Abstract: Systems and methods include receiving Operations, Administration, Maintenance, and Provisioning (OAM&P) data from an optical network; providing a Graphical User Interface (GUI) based on the OAM&P data with the GUI including a topology view; and providing a visualization that includes one of a power readings graph, a spectral analysis graph, and a spectral allocation graph, in the GUI, and the visualization is positioned logically next to the topology view.

Abstract: Systems and methods include receiving Operations, Administration, Maintenance, and Provisioning (OAM&P) data from an optical network; providing a Graphical User Interface (GUI) based on the OAM&P data with the GUI including a topology view; and providing a visualization that includes one of a power readings graph, a spectral analysis graph, and a spectral allocation graph, in the GUI, and the visualization is positioned logically next to the topology view.

Abstract: A network management system includes a network interface communicatively coupled to one or more network elements in a network for exchanging Operations, Administration, Maintenance, and Provisioning (OAM&P) data; a processor communicatively coupled to the network interface; and memory storing instructions that, when executed, cause the processor to obtain the OAM&P data from the network, provide a Graphical User Interface (GUI) based on the network from the OAM&P data, wherein the GUI includes a network map which provides a topological view and a subway view which provides a detailed device-level view which is more granular than the network map and illustrates individual components at each site, receive a selection from a user of a service in the network, and update the GUI to highlight the service in the network map and illustrate the associated sites in the subway view.

Abstract: A network management system includes a network interface communicatively coupled to one or more network elements in a network for exchanging Operations, Administration, Maintenance, and Provisioning (OAM&P) data; a processor communicatively coupled to the network interface; and memory storing instructions that, when executed, cause the processor to obtain the OAM&P data from the network, provide a Graphical User Interface (GUI) based on the network from the OAM&P data, wherein the GUI includes a network map which provides a topological view and a subway view which provides a detailed device-level view which is more granular than the network map and illustrates individual components at each site, receive a selection from a user of a service in the network, and update the GUI to highlight the service in the network map and illustrate the associated sites in the subway view.

Abstract: A method of managing an optical communication network having a plurality of nodes, the plurality of nodes including at least one regeneration site. A respective Path Computation Element (PCE) function is instantiated and associated with each regeneration site in the network. Each PCE function maintains a reach table containing information of viable optical paths extending from transceivers of its regeneration site. The PCE function implements a Recursive Path Computation algorithm to compute end-to-end routes through a physical layer of the network.

Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.

Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

Abstract: The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3?-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (S)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients.

Abstract: A method of managing an optical communication network having a plurality of nodes, the plurality of nodes including at least one regeneration site. A respective Path Computation Element (PCE) function is instantiated and associated with each regeneration site in the network. Each PCE function maintains a reach table containing information of viable optical paths extending from transceivers of its regeneration site. The PCE function implements a Recursive Path Computation algorithm to compute end-to-end routes through a physical layer of the network.

Abstract: The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.

Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

Abstract: The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3?-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (S)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients.

Abstract: The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.

Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.

Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

Abstract: The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.

Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.

Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.