Patents by Inventor James John Crawford

James John Crawford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS
    Publication number: 20230279012
    Abstract: Heteroaryl pyridone and aza-pyridone compounds are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using heteroaryl pyridone and aza-pyridone compounds for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
    Type: Application
    Filed: December 20, 2022
    Publication date: September 7, 2023
    Applicant: Genentech, Inc.
    Inventors: James John CRAWFORD, Daniel Fred ORTWINE, BinQing WEI, Wendy B. YOUNG
  • Therapeutic compounds, compositions and methods of use thereof
    Patent number: 11731943
    Abstract: Compounds of Formula (I): and salts thereof, and methods of use as Janus kinase inhibitors are described herein.
    Type: Grant
    Filed: February 17, 2021
    Date of Patent: August 22, 2023
    Assignee: Genentech, Inc.
    Inventors: James John Crawford, Mark Zak, Terry Kellar, Yun-Xing Cheng, Wei Li, F. Anthony Romero, Paul Gibbons, Guiling Zhao, Gregory Hamilton, Simon Charles Goodacre
  • HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS
    Publication number: 20230242506
    Abstract: The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.
    Type: Application
    Filed: September 2, 2022
    Publication date: August 3, 2023
    Applicant: GENENTECHT, INC.
    Inventors: Jason Robert Zbieg, Elisia Villemure, Joachim Rudolph, Paul Powell Beroza, James John Crawford
  • MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
    Publication number: 20230133667
    Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
    Type: Application
    Filed: October 18, 2022
    Publication date: May 4, 2023
    Inventors: Peter Andrew Smith, Tucker Curran Roberts, Robert I. Higuchi, Prasuna Paraselli, Michael F. T. Koehler, Jacob Bradley Schwarz, James John Crawford, Cuong Q. Ly, Emily J. Hanan, Huiyong Hu, Yongsheng Chen, Zhiyong Yu, Paul Colin Michael Winship, Calum MacCleod, Toby Blench
  • MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
    Publication number: 20230133817
    Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
    Type: Application
    Filed: December 8, 2022
    Publication date: May 4, 2023
    Inventors: Yongsheng Chen, Peter Andrew Smith, Tuker Curran Roberts, Robert I. Higuchi, Prasuna Paraselli, Michael F.T Koehler, Jacob Bradley Schwarz, James John Crawford, Cuong Q. Ly, Emily J. Hanan, Huiyong Hu, Zhiyong Yu
  • THERAPEUTIC COMPOUNDS
    Publication number: 20230002396
    Abstract: The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, and compositions and uses thereof. The compounds are useful as inhibitors of the YAP:TEAD protein:protein interaction. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various YAP:TEAD-mediated disorders, including cancer.
    Type: Application
    Filed: May 26, 2022
    Publication date: January 5, 2023
    Applicant: Genentech, Inc.
    Inventors: James John Crawford, Jason Robert Zbieg
  • THERAPEUTIC COMPOUNDS AND METHODS OF USE
    Publication number: 20220281819
    Abstract: The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.
    Type: Application
    Filed: May 12, 2022
    Publication date: September 8, 2022
    Applicant: Genentech, Inc.
    Inventors: Jason Robert Zbieg, James John Crawford, Christian N. Cunningham
  • THERAPEUTIC COMPOUNDS
    Publication number: 20210238184
    Abstract: The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R3 have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of the YAP:TEAD protein:protein interaction. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various YAP:TEAD-mediated disorders, including cancer.
    Type: Application
    Filed: November 25, 2020
    Publication date: August 5, 2021
    Applicant: Genentech, Inc.
    Inventors: Jason Robert Zbieg, Paul Powell Beroza, James John Crawford
  • Macrocyclic broad spectrum antibiotics
    Patent number: 11072635
    Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: July 27, 2021
    Assignees: RQX Pharmaceuticals, Inc., Genentech, Inc.
    Inventors: Yongsheng Chen, Peter Andrew Smith, Tucker Curran Roberts, Robert I. Higuchi, Prasuna Paraselli, Michael F. T. Koehler, Jacob Bradley Schwarz, James John Crawford, Cuong Q. Ly, Huiyong Hu, Zhiyong Yu
  • MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
    Publication number: 20210198316
    Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
    Type: Application
    Filed: August 13, 2019
    Publication date: July 1, 2021
    Inventors: Peter Andrew SMITH, Tucker Curran ROBERTS, Robert I. HIGUCHI, Prasuna PARASELLI, Michael F. T. KOEHLER, Jacob Bradley SCHWARZ, James John CRAWFORD, Cuong Q. LY, Emily J. HANAN, Huiyong HU, Yongsheng CHEN, Zhiyong YU, Paul Colin Michael WINSHIP, Calum McCleod, Toby Blench
  • CARBOXAMIDE AND SULFONAMIDE DERIVATIVES USEFUL AS TEAD MODULATORS
    Publication number: 20210188775
    Abstract: The invention is concerned with the compounds of formula (I) and formula (II): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of using the compounds of formula (I) and formula (II) as well as pharmaceutical compositions containing such compounds. The compounds are useful in treating diseases and conditions mediated by TEAD, such as cancer.
    Type: Application
    Filed: March 2, 2021
    Publication date: June 24, 2021
    Applicant: Genentech, Inc.
    Inventors: Christian CUNNINGHAM, Paul Powell BEROZA, James John CRAWFORD, Wendy Lee, Olivier RENE, Jason Robert ZBIEG, Jiangpeng LIAO, Tao WANG, Chen YU
  • THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20210179564
    Abstract: Compounds of Formula (I): and salts thereof, and methods of use as Janus kinase inhibitors are described herein.
    Type: Application
    Filed: February 17, 2021
    Publication date: June 17, 2021
    Applicant: Genentech, Inc.
    Inventors: James John Crawford, Mark Zak, Terry Kellar, Yun-Xing Cheng, Wei Li, F. Anthony Romero, Paul Gibbons, Guiling Zhao, Gregory Hamilton, Simon Charles Goodacre
  • HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS
    Publication number: 20210079002
    Abstract: Heteroaryl pyridone and aza-pyridone compounds are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using heteroaryl pyridone and aza-pyridone compounds for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
    Type: Application
    Filed: August 24, 2020
    Publication date: March 18, 2021
    Applicant: Genentech, Inc.
    Inventors: James John CRAWFORD, Daniel Fred ORTWINE, BinQing WEI, Wendy B. YOUNG
  • Piperidine derivatives as inhibitors of ubiquitin specific protease 7
    Patent number: 10766903
    Abstract: The present invention concerns the identification of inhibitors of ubiquitin specific protease 7 (USP7), and methods of use thereof.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: September 8, 2020
    Assignee: ALMAC DISCOVERY LIMITED
    Inventors: Colin O'Dowd, Tim Harrison, Peter Hewitt, Shane Rountree, Miel Hugues, Frank Burkamp, Linda Duncan Jordan, Matthew Helm, Fabio Broccatelli, James John Crawford, Lewis Gazzard, Ingrid Wertz, Wendy Lee
  • MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
    Publication number: 20200239519
    Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
    Type: Application
    Filed: November 21, 2016
    Publication date: July 30, 2020
    Inventors: Yongsheng CHEN, Peter Andrew SMITH, Tucker Curran ROBERTS, Robert I. HIGUCHI, Prasuna PARASELLI, Michael F. T. KOEHLER, Jacob Bradley SCHWARZ, James John CRAWFORD, Cuong Q. LY, Huiyong HU, Zhiyong YU
  • 2-azabicyclo[3.1.0]hexan-3-one derivatives and methods of use
    Patent number: 10654824
    Abstract: The invention relates to compounds of formula (I): wherein A1, A2, A3, A4, A5, A6, A7, A8, R4a, R4b and R5 are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: May 19, 2020
    Assignee: Genentech, Inc.
    Inventors: James John Crawford, Aleksandr Kolesnikov, Jianwen A. Feng
  • HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS
    Publication number: 20200062769
    Abstract: Heteroaryl pyridone and aza-pyridone compounds are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using heteroaryl pyridone and aza-pyridone compounds for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
    Type: Application
    Filed: October 31, 2019
    Publication date: February 27, 2020
    Applicant: Genentech, Inc.
    Inventors: James John CRAWFORD, Daniel Fred ORTWINE, BinQing WEI, Wendy B. YOUNG
  • 2-azabicyclo[3.1.0]hexan-3-one derivatives and methods of use
    Patent number: 10550117
    Abstract: The invention relates to compounds of formula (I): wherein Q, A1, A2, A3, A5, A6, A7, A8, R4a, R4b and R5 are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: February 4, 2020
    Assignee: Genentech, Inc.
    Inventors: James John Crawford, Aleksandr Kolesnikov, Jianwen A. Feng
  • MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
    Publication number: 20200024309
    Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
    Type: Application
    Filed: August 13, 2019
    Publication date: January 23, 2020
    Inventors: Peter Andrew SMITH, Tucker Curran ROBERTS, Robert I. HIGUCHI, Prasuna PARASELLI, Michael F. T. KOEHLER, Jacob Bradley SCHWARZ, James John CRAWFORD, Cuong Q. LY, Emily J. HANAN, Huiyong HU, Yongsheng CHEN, Zhiyong YU, Paul Colin Michael WINSHIP, Calum McCleod, Toby Blench
  • Heteroaryl pyridone and aza-pyridone compounds
    Patent number: RE48239
    Abstract: Heteroaryl pyridone and aza-pyridone compounds of Formula I are provided, where one or two of X1, X2, and X3 are N, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: October 6, 2020
    Assignee: Genetech, Inc.
    Inventors: James John Crawford, Daniel Fred Ortwine, BinQing Wei, Wendy B. Young