Abstract: Apparatuses, systems, and methods for preclinical ultrasound imaging of subjects are provided. In one aspect, the apparatus can include a platform on which a subject is positionable and at least one motion stage for controlling a spatial position of at least one ultrasound transducer relative to the platform in order to acquire ultrasound image data of the subject. Methods for preclinical ultrasound raster scanning of at least one organ or tissue in a subject are also provided, where the at least one organ or tissue is a heart.

Abstract: Provided are systems for analyzing cellular distribution in an engineered tissue sample, which optionally is a bioprinted organ or tissue sample. In some embodiments, the systems include an ultrasound imaging system and a processing unit configured with software that permits analysis of images acquired from the engineered tissue sample in order to output desired characteristics thereof. In some embodiments, the systems also include a bioreactor for engineering a tissue sample and a pump configured to regulate flow of fluids and reagents into and out of the bioreactor, wherein at least one surface of the bioreactor includes a window that is acoustically transparent to ultrasound waves. Also provided are systems for analyzing cell distribution in an engineered tissue sample and methods for analyzing distribution of cells in an engineered tissue sample present within a bioreactor.

Abstract: Apparatuses, systems, and methods for preclinical ultrasound imaging of subjects are provided. In one aspect, the apparatus can include a platform on which a subject is positionable and at least one motion stage for controlling a spatial position of at least one ultrasound transducer relative to the platform in order to acquire ultrasound image data of the subject. Methods for preclinical ultrasound raster scanning of at least one organ or tissue in a subject are also provided, where the at least one organ or tissue is a heart.