Patents by Inventor James P. Fulginiti

James P. Fulginiti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stable pura vectors and uses therefor
    Patent number: 5961983
    Abstract: This invention pertains to a complementation system for the selection and maintenance of expressed genes in bacterial hosts. The invention provides stable vectors which can be selected and maintained by complementation of chromosomal deletion mutations of purA (adenylosuccinate synthetase), obviating the use of antibiotic resistance genes. This system is useful in production organisms during fermentation and in live vaccine bacteria, such as attenuated Salmonella typhi. This system allows for selection of chromosomal integrants and for selection and stable plasmid maintenance in the vaccinated host without application of external selection pressure.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: October 5, 1999
    Assignee: Praxis Biologics, Inc.
    Inventors: Robert N. Brey, James P. Fulginiti, Algis Anilionis
  • Stable purA vectors and uses therefor
    Patent number: 5919663
    Abstract: This invention pertains to a complementation system for the selection and maintenance of expressed genes in bacterial hosts. The invention provides stable vectors which can be selected and maintained by complementation of chromosomal deletion mutations of purA (adenylosuccinate synthetase), obviating the use of antibiotic resistance genes. This system is useful in production organisms during fermentation and in live vaccine bacteria, such as attenuated Salmonella typhi. This system allows for selection of chromosomal integrants and for selection and stable plasmid maintenance in the vaccinated host without application of external selection pressure.
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: July 6, 1999
    Assignee: American Cyanamid Company
    Inventors: Robert N. Brey, James P. Fulginiti, Algis Anilionis