Patents by Inventor James Angstman

James Angstman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180230494
    Abstract: The present invention relates to methods to improve the absolute rate of homology-directed repair (HDR) and/or to improve the relative rate of HDR compared with non-homologous end joining (NHEJ).
    Type: Application
    Filed: October 1, 2015
    Publication date: August 16, 2018
    Inventors: J. Keith JOUNG, Benjamin KLEINSTIVER, Jason Michael GEHRKE, Shengdar TSAI, James ANGSTMAN, Rebecca Tayler COTTMAN
  • Publication number: 20180208921
    Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
    Type: Application
    Filed: January 12, 2018
    Publication date: July 26, 2018
    Inventors: J. Keith Joung, James Angstman, Jeffry D. Sander, Morgan Maeder, Shengdar Tsai
  • Publication number: 20180187168
    Abstract: Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines in DNA, and methods of use thereof.
    Type: Application
    Filed: February 12, 2018
    Publication date: July 5, 2018
    Inventors: J. Keith Joung, Morgan Maeder, James Angstman
  • Patent number: 9890364
    Abstract: Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines in DNA, and methods of use thereof.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 13, 2018
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Morgan Maeder, James Angstman
  • Patent number: 9885033
    Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: February 6, 2018
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, James Angstman, Jeffry D. Sander, Morgan Maeder, Shengdar Tsai
  • Publication number: 20160024524
    Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Inventors: J. Keith Joung, James Angstman, Jeffry D. Sander, Morgan Maeder, Shengdar Tsai
  • Publication number: 20130323220
    Abstract: Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines in DNA, and methods of use thereof.
    Type: Application
    Filed: March 15, 2013
    Publication date: December 5, 2013
    Applicant: The General Hospital Corporation
    Inventors: J. Keith Joung, Morgan Maeder, James Angstman