Patents by Inventor James J. Pilla

James J. Pilla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210093763
    Abstract: A method and device are provided for non-blood contact mechanically assisting an injured (e.g., infarcted) ventricle by coupling an inflatable bladder or other volume adjustable device to the injured ventricle and selectively inflating the bladder or increasing the size of the volume in systole to apply force against the injured ventricle and deflating the bladder or reducing the size of the volume in diastole to remove force against the injured ventricle. When no mechanical assistance is being provided to the injured ventricle, the inflatable bladder or volume adjustable device is preferably maintained at a predetermined pressure so as to selectively stiffen the injured tissue and alter ventricular geometry a desired amount.
    Type: Application
    Filed: October 14, 2020
    Publication date: April 1, 2021
    Inventors: James J Pilla, Robert C Gorman, Joseph H Gorman, III
  • Publication number: 20200383632
    Abstract: Provided are devices and methods that deform tissue synchronous with an MR imaging cycle, as well as devices and methods for determination of dynamic determination of one or more mechanical properties of the tissue, including properties of muscle tissue. Such determination can be performed with and without imaging of the tissue being evaluated.
    Type: Application
    Filed: May 29, 2020
    Publication date: December 10, 2020
    Inventors: Anil Chauhan, Lawrence Dougherty, James J Pilla
  • Patent number: 10828409
    Abstract: A method and device are provided for non-blood contact mechanically assisting an injured (e.g., infarcted) ventricle by coupling an inflatable bladder or other volume adjustable device to the injured ventricle and selectively inflating the bladder or increasing the size of the volume in systole to apply force against the injured ventricle and deflating the bladder or reducing the size of the volume in diastole to remove force against the injured ventricle. When no mechanical assistance is being provided to the injured ventricle, the inflatable bladder or volume adjustable device is preferably maintained at a predetermined pressure so as to selectively stiffen the injured tissue and alter ventricular geometry a desired amount.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: November 10, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James J Pilla, Robert C Gorman, Joseph H Gorman, III
  • Publication number: 20190224395
    Abstract: A method and device are provided for non-blood contact mechanically assisting an injured (e.g., infarcted) ventricle by coupling an inflatable bladder or other volume adjustable device to the injured ventricle and selectively inflating the bladder or increasing the size of the volume in systole to apply force against the injured ventricle and deflating the bladder or reducing the size of the volume in diastole to remove force against the injured ventricle. When no mechanical assistance is being provided to the injured ventricle, the inflatable bladder or volume adjustable device is preferably maintained at a predetermined pressure so as to selectively stiffen the injured tissue and alter ventricular geometry a desired amount.
    Type: Application
    Filed: March 12, 2019
    Publication date: July 25, 2019
    Inventors: James J. Pilla, Robert C. Gorman, Joseph H. Gorman, III
  • Patent number: 9999779
    Abstract: Methods and apparatus are provided for applying low magnetic fields (<400 G) to mammalian cells, tissues and organs for protection from the damaging effects of ionizing radiation and other oxygen dependent injuries that involve the radical pair mechanism. The magnetic fields are generated by fixed magnets or active magnets and used to enhance the survival of healthy cells during radiation treatment for cancer, to protect workers from radiation within nuclear power plants, to protect astronauts from radiation during long space voyages, to increase working time in exposed environments, to provide a safe room in hazardous locations, and to protect normal tissue during radiation treatment and in medical imaging modalities that use ionizing radiation (X-ray, CT, mammography). The method described herein may also be used to mitigate the damaging effects of reperfusion, stroke, oxygen toxicity, inflammation, autoimmune disease, and the like by applying protective magnetic fields.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: June 19, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Lawrence Dougherty, James J. Pilla, Keith A. Cengel, Alireza Kassaee
  • Publication number: 20160263390
    Abstract: Methods and apparatus are provided for applying low magnetic fields (<400 G) to mammalian cells, tissues and organs for protection from the damaging effects of ionizing radiation and other oxygen dependent injuries that involve the radical pair mechanism. The magnetic fields are generated by fixed magnets or active magnets and used to enhance the survival of healthy cells during radiation treatment for cancer, to protect workers from radiation within nuclear power plants, to protect astronauts from radiation during long space voyages, to increase working time in exposed environments, to provide a safe room in hazardous locations, and to protect normal tissue during radiation treatment and in medical imaging modalities that use ionizing radiation (X-ray, CT, mammography). The method described herein may also be used to mitigate the damaging effects of reperfusion, stroke, oxygen toxicity, inflammation, autoimmune disease, and the like by applying protective magnetic fields.
    Type: Application
    Filed: October 29, 2014
    Publication date: September 15, 2016
    Inventors: Lawrence DOUGHERTY, James J. PILLA, Keith A. CENGEL, Alireza KASSAEE
  • Publication number: 20140357938
    Abstract: A method and device are provided for non-blood contact mechanically assisting an injured (e.g., infarcted) ventricle by coupling an inflatable bladder or other volume adjustable device to the injured ventricle and selectively inflating the bladder or increasing the size of the volume in systole to apply force against the injured ventricle and deflating the bladder or reducing the size of the volume in diastole to remove force against the injured ventricle. When no mechanical assistance is being provided to the injured ventricle, the inflatable bladder or volume adjustable device is preferably maintained at a predetermined pressure so as to selectively stiffen the injured tissue and alter ventricular geometry a desired amount.
    Type: Application
    Filed: November 30, 2012
    Publication date: December 4, 2014
    Inventors: James J. Pilla, Robert C. Gorman, Joseph H. Gorman
  • Patent number: 6309359
    Abstract: An occlusive cuff is placed around a limb (e.g. an arm) of a patient. A fluid, such as air, is pumped into the cuff, and the pressure in the cuff is measured. The pressure variation in the cuff with respect to time is caused by the pump and expansion/contraction of the arm caused by blood being pumped therethrough by the patient's heart. This variation in pressure is used to calculate systolic and diastolic pressure, artery lumen area compliance and artery volume compliance, artery lumen area, and the blood flow rate through the patient's arteries (e.g. the brachial artery for the case of the patient's arm, or the femoral artery or the case of the patient's leg).
    Type: Grant
    Filed: December 3, 1998
    Date of Patent: October 30, 2001
    Inventors: Michael D. Whitt, Gary M. Drzewiecki, James J. Pilla