylic acid-substituted idebenone derivatives
    Patent number: 8173703
    Abstract: The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted idebenone derivatives, methods of treating skin changes by topical application of these carboxylic acid-substituted idebenone derivatives, and their methods of synthesis. The carboxylic acid-substituted idebenone derivatives of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the carboxylic acid-substituted idebenone derivatives of the present invention have an antioxidant effect that is useful in treating a skin change.
    Type: Grant
    Filed: October 6, 2009
    Date of Patent: May 8, 2012
    Assignee: Elizabeth Arden, Inc.
    Inventors: Falko Diedrich, Birgit Neudecker, Eberhard Wieland, Joseph A. Lewis, II, Joseph C. DiNardo, Andrew S. Thompson, James Alan Kerschen, Peter C. Wade
  • Antibacterial agents
    Publication number: 20030114666
    Abstract: The present invention provides compounds of formula (I): 1
    Type: Application
    Filed: June 18, 2002
    Publication date: June 19, 2003
    Inventors: Edmund Lee Ellsworth, James Alan Kerschen, Sharon Anne Powell, Joseph Peter Sanchez, Howard Daniel Hollis Showalter, Michael Andrew Stier, Tuan Phong Tran