Abstract: The invention relates generally to activatable antibodies that include a masking moiety (MM), a cleavable moiety (CM), and an antibody (AB) that specifically binds to interleukin-6 receptor (IL-6R), and to methods of making and using these anti-IL-6R activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: The disclosure relates to a tissue culture device and components of a system used to grow, maintain and measure recording from cells. In some embodiments, the tissue culture device is an insert with a surface onto which cells may be plated and grown. Electrodes on or near the surface of the cells can be used to measure electrophysiological data when current is applied to the system.

Abstract: A noise or vibration detection system includes a clamping device with an audio transducer and a wireless transmitter. The transmitter transmits the audio signal, or a modified version of the audio signal, from the transducer. A mobile device located remote from the transmitter receives the transmitted audio signal for processing. The mobile device includes a receiver configured to receive the audio signal, a display configured as a user interface and to display information to a user, a memory configured to store non-transient machine executable code, and a processor configured to execute the machine executable code stored on the memory. The machine executable code is configured to process the received signal to form an audio signal which is presented to a speaker of the mobile device or a headphone port of the mobile device and also display the audio signal in graphical form on the display.

Abstract: An appliance hub for use in an upper portion of an enclosure can include a substrate configured to be positioned in an upper portion of an enclosure. The appliance hub can include a climate control apparatus mounted on the substrate and the climate control apparatus can be configured to regulate a temperature within the enclosure. The appliance hub can include one or more lighting elements configured to provide light within the enclosure, a plurality of fluid lines connected to the substrate and configured to provide fluid service and return to the climate control apparatus, and/or a plurality of electrical connections connected to the substrate and configured to provide electrical power and/or data to at least one of the climate control apparatus and the one or more lighting elements.

Abstract: A poolside burner having a central gas feed and a burner ring having longitudinally-oriented slit-like flame orifices. The burner ring is securely attached to a burner plate having a centralized hole through which a feeder extends and mates with a central distribution tube connected to the burner ring.

Abstract: An outdoor decorative burner having a direct gas feed and a linear burner having a plurality of longitudinally-oriented slit-like flame orifices. The linear burner is securely attached to a plate by at least two wrap brackets. A direct spark igniter and a flame sensor are included and surrounded by protective cages.

Abstract: A writing instrument with a cap that lockingly engages a body portion via a locking assembly is presented herein. The locking assembly includes a pair of locking tabs on the cap that correspondingly fit within locking channels on the body of the writing instrument. With the tabs positioned within the locking channels, the cap is twisted or rotated such that the locking tabs slide past a node within the channels and restricts removal of the cap from the body portion.

Abstract: The invention relates generally to antibodies that bind programmed death ligand 1 (PDL1), activatable antibodies that specifically bind to PDL1 and methods of making and using these anti-PDL1 antibodies and anti-PDL1 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one matrix metalloprotease (MMP), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one MMP protease, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one MMP protease in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: The invention relates generally to polypeptides that include at least a first cleavable moiety (CM1) that is a substrate for at least one matrix metalloprotease (MMP) and at least a second cleavable moiety (CM2) that is a substrate for at least one serine protease (SP), to activatable antibodies and other larger molecules that include these polypeptides that include at least a CM1 that is a substrate for at least one MMP protease and at least a CM2 that is a substrate for at least one SP protease, and to methods of making and using these polypeptides that include at least a CM1 that is a substrate for at least one MMP protease and at least a CM2 that is a substrate for at least one SP protease in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: The invention relates generally to antibodies that bind programmed death ligand 1 (PDL1), activatable antibodies that specifically bind to PDL1 and methods of making and using these anti-PDL1 antibodies and anti-PDL1 activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: A modified eddy current (MEC) probe includes a probe body having a bore formed therein. A printed circuit board (PCB) assembly includes a circuit board defining a plane, has a plurality of electronic components mounted thereon, and is configured for mounting within the bore of the probe body. A coil board assembly is electrically connected to the PCB assembly, defines a plane, and includes a first coil board layer, a second coil board layer bonded to the first coil board layer, a transmitter coil formed on an outside surface of the first coil board layer, a Faraday shield formed on an outside surface of the second coil board layer, and a sensor coil formed on one of an inside surface of the first coil board layer and the second coil board layer, such that the sensor coil is positioned between the first coil board layer and the second coil board layer. The plane of the coil board assembly is arranged orthogonally to the plane of the circuit board.

Abstract: Systems for cleaning a storage tank and fluid hydrocarbons stored within the storage tank comprise: a vehicle for transporting the system between sites having said storage tanks; a fluid cleaning circuit mounted with respect to said vehicle for extracting fluid hydrocarbons from the storage tank for cleaning; a settlement tank mounted with respect to said vehicle to be in fluid communication with the fluid cleaning circuit to receive contaminated fluid hydrocarbons for separation by gravity; wherein the fluid cleaning circuit is controllable to clean the fluid hydrocarbons and the storage tank and to dispose of any waste material extracted from the fluid hydrocarbons during the cleaning process and following disposal of the waste material the fluid cleaning circuit is configured to convert the settlement tank into a non-volatile environment prior to the vehicle leaving the site.

Abstract: A child-resistant writing instrument with a cap that lockingly engages a body portion via a locking assembly is presented herein. The locking assembly includes a pair of locking protrusions or pins on the cap that correspondingly fit within locking channels on the body of the writing instrument. A biasing mechanism, such as a spring, is used to bias the cap when locked to the body portion. Specifically, when the locking pins are positioned to enter the locking channel, the cap is pushed against the biasing force of the spring until the locking pins or protrusions enter a lateral or inner groove of the locking channel. The cap is then twisted or rotated such that the locking pins slide within the lateral groove toward a locking notch. The biasing force of the spring will then bias the pins into the locking notch, thereby locking the cap to the body.

Abstract: The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator (uPA), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and u-plasminogen activator in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: A spray head suitable for mounting on a flexible hose, wherein the spray head comprises a rotary switching mechanism for permitting selection of either a stream flow (i.e. laminated flow) or a spray flow, e.g. by directing flow received from the hose through different outlet nozzles. By providing a compact rotary switching action, the spray head may overcome problems caused by wear or scale build up that are seen in push button or linear switching mechanisms.

Abstract: A method of making a lithium alkylsiliconate composition comprising adding an alkylalkoxysilane to a first mixture comprising lithium hydroxide and water to form a second mixture comprising a lithium alkylsiliconate and an alcohol, wherein i) the mole ratio of lithium hydroxide to alkylalkoxysilane is from 0.9 to less than 1.1 and the water is from 89 to 93 mol %, or ii) the mole ratio of lithium hydroxide to alkylalkoxysilane is from 1.1 to 1.4 and the water is from greater than 93 to 99 mole %.

Abstract: A method includes receiving, at a processor, event stream data, the event stream data including a plurality of events associated with changes to an instance of a subject. The method further includes receiving, at the processor of the computing device, input indicating correction data. The method further includes outputting, from the processor of the computing device, modified event stream data to a storage device. The modified event stream data is generated based on the correction data by modifying an event of the event stream data, adding a first event to the event stream data, deleting a second event from the event stream data, or a combination thereof.

Abstract: The present disclosure provides methods for forming sol-gels, sol-gel films and substrates, such as vehicle components, having a sol-gel film disposed thereon. At least one method of forming a sol-gel includes mixing a metal alkoxide, an acid stabilizer, and an organic solvent to form a first mixture having about 10 wt % or less water content based on the total weight of the first mixture. The method includes mixing an organosilane with the first mixture to form a second mixture having about 10 wt % or less water content based on the total weight of the second mixture.