Patents by Inventor James J. McNally

James J. McNally has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thiozanthene derivatives as delta-opioid modulators
    Patent number: 7982042
    Abstract: The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic ?-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: July 19, 2011
    Assignee: Janseen Pharmacautica NV
    Inventors: John R. Carson, Ellen Codd, Christine M. Razler, Andrea Works, Mark McDonnell, James J. McNally
  • HETERO-SUBSTITUTED ACETANILIDE DERIVATIVES AS ANALGESIC AGENTS
    Publication number: 20100204284
    Abstract: Hetero-substituted acetanilide derivatives are disclosed as analgesic agents. The compounds of the invention are useful in methods for treating a disease or condition in a mammal characterized by pain and/or fever.
    Type: Application
    Filed: March 31, 2010
    Publication date: August 12, 2010
    Inventors: John R. Carson, James J. McNally
  • SULFONAMIDES AS TRPM8 MODULATORS
    Publication number: 20100160289
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) and Formula (II) as follows: wherein Y, R1, R2, R3, R4, RA, and RB are defined herein.
    Type: Application
    Filed: December 15, 2009
    Publication date: June 24, 2010
    Inventors: Mark J. Macielag, James J. McNally
  • AMINOTETRALIN-DERIVED UREA MODULATORS OF VANILLOID VR1 RECEPTOR
    Publication number: 20100125140
    Abstract: This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to ?-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
    Type: Application
    Filed: January 22, 2010
    Publication date: May 20, 2010
    Inventors: Ellen Codd, Scott L. Dax, Michele Jetter, Mark McDonnell, James J. McNally, Mark Youngman
  • Hetero-substituted acetanilide derivatives as analgesic agents
    Patent number: 7718692
    Abstract: Hetero-substituted acetanilide derivatives are disclosed as analgesic agents. The compounds of the invention are useful in methods for treating a disease or condition in a mammal characterized by pain and/or fever.
    Type: Grant
    Filed: February 13, 2004
    Date of Patent: May 18, 2010
    Inventors: John R. Carson, James J. McNally
  • TRICYCLIC DELTA OPIOID MODULATORS
    Publication number: 20100093709
    Abstract: The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic ?-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
    Type: Application
    Filed: November 20, 2009
    Publication date: April 15, 2010
    Inventors: Steven J. Coats, Scott L. Dax, Bart DeCorte, Li Liu, Mark McDonnell, James J. McNally
  • Aminotetralin-derived urea modulators of vanilloid VR1 receptor
    Patent number: 7678812
    Abstract: This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to ?-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: March 16, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Ellen Codd, Scott L. Dax, Michele Jetter, Mark McDonnell, James J. McNally, Mark Youngman
  • Tricyclic ?-opioid modulators
    Patent number: 7652005
    Abstract: The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic ?-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
    Type: Grant
    Filed: October 9, 2008
    Date of Patent: January 26, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Steve Coats, Scott L. Dax, Bart DeCorte, Li Liu, Mark McDonnell, James J. McNally
  • RADIOLABELLED TRP M8 RECEPTOR LIGANDS
    Publication number: 20100015053
    Abstract: The present invention is directed to radiolabelled ligands, useful for the labeling and imaging of TRP M8 (transient receptor potential M8 channel) functionality. The present invention is further directed to pharmaceutical compositions comprising the radiolabelled ligands and methods for the preparation of the radiolabelled ligands.
    Type: Application
    Filed: July 9, 2009
    Publication date: January 21, 2010
    Inventors: Paul D. Acton, Dennis J. Hlasta, Jay M. Matthews, James J. McNally
  • TRICYCLIC DELTA-OPIOID MODULATORS
    Publication number: 20090298867
    Abstract: The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic ?-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
    Type: Application
    Filed: August 6, 2009
    Publication date: December 3, 2009
    Inventors: John R. Carson, Ellen Codd, Christine M. Razler, Andrea Works, Mark McDonnell, James J. McNally
  • SULFONAMIDES AS TRPM8 MODULATORS
    Publication number: 20090264474
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
    Type: Application
    Filed: July 18, 2008
    Publication date: October 22, 2009
    Inventors: Shawn T. Branum, Raymond W. Colburn, Scott L. Dax, Christopher M. Flores, Michele C. Jetter, Yi Liu, Donald Ludovici, Mark J. Macielag, Jay M. Matthews, James J. McNally, Laura M. Reaney, Ronald K. Russell, Ning Qin, Christopher Teleha, Kenneth M. Wells, Scott C. Youells, Mark A. Youngman
  • Tricyclic-bridged piperidinylidene derivatives as 8-opioid modulators
    Patent number: 7589103
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows: wherein A, Z, Y, R1-R5 are defined herein.
    Type: Grant
    Filed: June 22, 2004
    Date of Patent: September 15, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: John R. Carson, Ellen Codd, Christine M. Razler, Andrea Works, Mark McDonnell, James J. McNally
  • Tricyclic-bridged piperidinyline derivatives as ยง-opioid modulators
    Patent number: 7589104
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows: wherein A, G, Y, R3, R4, and R5 are defined herein.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: September 15, 2009
    Assignee: Janssen Pharmaceutica NV
    Inventors: John R. Carson, Scott L. Dax, Bart DeCorte, Li Liu, Mark McDonnell, James J. McNally
  • Tricyclic Delta-Opioid Modulators
    Publication number: 20090042871
    Abstract: The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic ?-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
    Type: Application
    Filed: October 9, 2008
    Publication date: February 12, 2009
    Inventors: Steven J. Coats, Scott L. Dax, Bart DeCorte, Li Liu, Mark McDonnell, James J. McNally
  • TRICYCLIC DELTA-OPIOID MODULATORS
    Publication number: 20080318937
    Abstract: The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic ?-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
    Type: Application
    Filed: August 22, 2008
    Publication date: December 25, 2008
    Inventors: Steven J. Coats, Scott L. Dax, Bart DeCorte, Li Liu, Mark McDonnell, James J. McNally
  • QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR
    Publication number: 20080300236
    Abstract: This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to quinoline-derived amides that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
    Type: Application
    Filed: July 16, 2008
    Publication date: December 4, 2008
    Inventors: Ellen Codd, Scott L. Dax, Michele Jetter, Mark McDonnell, James J. McNally, Mark Youngman
  • Tricyclic ?- opioid modulators
    Patent number: 7439239
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows: wherein A, G, Y, R3-R5 are defined herein.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: October 21, 2008
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Steve Coats, Scott L. Dax, Bart DeCorte, Li Liu, Mark McDonnell, James J. McNally
  • Piperdinyl-phenoxazine and phenothiazine derivatives as ?-opioid modulators
    Patent number: 7432257
    Abstract: The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic ?-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: October 7, 2008
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Steve J. Coats, Scott L. Dax, Bart DeCorte, Li Liu, Mark McDonnell, James J. McNally
  • Naphthol, quinoline and isoquinoline-derived urea modulators of vanilloid VR1 receptor
    Patent number: 7183411
    Abstract: This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to naphthol, quinoline and isoquinoline-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: February 27, 2007
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ellen Codd, Scott L. Dax, Michele Jetter, Mark McDonnell, James J. McNally, Mark Youngman
  • Aminotetralin-derived urea modulators of vanilloid VR1 receptor
    Patent number: 6984647
    Abstract: This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to ?-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
    Type: Grant
    Filed: May 15, 2003
    Date of Patent: January 10, 2006
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Scott L. Dax, Michele Jetter, Mark McDonnell, James J. McNally, Mark Youngman