Patents by Inventor James Edward Booth

James Edward Booth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of weak partitioning chromatography
    Patent number: 9144755
    Abstract: This invention relates to methods of using weak partitioning chromatography for the purification of a product from a load fluid containing one or more impurities. Further, the invention relates to methods of weak partitioning chromatography defined by operating conditions which cause a medium to bind least 1 mg of product per mL of medium, or alternatively, defined by a partition coefficient of at least 0.1.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: September 29, 2015
    Assignee: Wyeth LLC
    Inventors: Paul R. Brown, Jonathan Lee Coffman, Ranganathan Godavarti, Timothy Iskra, Brian D. Kelley, Suresh Vunnum, Shujun Sun, Tianning Yu, James Edward Booth, Mary Beth Switzer
  • METHODS OF PURIFYING SMALL MODULAR IMMUNOPHARMACEUTICAL PROTEINS
    Publication number: 20120141497
    Abstract: The present invention provides, among other things, methods of purifying or recovering proteins, in particular, small modular immunopharmaceutical (SMIPs™) proteins, from protein preparations containing high molecular weight (HMW) aggregates and other impurities based on hydroxyapatite chromatography. In some embodiments, the hydroxyapatite chromatography is used in combination with affinity chromatography and/or ion exchange chromatography. In some embodiments, inventive methods according to the invention involve no more than three chromatography steps. The present invention also provides proteins such as SMIPs™ purified according to the invention and pharmaceutical compositions containing the same.
    Type: Application
    Filed: March 11, 2010
    Publication date: June 7, 2012
    Applicant: Wyeth LLC
    Inventors: Christopher John Gallo, Shujun Sun, James Edward Booth, Jason Richard Cormier, Daniel Patrick Lacasse, Aaron Russell Noyes
  • Binding molecules for human factor VIII and factor VIII-like proteins
    Patent number: 6492105
    Abstract: Methods for detecting human factor VIII or factor VIII-like polypeptides in and isolating it from solutions such as blood or conditioned media are disclosed, together with reagents suitable for the purpose comprising binding moieties that recognize human factor VIII and/or a factor VIII-like polypeptide and form a binding complex therewith. Preferred polypeptide binding moieties are particularly disclosed.
    Type: Grant
    Filed: January 8, 2001
    Date of Patent: December 10, 2002
    Assignee: Dyax Corp.
    Inventors: Jinan Yu, M. Daniel Potter, Brian D. Kelley, Jeffrey S. Deetz, James Edward Booth
  • Binding molecules for human factor VIII and factor VIII-like proteins
    Publication number: 20010014456
    Abstract: Methods for detecting human factor VIII or factor VIII-like polypeptides in and isolating it from solutions such as blood or conditioned media are disclosed, together with reagents suitable for the purpose comprising binding moieties that recognize human factor VIII and/or a factor VIII-like polypeptide and form a binding complex therewith. Preferred polypeptide binding moieties are particularly disclosed.
    Type: Application
    Filed: January 8, 2001
    Publication date: August 16, 2001
    Inventors: Jinan Yu, M. Daniel Potter, Brian D. Kelley, Jeffrey S. Deetz, James Edward Booth
  • Polypeptides for binding human factor VIII and fragments of human factor VIII
    Patent number: 6197526
    Abstract: Methods for detecting human factor VIII or factor VIII-like polypeptides in and isolating it from solutions such as blood or conditioned media are disclosed, together with reagents suitable for the purpose comprising binding moieties that recognize human factor VIII and/or a factor VIII-like polypeptide and form a binding complex therewith. Preferred polypeptide binding moieties are particularly disclosed.
    Type: Grant
    Filed: January 4, 1999
    Date of Patent: March 6, 2001
    Assignees: Dyax Corp., Genetics Inst.
    Inventors: Jinan Yu, M. Daniel Potter, Brian D. Kelley, Jeffrey S. Deetz, James Edward Booth