Patents by Inventor James B. Doherty

James B. Doherty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ophthalmic compositions for treating ocular hypertension
    Publication number: 20040097575
    Abstract: This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
    Type: Application
    Filed: October 14, 2003
    Publication date: May 20, 2004
    Inventors: James B. Doherty, Meng-Hsin Chen, Luping Liu, Swaminathan R. Natarajan, Robert M. Tynebor
  • (Halo-benzo carbonyl)heterocyclo fused phenyl p38 kinase inhibiting agents
    Publication number: 20030092712
    Abstract: Compounds described by the chemical formula (I) or a pharmaceutically acceptable salt thereof: 1
    Type: Application
    Filed: December 17, 2001
    Publication date: May 15, 2003
    Inventors: James B. Doherty, John E. Stelmach, Meng-Hsin Chen, Luping Liu, Julianne A. Hunt, Rowena D. Ruzck, Joung L. Goulet, David D. Wisnoski, Swaminathan Ravi Natarajan, Kathleen M. Rupprecht, Jianming Bao, Shouwu Miao, Xingfang Hong, Peter J. Sinclair, Florida Kallashi
  • Substituted azetidinones as anti-inflammatory and antidegenerative agents
    Patent number: 5591737
    Abstract: New substituted azetidinones of the general Formula (I) which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described. ##STR1## wherein R.sub.4 is (a) ##STR2## or (b) ##STR3## where R.sub.x is carboxy C.sub.1-6 alkyl, benzyloxycarbonylC.sub.1-3 alkyl, or t-butoxycarbonylC.sub.1-3 alkyl,whereinQ is a covalent bond or ##STR4## wherein R.sub.5 and R.sub.6 are each individually C.sub.1-3 alkyl or hydrogen,Y is ##STR5## or a covalent bond.
    Type: Grant
    Filed: December 16, 1993
    Date of Patent: January 7, 1997
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Conrad P. Dorn, Philippe L. Durette, Paul E. Finke, Malcolm Maccoss, Sander G. Mills, Shrenik K. Shah, Soumya P. Sahoo, Jeffrey J. Hale, Thomas J. Lanza, William K. Hagmann
  • Substituted cephalosporin sulfones as anti-inflammatory and antidegenerative agents
    Patent number: 5364848
    Abstract: New substituted cephalosporin sulfones are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
    Type: Grant
    Filed: May 1, 1992
    Date of Patent: November 15, 1994
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Raymond A. Firestone, Paul E. Finke, William K. Hagmann, Shrenik K. Shah, Kevan R. Thompson
  • Substituted azetidinones as anti-inflammatory and antidegenerative agents
    Patent number: 5348953
    Abstract: New substituted azetidinones of the general formula (I) which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described.
    Type: Grant
    Filed: December 17, 1992
    Date of Patent: September 20, 1994
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Paul E. Finke, William K. Hagmann, Amy L. Kissinger, Malcolm MacCoss, Shrenik K. Shah
  • Substituted azetidinones as anti-inflammatory and antidegenerative agents
    Patent number: 5229381
    Abstract: New substituted azetidinones of the general formula (A') which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described.
    Type: Grant
    Filed: September 20, 1991
    Date of Patent: July 20, 1993
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Conrad P. Dorn, Paul E. Finke, William K. Hagmann, Malcolm MacCoss, Shrenik K. Shah
  • Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
    Patent number: 5132301
    Abstract: New substituted cephalosporin sulfones are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
    Type: Grant
    Filed: January 29, 1990
    Date of Patent: July 21, 1992
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Raymond A. Firestone, Paul E. Finke, William K. Hagmann, Shrenik K. Shah, Kevan R. Thompson
  • Cephalosporin derivatives as anti-inflammatory agents
    Patent number: 4891370
    Abstract: Derivatives of cephalosporin esters are found to be potent elastase inhibitors and therefore are useful antiinflammatory agents.
    Type: Grant
    Filed: December 14, 1981
    Date of Patent: January 2, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Morris Zimmerman, Bunnie M. Ashe, James B. Doherty
  • Penicillin derivatives as anti-inflammatory and antidegenerative agents
    Patent number: 4847247
    Abstract: Derivatives of Penicillin, their sulfoxides and sulfones are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
    Type: Grant
    Filed: October 16, 1986
    Date of Patent: July 11, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Kevan R. Thompson, Paul E. Finke, James B. Doherty
  • Tetrazolyl derivatives of beta-lactams useful as elastase inhibitors
    Patent number: 4845088
    Abstract: Tetrazolyl derivatives of .beta.-lactams are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
    Type: Grant
    Filed: June 5, 1987
    Date of Patent: July 4, 1989
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, William K. Hagmann, Paul E. Finke, Shrenik K. Shah
  • .beta.-Lactam derivatives as anti-inflammatory and antidegenerative agents
    Patent number: 4797396
    Abstract: .beta.-Lactam derivatives and analogs are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
    Type: Grant
    Filed: July 16, 1987
    Date of Patent: January 10, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Paul E. Finke, Morris Zimmerman, James B. Doherty, Bonnie M. Ashe, Conrad P. Dorn
  • Substituted 1-oxa-dethiacephalosporins as anti-inflammatory and antidegenerative agents
    Patent number: 4717722
    Abstract: Substituted 1-oxa-dethiacephalosporins are found to be effective elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
    Type: Grant
    Filed: May 7, 1984
    Date of Patent: January 5, 1988
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, William K. Hagmann
  • .beta.-lactam derivatives as anti-inflammatory and antidegenerative agents
    Patent number: 4711886
    Abstract: .beta.-Lactam derivatives and analogs are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
    Type: Grant
    Filed: July 2, 1984
    Date of Patent: December 8, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Paul E. Finke, James B. Doherty, Morris Zimmerman, Bonnie M. Ashe, Conrad P. Dorn
  • Tetrazolyl derivatives of .beta.-lactams useful as elastase inhibitors
    Patent number: 4699904
    Abstract: Tetrazolyl derivatives of .beta.-lactams are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
    Type: Grant
    Filed: July 1, 1985
    Date of Patent: October 13, 1987
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Paul E. Finke, William K. Hagmann, Shrenik K. Shah
  • Substituted cephalosporins as anti-inflammatory and antidegenerative agents
    Patent number: 4637999
    Abstract: Substituted cephalosporins are found to be potent elastase inhibitors and thereby useful antiinflammatory/antidegenerative agents.
    Type: Grant
    Filed: May 2, 1983
    Date of Patent: January 20, 1987
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Paul E. Finke, Raymond A. Firestone, Shrenik S. Shah, Kevan R. Thompson
  • Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents
    Patent number: 4623645
    Abstract: Substituted cephalosporin sulfoxides are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
    Type: Grant
    Filed: April 18, 1983
    Date of Patent: November 18, 1986
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Bonnie M. Ashe, Paul E. Finke, Raymond A. Firestone, Shrenik K. Shah, Morris Zimmerman
  • Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
    Patent number: 4547371
    Abstract: Substituted cephalosporin sulfones are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.
    Type: Grant
    Filed: April 18, 1983
    Date of Patent: October 15, 1985
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Bonnie M. Ashe, Paul E. Finke, Shrenik K. Shah, Kevan R. Thompson, Morris Zimmerman
  • Process for the preparation of 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivative
    Patent number: 4496741
    Abstract: 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives have been prepared from a 5-aroyl-7-hydroxycarbonyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxyli c acid derivative via selective decarboxylation.
    Type: Grant
    Filed: January 24, 1983
    Date of Patent: January 29, 1985
    Assignee: Merck & Co., Inc.
    Inventor: James B. Doherty
  • N-Carboxyl-thienamycin esters and analogs thereof as anti-inflammatory agents
    Patent number: 4495197
    Abstract: Derivatives of N-carboxyl-thienamycin esters and analogs thereof are found to be potent elastase inhibitors and thereby useful anti-inflammatory agents.
    Type: Grant
    Filed: May 24, 1982
    Date of Patent: January 22, 1985
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Morris Zimmerman, Bonnie M. Ashe
  • 1-Carbapenem-3-carboxylic esters as anti-inflammatory agents
    Patent number: 4493839
    Abstract: Derivatives of 1-carbapenem-3-carboxylic esters are found to be potent elastase inhibitors and therefore are useful anti-inflammatory agents.
    Type: Grant
    Filed: May 24, 1982
    Date of Patent: January 15, 1985
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Morris Zimmerman, Bonnie M. Ashe