Patents by Inventor James J. Benedict
James J. Benedict has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9745370Abstract: The present invention relates to antibodies that bind to a polypeptide at an epitope in the amino acid sequence of SEQ ID NO: 1 (e.g., a sericin polypeptide). The invention also provides methods and kits using the antibodies of the invention. In some embodiments, the antibody binds to a polypeptide at an epitope in the amino add sequence of SEQ ID NO: 2. In some embodiments, the antibody binds to a polypeptide at an epitope in the amino add sequence of SEQ ID NO: 3. In some embodiments, the polypeptide is a sericin polypeptide (e.g., a sericin isoform 1B polypeptide). In a related aspect, the invention features a method for selectively detecting sericin in a sample.Type: GrantFiled: March 12, 2015Date of Patent: August 29, 2017Assignee: Cerapedics, Inc.Inventors: James J. Benedict, Tristan Stuart Barnes, Claude George Lerner
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Publication number: 20170015736Abstract: The present invention relates to antibodies that bind to a polypeptide at an epitope in the amino acid sequence of SEQ ID NO: 1 (e.g., a sericin polypeptide). The invention also provides methods and kits using the antibodies of the invention. In some embodiments, the antibody binds to a polypeptide at an epitope in the amino add sequence of SEQ ID NO: 2. In some embodiments, the antibody binds to a polypeptide at an epitope in the amino add sequence of SEQ ID NO: 3. In some embodiments, the polypeptide is a sericin polypeptide (e.g., a sericin isoform 1B polypeptide). In a related aspect, the invention features a method for selectively detecting sericin in a sample.Type: ApplicationFiled: March 12, 2015Publication date: January 19, 2017Applicant: Cerapedics, Inc.Inventors: James J. BENEDICT, Tristan Stuart BARNES, Claude George LERNER
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Patent number: 9415139Abstract: The invention features fiber reinforced bone repair putties and fiber reinforced pliable lyophilized implants which are useful for the treatment of bone defects. The putties and lyophilized implants include ceramic particles. The formulations of the invention can exhibit reduced migration of the ceramic particles, and are mechanically strengthened so the materials can be aggressively manipulated by a physician during an implantation procedure without tearing or puncturing.Type: GrantFiled: December 21, 2012Date of Patent: August 16, 2016Assignee: Cerapedics, Inc.Inventors: James J. Benedict, Nolan Chase Hannigan, Katherine Suzanne Davis, Whitney Terese Young
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Publication number: 20160095955Abstract: A firm but pliable medical device for use as a bone graft substitute or bone graft extender retains its shape without the requirement of a containment device, such as a syringe. Because the device is solid, it is easy to locate or position in-vivo and, in the moist environment of the body, it will hold its shape well, for an extended time. Because the lyophilized pliable medical device is porous, it adsorbs blood and other beneficial cells containing body fluids, such as bone marrow, contributing to its superior bone repair efficacy in comparison to an analogous putty that has not been lyophilized. In addition these lyophilized pliable medical devices are easier to terminally steam sterilize than the analogous putty because there is no moisture present to boil and ‘blow-out’ of the containment device (syringe). The glycerin that is present in the formulation lends pliability but has a low vapor pressure.Type: ApplicationFiled: August 10, 2015Publication date: April 7, 2016Applicant: CERAPEDICS, INC.Inventors: James J. BENEDICT, Greg Allen BREWSTER, Donald Barclay FREEMAN
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Patent number: 9101694Abstract: A firm but pliable medical device for use as a bone graft substitute or bone graft extender retains its shape without the requirement of a containment device, such as a syringe. Because the device is solid, it is easy to locate or position in-vivo and, in the moist environment of the body, it will hold its shape well, for an extended time. Because the lyophilized pliable medical device is porous, it adsorbs blood and other beneficial cells containing body fluids, such as bone marrow, contributing to its superior bone repair efficacy in comparison to an analogous putty that has not been lyophilized. In addition these lyophilized pliable medical devices are easier to terminally steam sterilize than the analogous putty because there is no moisture present to boil and “blow-out” of the containment device (syringe). The glycerin that is present in the formulation lends pliability but has a low vapor pressure.Type: GrantFiled: December 15, 2006Date of Patent: August 11, 2015Assignee: Cerapedics Inc.Inventors: James J. Benedict, Greg Allen Brewster, Donald Barclay Freeman
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Publication number: 20130244942Abstract: The invention features fiber reinforced bone repair putties and fiber reinforced pliable lyophilized implants which are useful for the treatment of bone defects. The putties and lyophilized implants include ceramic particles. The formulations of the invention can exhibit reduced migration of the ceramic particles, and are mechanically strengthened so the materials can be aggressively manipulated by a physician during an implantation procedure without tearing or puncturing.Type: ApplicationFiled: December 21, 2012Publication date: September 19, 2013Applicant: Cerapedics, Inc.Inventors: James J. BENEDICT, Nolan Chase Hannigan, Katherine Suzanne Davis, Whitney Terese Young
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Patent number: 8497236Abstract: The present invention provides compositions for an implantable putty material for delivery of active compounds to a patient. More specifically, the present invention provides a material having a pH of between about 3 and 6 and possessing putty-like physical properties, wherein the composition of the material includes collagen and water. The present invention also provides a method for using the implantable putty material.Type: GrantFiled: July 25, 2008Date of Patent: July 30, 2013Assignee: Zimmer Orthobiologics, Inc.Inventors: James J. Benedict, Christopher J. Damien
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Publication number: 20110027332Abstract: A firm but pliable medical device for use as a bone graft substitute or bone graft extender retains its shape without the requirement of a containment device, such as a syringe. Because the device is solid, it is easy to locate or position in-vivo and, in the moist environment of the body, it will hold its shape well, for an extended time. Because the lyophilized pliable medical device is porous, it adsorbs blood and other beneficial cells containing body fluids, such as bone marrow, contributing to its superior bone repair efficacy in comparison to an analogous putty that has not been lyophilized. In addition these lyophilized pliable medical devices are easier to terminally steam sterilize than the analogous putty because there is no moisture present to boil and “blow-out” of the containment device (syringe). The glycerin that is present in the formulation lends pliability but has a low vapor pressure.Type: ApplicationFiled: December 15, 2006Publication date: February 3, 2011Applicant: CERAPEDICS, INC.Inventors: James J. Benedict, Greg Allen Brewster, Donald Barclay Greeman
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Publication number: 20090297605Abstract: The composition as described serves for in vivo cartilage repair. It basically consists of a naturally derived osteoinductive and/or chondroinductive mixture of factors (e.g. derived from bone) or of a synthetic mimic of such a mixture combined with a nanosphere delivery system. A preferred mixture of factors is the combination of factors isolated from bone, known as BP and described by Poser and Benedict (WO 95/13767). The nanosphere delivery system consists of nanospheres defined as polymer particles of less than 1000 nm in diameter (whereby the majority of particles preferably ranges between 200-400 nm) in which nanospheres the combination of factors is encapsulated. The nanospheres are loaded with the mixture of factors in a weight ratio of 0.001 to 17% (w/w), preferably of 1 to 4% (w/w) and have a release profile with an initial burst of 10 to 20% of the total load over the first 24 hours and a long time release of at least 0.1 per day during at least seven following days.Type: ApplicationFiled: May 8, 2009Publication date: December 3, 2009Inventors: Brent L. Atkinson, Pedro Bittman, James J. Benedict, John Ranieri, Marsha L. Whitney, Donald Chickering
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Publication number: 20080293617Abstract: The present invention provides compositions for an implantable putty material for delivery of active compounds to a patient. More specifically, the present invention provides a material having a pH of between about 3 and 6 and possessing putty-like physical properties, wherein the composition of the material includes collagen and water. The present invention also provides a method for using the implantable putty material.Type: ApplicationFiled: July 25, 2008Publication date: November 27, 2008Inventors: James J. Benedict, Christopher J. Damien
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Patent number: 7087577Abstract: An angiogenic factor comprising a mixture of proteins derived from bone. The angiogenic protein mixture is produced by a series of steps that allow the proteins to be kept in solution. The angiogenic mixture of bone proteins is produced by a multi-step process that includes at least one ultrafiltration step, an anion exchange chromatography step, a cation exchange chromatography step and a high performance liquid chromatography (HPLC) purification step.Type: GrantFiled: December 22, 2000Date of Patent: August 8, 2006Assignee: Zimmer OrthoBiologies, Inc.Inventors: James J. Benedict, John P. Ranieri, Marsha L. Whitney, Rama Akella
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Publication number: 20040081704Abstract: The present invention provides compositions for an implantable putty material for delivery of active compounds to a patient. More specifically, the present invention provides a material having a pH of between about 3 and 6 and possessing putty-like physical properties, wherein the composition of the material includes collagen and water. The present invention also provides a method for using the implantable putty material.Type: ApplicationFiled: December 17, 2003Publication date: April 29, 2004Applicant: Centerpulse Biologics Inc.Inventors: James J. Benedict, Christopher J. Damien
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Patent number: 6679918Abstract: The present invention provides compositions for an implantable putty material for delivery of active compounds to a patient. More specifically, the present invention provides a material having a pH of between about 3 and 6 and possessing putty-like physical properties, wherein the composition of the material includes collagen and water. The present invention also provides a method for using the implantable putty material.Type: GrantFiled: February 13, 1998Date of Patent: January 20, 2004Assignee: Centerpulse Biologics Inc.Inventors: James J. Benedict, Christopher J. Damien
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Publication number: 20030236574Abstract: The composition as described serves for in vivo cartilage repair. It basically consists of a naturally derived osteoinductive and/or chondroinductive mixture of factors (e.g. derived from bone) or of a synthetic mimic of such a mixture combined with a nanosphere delivery system. A preferred mixture of factors is the combination of factors isolated from bone, known as BP and described by Poser and Benedict (WO 95/13767). The nanosphere delivery system consists of nanospheres defined as polymer particles of less than 1000 nm in diameter (whereby the majority of particles preferably ranges between 200-400 nm) in which nanospheres the combination of factors is encapsulated. The nano-spheres are loaded with the mixture of factors in a weight ratio of 0.001 to 17% (w/w), preferably of 1 to 4% (w/w) and have a release profile with an initial burst of 10 to 20% of the total load over the first 24 hours and a long time release of at least 0.1 per day during at least seven following days.Type: ApplicationFiled: March 11, 2003Publication date: December 25, 2003Applicant: Sulzer Innotec AGInventors: Pedro Bittman, Brent L. Atkinson, James J. Benedict, John Ranieri, Marsha L. Whitney, Donald Chickering
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Publication number: 20030232784Abstract: Herein is disclosed a composition, comprising a superoxide dismutase mimic (SODm) associated with hyaluronic acid (HA), wherein the composition is a liquid at about 37° C. The composition is useful in a method of treating pain or inflammation in a joint of a mammal, comprising (i) providing the composition and (ii) injecting the composition into or close to the joint.Type: ApplicationFiled: June 14, 2002Publication date: December 18, 2003Inventor: James J. Benedict
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Patent number: 6627230Abstract: A method and apparatus for preparing a bone product are provided. The method includes contacting an interior section of a cylindrical bone portion with a high pressure fluid medium such as at least about 1000 psi to remove at least a portion of cancellous bone matrix from the bone portion. Preferably the bone contains less than about 25% by weight cancellous bone. The apparatus includes multiple stations of opposing high pressure nozzles holding the cylindrical bone portion from each end and for contacting the interior surfaces of a bone portion with a fluid medium. The apparatus also includes a third nozzle for contacting the exterior surface of the bone portion with a fluid medium.Type: GrantFiled: December 22, 2000Date of Patent: September 30, 2003Assignee: Centerpulse Biologics Inc.Inventors: James J. Benedict, Frank Fisher, Colin Brock
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Patent number: 6582471Abstract: The composition as described serves for in vivo cartilage repair. It basically consists of a naturally derived osteoinductive and/or chondroinductive mixture of factors (e.g. derived from bone) or of a synthetic mimic of such a mixture combined with a nanosphere delivery system. A preferred mixture of factors is the combination of factors isolated from bone, known as BP and described by Poser and Benedict (WO 95/13767). The nanosphere delivery system consists of nanospheres defined as polymer particles of less than 1000 nm in diameter (whereby the majority of particles preferably ranges between 200-400 nm) in which nanospheres the combination of factors is encapsulated. The nanospheres are loaded with the mixture of factors in a weight ratio of 0.001 to 17% (w/w), preferably of 1 to 4% (w/w) and have a release profile with an initial burst of 10 to 20% of the total load over the first 24 hours and a long time release of at least 0.1 per day during at least seven following days.Type: GrantFiled: September 13, 2000Date of Patent: June 24, 2003Assignee: Sulzer Innotec AGInventors: Pedro Bittmann, Brent Atkinson, James J. Benedict, John Ranieri, Marsha L. Whitney, Donald Chickering
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Patent number: 6514514Abstract: Disclosed is a cartilage repair product that induces both cell ingrowth into a bioresorbable material and cell differentiation into cartilage tissue. Such a product is useful for regenerating and/or repairing both vascular and avascular cartilage lesions, particularly articular cartilage lesions, and even more particularly mensical tissue lesions, including tears as well as segmental defects. Also disclosed is a method of regenerating and repairing cartilage lesions using such a product.Type: GrantFiled: February 16, 1999Date of Patent: February 4, 2003Assignee: Sùlzer Biologics Inc.Inventors: Brent Atkinson, James J. Benedict
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Patent number: 6511958Abstract: Disclosed is a cartilage repair product that induces both cell ingrowth into a bioresorbable material and cell differentiation into cartilage tissue. Such a product is useful for regenerating and/or repairing both vascular and avascular cartilage lesions, particularly articular cartilage lesions, and even more particularly mensical tissue lesions, including tears as well as segmental defects. Also disclosed is a method of regenerating and repairing cartilage lesions using such a product.Type: GrantFiled: February 16, 2000Date of Patent: January 28, 2003Assignee: Sulzer Biologics, Inc.Inventors: Brent Atkinson, James J. Benedict
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Patent number: RE41286Abstract: Disclosed is a cartilage repair product that induces both cell ingrowth into a bioresorbable material and cell differentiation into cartilage tissue. Such a product is useful for regenerating and/or repairing both vascular and avascular cartilage lesions, particularly articular cartilage lesions, and even more particularly mensical tissue lesions, including tears as well as segmental defects. Also disclosed is a method of regenerating and repairing cartilage lesions using such a product.Type: GrantFiled: January 28, 2005Date of Patent: April 27, 2010Assignee: Zimmer Orthobiologics, Inc.Inventors: Brent Atkinson, James J. Benedict